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18 Cards in this Set
- Front
- Back
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which of the paramyxoviridae Family of viruses is not dz of children
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NIPAH - newly found
compared to measles, mumps in same family |
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What is transmission mechanism for Henipavirus
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body fluids?
airborne? |
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What is newly formed genus in family Para;myxoviridae
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genome significantly larger than other paramyxos - Genus Henipavirus
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what are two human pathogens of Genus hemipavirus
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Hendra and Nipah in 1994 and 99
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What are Henipavirus associated with cliically
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encephalitis and respiratory disease (first seen in horses)
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Hendra Virus was seen where and in what human cases first
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Queensland, Australia in horse handlers. 2 flu-like, 1 fatal
1 encephalitis, fatal no human-human transmission |
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what was first name of Hendra Virus
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equine morbilivirus
Serology of healthy humans and horses, negative. |
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How named Hendra virus
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town where 1st case recognized
antibodies found in 'flying foxes" - bats |
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describe NIPAH outbreak epi
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1998-1999: febrile encephalitis in Malaysian MOF (CFR~40%)
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NIPAH outbreak was associated with what animal
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close contact with pigs
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what was Nipah first thought to be
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JE
found syncytia in cell culture negative for JE sera |
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what tests proved Nipah
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EM suggest paramyxo
cells IFA positive with Hendra aby similar but not identical |
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clinical signs of Nipah
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3-14 d w/fever and HA
drowsiness, confusion, loss of balance symptoms can progress to coma w/in 24-48 h some have respiratory illness |
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TX for Nipah
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maybe Ribavirin
support, antiepileptic meds, rehabilitation |
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What is transmission of Nipah Virus to humans
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infected pigs
No human-human transmission not from cooked portk |
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what is primary reservoir for Nipah
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Pteropus bats
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WHAT OTHER SPECIES INFECTED IN FARMS WHERE PIGS PRESENT
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dogs, cats, horses
NOT INFECTED: chickens, rodents, insectivorous bats |
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how stop transmission of Nipah
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cull positive farms , serologic testing of swine, regular reporting of sick pigs
education embargo on transport of pigs from affected area |
