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56 Cards in this Set
- Front
- Back
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Paramyxoviridae order
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Mononegavirales
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Paramyxoviridae characteristics
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helical, enveloped, spherical, - ss RNA,
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Paramyxoviridae genus
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Morbillivirus
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Paramyxoviridae Morbillivirus Species
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Canine distember virus
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Paramyxoviridae Rubulavirus species
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Canine parainfluenza virus 2
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Paramyxoviridae Respirovirus species
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Bovine parainfluenza virus 1
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Paramyxoviridae Pneumovirus species
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Bovine respiratory syncytial virus
Human respiratory syncytial virus |
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Paramyxoviridae surface proteins
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H - hemagglutinin
HN - hemagglutinin + neuraminidase G - glycoprotein F - Fusion protein M - matrix L - large protein N - nucleocapsid |
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Difference between Influenza and Paramyxoviridae fusion proteins
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Influenza's fusion protein is part of HA
Para - sep protein. |
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Mechanism of H protein to cell receptor
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Binding of H protein to cellular receptor causes conformational activation of F protein.
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Fusion of cell membrane and viral membrane allows for
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viral penetration (neutral pH)
cell - cell fusion (syncytia formation) |
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A unique visiable characteristic of paramyxovirus infection
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syncitial cells
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Paramyxovirus transcription produces______ because polymerase ________.
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several short viral proteins
falls on and off the genome |
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Paramyxovirus replicates in the
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cytoplasm
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Canine distemper virus causes
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acute highly contagious disease
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Canine distemper virus (morbillivirus) infects what animals
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dogs, ferrets, skunk, raccoon,
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Canine Distemper virus exhibits tropism for
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epithelium and lymphoid tissue
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Canine Distemper virus can ultimately cause
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subacute encephalitis and death
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diphasic fever, ocular and nasal discharge, leukopenia, vomiting, diarrhea, pneumonia, CNS signs, 2nd infections
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Canine distemper virus
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Canine Distemper virus CNS disease
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encephalititis with demyelination, paresis, paralysis, convulsions, twitching, chewing-gum fits, paddling
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Canine Distemper virus sometimes comes back as
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old-dog encephalitis years after initial recovery
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Even if Canine Distemper virus infection subsides, it my cause permanent
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loss of myelin
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Canine distemper virus clinical signs
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footpad hyperkeratosis
nasal hyperkeratosis vesicular and pustular dermatitis delayed response due to viral persistence in skin hyperkeratosis |
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Canine distemper virus in utero causes
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enamel hypoplasia and loss on the teeth
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Canine distemper virus diagnosis
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history - unvaccinated dog with fever, respiratory disease CNS signs
conjunctival scrapings, buffy coat |
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Canine distemper virus histopathology
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interstitial pneumonia
intracytoplasmic and or intranuclear inclusion syncitia |
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Long term recovery of CDV infected dogs
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dogs with GI or respiratory signs - fair prognosis - may have permanent damage to mucociliary apparatus
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A dog that recovers from CDV may develop _____ 3 monhts after infection
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CNS signs
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Dogs infected with CDV and have neurological signs have a _____ prognosis
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poor
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CDV virus shedding _______
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may persist up to 3 months in recovered dogs. separate from other dogs for minimum of 4 weeks, puppies, unvaccinated and immunosuppressed dogs for 3 months
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Newcastle disease virus genus
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Avulavirus
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Newcastle disease causes
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respiratory and GI disease
CNS involvement (chickens, turkey, wild birds) |
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Three types of Newcastle disease
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velogenic - virulent
mesogenic - moderately virulent lentogenic - low virulence |
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Acute lethal disease with GI hemorrhage respiratory signs
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Viscerotropic velogenic
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CNS and respiratory disease
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Neuroltropic velogenic
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Acute respiratory disease, CNS involvement
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mesogenic
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mild or inapparent respiratory disease
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lentogenic
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asymptomatic-enteric
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subclinical GI infections with lentogenic virus
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virulence of Newcastle disease virus dependent on
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activation of fusion protein by cellular proteases
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Clinical signs of Newcastle disease virus
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respiratory and/or CNS signs
drop in egg production diarrhea hemorrhage, periorbital and neck edema, conjunctivitis |
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Newcastle disease virus is a zoonotic risk for
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poultry workers (conjunctivitis and flu-like symptoms)
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Canine parainfluenza virus 2 genus
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Rubulavirus
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Canine parainfluenza virus 2 is a contributor to
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infectious tracheobronchitis along with CAV-2, B bronchiseptica
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CPV-2 clinical signs
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subclinical or mild infection, self limiting, fever, nasal discharge, harsh nonproductive cough, ontsilitis, pharyngitis, trachobronchitis
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CPV-2 vaccination
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combination vaccine
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Bovine parainfluenza virus 3 genus
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Respirovirus
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Bovine parainfluenza virus 3 is a contributor to
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contributor to bovine respiratory disease complex (shipping fever) with M haemolytica, P.multocida, H somni + IBR, BRSV, BVDV, BCoV, BPIV-3
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BPV-3 pathogenesis
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viral replication in alveolar Mo, respiratory epithelium
decreased IM damage to mucocilliary apparatus |
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BPV-3 vaccination
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combination vaccines available
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Bovine respiratory syncytial virus genus
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Pneumovirus
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Bovine respiratory syncytial virus causes
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respiratory disease of cattle (sheep/goats);
subclinical, severe interstitial pneumonia, contributes to BRDC |
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BRSV clinical signs
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fever, dyspnea, cough, open=mouth breathing, recovery, 1 - 2 weeks, severe disease, death, related to high percentage of calf pneumonias
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BRSV may cause in calves<6 months
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severe disease
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BRSV pathological changes
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pneumonia, bronchiolitis, emphysema,
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BRSV characteristic features
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cyncytial cells, cytoplasmic inclusions
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BRSV treatment/control
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antibiotics to control bacterial infections
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