P2 Spring Drug Cards - Antidiabetics

Front 1

Metformin HCL brand/generic

Back 1

Glucophage (XR)
Generic

Front 2

Glipizide brand/generic

Back 2

Glucotrol (XL)
Generic

Front 3

Glyburide brand/generic

Back 3

Micronase, Diabeta
Generic

Front 4

Glyburide with Metformin HCL brand/generic

Back 4

Glucovance
No generic

Front 5

Glimepiride brand/generic

Back 5

Amaryl
Generic

Front 6

Sitagliptin Phosphate brand/generic

Back 6

Januvia
No generic

Front 7

Pioglitazone HCL brand/generic

Back 7

Actos
No generic

Front 8

Insulin Lispro brand/generic

Back 8

Humalog
No generic

Front 9

Insulin Glargine brand/generic

Back 9

Lantus
No generic

Front 10

Insulin (Novolin) brand/generic

Back 10

Novolin
No generic

Front 11

Insulin Aspart brand/generic

Back 11

Novolog
No generic

Front 12

Metformin indication(s)

Back 12

Antidiabetic
NIDDM
Can be used with a sulfonylurea

Front 13

Glipizide indication(s)

Back 13

Antidiabetic
NIDDM (stable or maturity onset)

Front 14

Glyburide indication(s)

Back 14

Antidiabetic
NIDDM (stable or maturity onset)

Front 15

Glyburide with Metformin HCL indication(s)

Back 15

Antidiabetic
NIDDM

Front 16

Glimepiride indication(s)

Back 16

Antidiabetic
NIDDM

Front 17

Sitagliptin Phosphate indication(s)

Back 17

Antidiabetic
NIDDM
Can be used as monotherapy, or combo with metformin or PPAR agonist(thiazolidinedione)

Front 18

Pioglitazone HCL indication(s)

Back 18

Antidiabetic
NIDDM
Used alone, or in combo with sulfonyurea, metformin, or insulin

Front 19

Insulin Lispro indication(s)

Back 19

Antidiabetic
Type 1 or 2 DM

Front 20

Insulin Glargine indication(s)

Back 20

Antidiabetic
Type 1 or 2 DM

Front 21

Insulin (Novolin) indication(s)

Back 21

Antidiabetic
Type 1 or 2 DM

Front 22

Insulin Aspart indication(s)

Back 22

Antidiabetic
Type 1 or 2 DM

Front 23

Metformin HCL MoA

Back 23

Biguanide
Inc's insulin sensitivity
Dec's glucose absorption
Suppresses hepatic gluconeogenesis

Front 24

Glipizide MoA

Back 24

Sulfonylurea
Stimulates insulin synthesis and release from beta cells in pancreatic islets
May improve binding of insulin to rxs, and inc number of rxs

Front 25

Glyburide MoA

Back 25

Sulfonylurea
Stimulates insulin synthesis and release from beta cells in pancreatic islets
May improve binding of insulin to rxs, and inc number of rxs

Front 26

Glyburide with Metformin HCL MoA

Back 26

Biguanide + Sulfonylurea

Front 27

Glimepiride MoA

Back 27

Sulfonylurea
Stimulates insulin synthesis and release from beta cells in pancreatic islets
May improve binding of insulin to rxs, and inc number of rxs

Front 28

Sitagliptin Phosphate MoA

Back 28

DPP4 (dipeptidyl peptidase 4) inhibitor
DPP4 deactivates the incretins GLP-1 (glucagon like peptide 1) and GIP (glucose dependent insulinotropic polypeptide), we want these incretins.

Front 29

Pioglitazone HCL MoA

Back 29

Thiazolidinedione (PPAR agonist)
PPAR regulates the transcription of insulin responsive genes that are critical for glucose and lipid metabolism.
Insulin is req'd for activity

Front 30

Insulin Lispro MoA

Back 30

Usual insulin MoA:
Activates enzymes, promotes transport of glucose across cell membranes, promotes proteins synthesis
Dec's formation of triglycerides
Reversal of aminos 28 and 29 on B chain

Front 31

Insulin Glargine MoA

Back 31

Usual insulin MoA:
Activates enzymes, promotes transport of glucose across cell membranes, promotes proteins synthesis
Dec's formation of triglycerides
Amino acid asparagine at A21 replaced by glycine, and two arginines added to C terminal of B chain

Front 32

Insulin (Novolin) MoA

Back 32

Usual insulin MoA:
Activates enzymes, promotes transport of glucose across cell membranes, promotes proteins synthesis
Dec's formation of triglycerides

Front 33

Insulin Aspart MoA

Back 33

Usual insulin MoA:
Activates enzymes, promotes transport of glucose across cell membranes, promotes proteins synthesis
Dec's formation of triglycerides
Proline at B28 replaced with aspartic acid