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26 Cards in this Set
- Front
- Back
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NSAIDS AND NARCOTICS
Nonsteroidal Anti-Inflammatory Drugs Mechanism of action: |
work by inhibiton of prostanoid synthesis. Prostanoids, such as prostaglandins, prostacyclins, and thromboxans, are products of the metabolism of a fatty acid found in cell membranes called arachidonic acid. NSAIDS inhibit the first step in this metabolism, by inhibiting an enzyme called cyclooxygenase (COX).
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NSAIDS AND NARCOTICS
Nonsteroidal Anti-Inflammatory Drugs Cox 1: List all drugs |
A.Aspirin (acetyslicylic acid)
B. Idomethacin (Indocin) C. Ketorolac (Toradol, Aculan OPHT |
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NSAIDS AND NARCOTICS
Nonsteroidal Anti-Inflammatory Drugs: Cox 1 Adverse effects: |
ulcers in high doses…prolonged bleeding time
Metabolized: liver eliminated by kidney. Metabolized by glucuronidation Uses: benefisical in low doses as an antithrombotic agent, decreasing the formation of small clots. Potent anti inflammitiory with immediate effects |
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NSAIDS AND NARCOTICS
Nonsteroidal Anti-Inflammatory Drugs: Ketorolac (Toradol, Aculan OPHT) Contraindicated |
in patients with peptic ulcers.epidural anesthia and nursing mothers
Adverse effects: renal toxicity, anaphylaxis (life threating allergic reaction) and increased risk of bleeding. |
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NSAIDS AND NARCOTICS
Nonsteroidal Anti-Inflammatory Drugs: Both Cox 1 and 2 List all drugs |
A. ibuprofen ( IBU, Motrin, Advil, Provil)
B. Ketoprofen (Actron, Oruvail, orvdis) C. Flurbiprofin (ansaid, Ocufen (ophthalmic) D. Sulindac (Clinoril) E. Nabumetone (Relafen) F. Naproxen ( Naprosyn, EC-Naprosyn, Naprelan) G. Naproxen Sodium ( Anaprox, Naprelan, Aleve (otc) |
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NSAIDS AND NARCOTICS
Nonsteroidal Pain Relievers List Drug: |
Acetaminophen (Tylenol)
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NSAIDS AND NARCOTICS
Nonsteroidal Pain Relievers Acetaminophen (Tylenol) Metabolized: |
eliminated by hepatic not suitable for liver -compromised patients; causes extreme liver toxicity with large or frequent doses
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NSAIDS AND NARCOTICS
Nonsteroidal Pain Relievers Acetaminophen (Tylenol) Mechanism of action: |
direct suppression of cortical and thalamic centers. Acetaminophen is not a cyclooxygenase inhibitor, and it is not an anti- inflammatory agent.
Physiological actions: Analgesia, anesthesia, euphoria, antitussive effects, nausea and vomiting (emesis); miosis, antidiarrheal effects (slow peristalisis in the bowel); respiratory depression |
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NSAIDS AND NARCOTICS
Narcotic Analgesics Mechanism of action: |
act at the level of the spinal cord to relieve pain. These agents also act at sites in the central nervous system to reduce the perception of pain.
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NSAIDS AND NARCOTICS
Narcotic Analgesics Adverse effects: |
hypertension; decrease in bowel movement(constipation); pinpoint pupils, or miosis; respitory depression
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NSAIDS AND NARCOTICS
Narcotic Analgesics Interactions |
antipsychotics -synergism- severe hypotension and sedation are produced; sedative hypnotics-synergism(extreme sedation); elevated body temp produced by opiates may combine with the effects of MAO Inhibitors to produce a hyperpyrexic coma.
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NSAIDS AND NARCOTICS
Narcotic Analgesics List all drugs: |
A. Morphine Sulfate (Morph Sul, MSIR, RMS, Roxanol)
B. Meperidine hydrochloride ( Demerol) C. Hydromorphone hydrochloride (Dilaudid) D. Fentanyl aka fentanyl base (Actiq) E. Fentanyl citrate (Duragesic transdermal patch) F. Methadone (Dolophine) G. Codeine and acetaminophen ( Tylenol #1, #2, #3, or #4) H. Hydrocodone and Acetaminophen ( Anexia, Lorcet, Vicodin) I. Oxycodone (Percocet, Percodan) |
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NSAIDS AND NARCOTICS
Narcotic Analgesics Codeine and acetaminophen ( Tylenol #1, #2, #3, or #4) Class: |
CIII
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NSAIDS AND NARCOTICS
Narcotic Analgesics Hydrocodone and Acetaminophen ( Anexia, Lorcet, Vicodin) Class: |
CIII
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NSAIDS AND NARCOTICS
Narcotic Analgesics Oxycodone (Percocet, Percodan) (combined with aspirin) Class: |
CII
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NSAIDS AND NARCOTICS
Narcotic Analgesics Opiates with Low abuse potential List all drugs: |
A. Propoxyphene hydrochloride with aspirin ( Darvon, Doloxene, Progesic)
B. Propoxyphene napsylate (Darvon-N) |
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NSAIDS AND NARCOTICS
Narcotic Analgesics Opiates with Low abuse potential Propoxyphene napsylate (Darvon-N) Classification |
c-II execpt when in combo with acetaminophen (C-IV) or atropine (C-V)
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NSAIDS AND NARCOTICS
Narcotic Analgesics Partial Agonists and Antagonists List all drugs: |
A. Buprenorphine (stadol, stadol NS)
B. Pentazocine (Talwin) |
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NSAIDS AND NARCOTICS
Narcotic Analgesics Partial Agonists and Antagonists Pentazocine (Talwin) Class: |
C-IV
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NSAIDS AND NARCOTICS
Narcotic Analgesics Partial Agonists and Antagonists Pentazocine (Talwin) Adverse effects: |
high degree of psychiatric effects produced by pentazocine, including anxiety, nightmares, and hallucinations
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NSAIDS AND NARCOTICS
Narcotic Analgesics Opiate Antagonists Uses: |
opiate addiction or intoxication, reversal or the respiratory depression caused by opiates.
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NSAIDS AND NARCOTICS
Narcotic Analgesics Opiate Antagonists List drugs: |
A. Naloxone (Narcan)
B. Nalmefene (Revex) C. Naltrexone (ReVia |
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NSAIDS AND NARCOTICS
Narcotic Analgesics Opiate Antagonists Naloxone (Narcan) Mech of action: |
has been used to reverse the effects of ethanol and benzodiazepines, to reverse hypotension associated with spinal injury, to improve neurologic recovery afeter ischemic stroke, and to treat hypercapnic COPD
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NSAIDS AND NARCOTICS
Narcotic Analgesics Opiate Antagonists Naloxone (Narcan) Duration: |
Naloxone is very short-acting, with reversal of effects seen in a matter of minutes.
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NSAIDS AND NARCOTICS
Narcotic Analgesics Opiate Antagonists Naloxone (Narcan) Uses: |
besides treatment of opiate overdose, it has been used to reverse the effects of ethanol and benzodiazepines, to reverse hypotension associated with spinal injury, to improve neurologic recovery after ischemic stroke, and to treat hypercapnic COPD.
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NSAIDS AND NARCOTICS
Narcotic Analgesics Opiate Antagonists Naltrexone (ReVia) Half life: |
3 days
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