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24 Cards in this Set
- Front
- Back
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Which pain, cancer or therapy,m is numb/fatigue?
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therapy
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which pain, cncer or therapy is chronic pain?
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cancer
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tumor derived pain - release of ____factors that act on_____.
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pro-inflammatory
periph nociceptors |
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Factors released by tumors
PG's Endothelins kinin Il1b/il6 GFs which is vasoactive? |
endothelin
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which endothelins are popular for tumors
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1,2,3
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B1/B2 (jkinin receptors) which is always on? which is upregulated if injured?
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b2 always on
b1 - low upregulated |
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most common neurotoxicity side effect of chemo?
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PPN
painful peripheral neuopathy |
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IL1B or IL6
initiates neuro pain |
IL6
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IL1b or IL6
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mehanical hhyperlagesi
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PPN is often assoc with a higher than normal chemo dose
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F - with reduction or elinmination of tx
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what chemo drug come sfrom YEW?
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taxane
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Taxanes work how?
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inihbit microtubule formation
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what druginhibits microtub formation?
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taxane
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what drug causes "stocking glove" effect
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taxane
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what is the phenom where the longest axons are killed/injured 1st such as hand and feet, what causes it?
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stocking glove
by taxaneds |
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upreg of ATF3, a stres marker may be arecent sign of
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paclitaxel
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what drug causes accumulation of neurofilaments?
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paclitaxel
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paclitaxel causes what?
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accumulation of neurofilaments
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what drug from madagascard periwinkle?
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vinca alkaloids
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vinca alkaloids come from
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madagascar periwinkle
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what chemo drugs inhibit dna synthesis, via cross linking of dna?
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platinum drugs
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3 examples of platinum drugs
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carboplatin
cisplatin oxaplatin |
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carbo cis - for h/n/ov
oxa - colorectal what are these? |
platinum drugs
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advantage to vinca alkaloids to taxanes?
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don't need to suspend in creamofor
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