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26 Cards in this Set

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List the antiviral drugs
Valacyclovir HCL
Oseltamivir Phosphate
Acyclovir
List the generic antivirals
Acyclovir
Valacyclovir
Brand name for Valacyclovir
Valtrex
Dosage forms/strs for Valacyclovir
Tabs 500/1000mg
Indications for Valacyclovir
Tx genital herpes
Tx herpes zoster (shingles)
Tx herpes labialis (cold sores)
MoA for Valacyclovir
Valacyclovir is a synthetic acyclic purine nucleotide
Valacyclovir is converted to acyclovir during 1st pass metab.
HSV cells convert acyclovir to active triphosphate form which then interferes with HSV DNA polymerase which inhibits viral DNA replication
DIs for Valacyclovir
Probenecid may dec elimination of Valacyclovir
Contras for Valacyclovir
Renal impairment
Dehydrated pxs (acyclovir may precipitate in renal tubules)
AEs for Valacyclovir
N&V
Headache
Ab pain
PxCx for Valacyclovir
For genital herpes: avoid sex when visible lesions present
Valacyclovir is not a cure
Notify doc if freq/severity does not improve or if px becomes pregnant
Drink lots of fluids during therapy
Brand name for Acyclovir
Zovirax
Dosage forms for Acyclovir
Caps 200mg
Cream 5%
Susp 200mg/5ml
Tabs 400/800mg
Ointment 5%
Powder for injection 50mg/ml
Indications for Acyclovir
Tx chickenpox
Tx genital herpes
Tx HSV-1 and HSV-2
Tx herpes simplex encephalitis
Tx herpes zoster (shingles)
Tx varicella zoster (shingles)
MoA for Acyclovir
Its a synthetic acyclic purine nucleotide
HSV cells convert acyclovir to active triphosphate form which then interferes with HSV DNA polymerase which inhibits viral DNA replication
DIs for Acyclovir
Probenecid may dec elimination of Acyclovir
Contras for Acyclovir
Renal impairment
Dehydrated pxs (acyclovir may precipitate in renal tubules)
AEs for Acyclovir
Caps and tabs: N&V
Ointment: Stinging, burning, pruritis
Injection: Phlebitis, inj site inflammation, transient inc in creatinine lv, rash, hives
PxCx for Acyclovir
For genital herpes: avoid sex when visible lesions present
Acyclovir is not a cure
Notify doc if freq/severity does not improve or if px becomes pregnant
Apply 1/2 inch ribbon of ointment per 4 sq inches of surface area every 3 hours for 7 days
Use rubber gloves to prevent application to other areas
Drink lots of fluids during therapy
Brand name for Oseltamivir
Tamiflu
Dosage forms for Oseltamivir
Caps 30/45/75mg
Powder for oral susp 12mg/ml
Indications for Oseltamivir
Tx acute illness due to influenza infection
Prophylaxis for influenza
MoA for Oseltamivir
Inhibits influenzas neuraminidase
Inhibits virus partical aggregation and release
DIs for Oseltamivir
No clinically significant di's
Contras for Oseltamivir
Not a substitute for the influenza vaccine
Not effective 40 hours after onset of symptoms
Only works on influenza types A and B
AEs for Oseltamivir
N&V
Rare: anaphylaxis
Rare: serious skin rxns (including toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme)
PxCx for Oseltamivir
Take w/o regards to meals
Not a substitute for yearly influenza vaccination
Most effective when started w/in 2 days of symptoms
Refrigerate susp, dont freeze
Finish complete course of therapy