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41 Cards in this Set

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amitriptyline brand name?
dose?
Elavil
100-300mg/d
nortriptyline brand name?
dose?
Pamelor
50-150mg/d
imipramine brand name?
dose?
Tofranil
100-300mg/d
desipramine brand name?
dose?
Norpramine
100-300mg/d
doxepin brand name?
dose?
Sinequan
100-300mg/d
clomipramine brand name?
dose?
Anafranil
100-250mg/d
ADRs of TCAs?
blurry vision, sedation, seizures, orthostasis, tachycardia, EKG, weight gain, sexual dysfunction
TCAs for suicidal pts?
smaller doses, more frequent monitoring
TCA DDIs?
2D6, SSRIs, barbiturates, alochol
phenelzine brand name?
dose?
Nardil
15-90mg/d
tranylcypromine brand name?
dose?
Parnate
20-60mg/d
What DDIs with MOAIs can cause hypertensive crisis?
tyramine-containing foods, sympathomimetics, antidepressants, amphetamines, decongestants, meperidine
ADRs of MOAIs?
orthostasis, weight changes, sexual dysfunction
fluoxetine brand name?
dose?
Prozac
10-80mg/d
sertraline brand name?
dose?
Zoloft
100-200mg/d
paroxetine brand name?
dose?
Paxil
20-50mg/d
fluvoxamine brand name?
dose?
Luvox
100-200mg/d
citalopram brand name?
dose?
Celexa
20-60mg/d
escitalopram brand name?
dose?
Lexapro
10-30mg/d
Which SSRI has the longest half-life?
Prozac
ADRs of SSRIs?
GI, weight gain long term, anorexia, headache, insomnia, anxiety, delayed rash, sexual dysfunction
Possible tx for SSRI sexual dysfunction?
bupropion, bethanecol, cyproheptadine, viagra, gingko, yohimbine, drug holiday
SSRIs DDIs?
2D6, Luvox with xanthines, TCAs, MAOIs (contraindicated!!)
Drugs that increase 5HT and may cause serotonin syndrome?
MAOIs, SSRIs, TCAs
amphetamines, cocaine, MDMA
buspirone
bupropion, venlafaxine, nefazodone, trazodone
sumatriptan
levodopa
amantadine
fentanyl, tramadol, meperidine, DXM
lithium
Sx of serotonin syndrome
confunsion, psychosis, hypothermia, BP changes, tachycardia, sweating, rigidity, tremor, seizures, organ failure
MOA of bupropion?
dopamine/NE reuptake inhibitor
ADRs of bupropion?
seizures, headache, irritability, dry mouth, constipation

No CV or sexual side effects
DI of bupropion?
MAOIs
MOA of trazodone?
serotonin reuptake inhibitor
5HT2 antagonist
5HT1 agonist
ADRs of trazodone?
sedation, orthostasis, nausea, priapsm
DI of trazodone?
3A4: triazolam, aprazolam
Advantages of nefazodone over trazodone?
less alpha block, less sedation, no priapsm
MOA of venlafaxine?
serotonin and NE reuptake inhibitor
ADRs of venlafaxine?
sweating, dose-dependent increases in diastolic BP, GI upset
DI of venlafaxine?
cimetidine
MOA of mirtazapine?

dose?
alpha-2, 5HT2 & 5HT3 antagonist

15-45mg/d
ADRs of mirtazapine?
antihistamine, weight gain, dry mouth, decreased WBC
MOA of duloxetine?
serotonin and NE reuptake inhibitor
ADRs of duloxetine?
asthenia & insomnia
What does STAR-D stand for?
Sequenced Treatment Alternatives to Relieve Depression
Agents that can be added to antidepressants to augment tx?
stimulants, modafinil, estrogen, olanzapine, pramipexole, buspirone, levothyroxine, lithium, pindolol, lamotrigine