Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
6 Cards in this Set
- Front
- Back
|
Dzs with Parkinsonism and nigrostriatal involvement
|
Parkinson Dz
Multiple system atrophy Postencephalitic Parkinsonism (1918 flu) progressive supranuclear palsy and corticobasal degeneration |
|
|
PD path gross
|
pallor of substantia nigra and locus ceruleus
|
|
|
PD path micro
|
loss of pigmented (catecholaminergic) neurons in SN and LC (and basal nucleus of Meynert); gliosis; Lewy bodies
|
|
|
Lewy bodies micro
|
single or multiple, cytoplasmic, eosinophilic, round inclusions with dense core surrounded by a pale halo. α-synuclein filament positive.
|
|
|
Genes associated with PD
|
α-synuclein (4q21) in autosomal dominant PD
LRRK2 in autosomal dominant PD parkin (relat to ubiquitin) in autosomal recessive juvenile PD (no Lewy bodies) DJ-1 and PINK1 (mitochondrial fxn) in autosomal recessive PD |
|
|
Multiple system atrophy characteristic pathology
|
alpha synuclein positive inclusions (20-40nm) in oligodendrocytes (possibly from secondary uptake); cerebellum , pons, inferior olive, subst. nigra; no genetics known
|
