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9 Cards in this Set

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  • Back
Clinical chemistry findings suggestive of Paget's disease? (2)
High ALP

High PTH
Osteomalacia Clinical chemistry findings? (4)
v.High PTH

v.High ALP

Low calcium

Low phosphate
What is Paget's disease? (4)
Increased osteoclast and blast activity

Increased bone remodelling

Increases risk of fractures as bone is weak

Sclerosis of bone
Sites affected by Paget's(6)
Pelvis

Skull

Spine (lumbar)

Femur

Tibia

Scapula
Symptoms Paget's (4)
Bone pain

Fractures under minor mechanical trauma

Deafness (usually conductive)

Hats no longer fit properly
Rx Paget's disease (1)
Bisphosphonates e.g. pamidronate, risedronate, zoledronate
What would you expect to see on a bone scan of Paget's?
Something like this, increased bone turnover - especially where osteoclasts are working harder than blasts.

Most commonly affected areas:
skull (deafness)
femur & tibia
lumbar spine
scapula
What would a skull x-ray in paget's look like?
Sclerotic
What does this image show and what is the diagnosis?
Loosers zones or pseudofractures or fractures of insufficiency.

It is a sign of osteomalacia