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9 Cards in this Set
- Front
- Back
Clinical chemistry findings suggestive of Paget's disease? (2)
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High ALP
High PTH |
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Osteomalacia Clinical chemistry findings? (4)
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v.High PTH
v.High ALP Low calcium Low phosphate |
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What is Paget's disease? (4)
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Increased osteoclast and blast activity
Increased bone remodelling Increases risk of fractures as bone is weak Sclerosis of bone |
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Sites affected by Paget's(6)
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Pelvis
Skull Spine (lumbar) Femur Tibia Scapula |
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Symptoms Paget's (4)
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Bone pain
Fractures under minor mechanical trauma Deafness (usually conductive) Hats no longer fit properly |
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Rx Paget's disease (1)
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Bisphosphonates e.g. pamidronate, risedronate, zoledronate
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What would you expect to see on a bone scan of Paget's?
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Something like this, increased bone turnover - especially where osteoclasts are working harder than blasts.
Most commonly affected areas: skull (deafness) femur & tibia lumbar spine scapula |
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What would a skull x-ray in paget's look like?
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Sclerotic
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What does this image show and what is the diagnosis?
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Loosers zones or pseudofractures or fractures of insufficiency.
It is a sign of osteomalacia |