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19 Cards in this Set
- Front
- Back
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What are the four different neoplasms of the lung and pleura classified by lineage? Most common?
What benign neoplasm mimics new lung cancer? do they calcify? Are they more peripheral or central? Can it be congenital? - What *is* it? Do lung carcinomas calcify? |
Epithelial - most common
melanocytic stromal mesothelial hamartoma - sometimes calcify peripheral > central No, none in newborns. Cartilage in excess and disarray, but the cartilage itself looks normal. No, they don't. |
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What are the 4 malignant epithelial neoplasms? Which three are grouped together for behavioral reasons?
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Squamous cell carcinoma
Adenocarcinoma Large cell undifferentiated carc. --------------------------------------------- small cell undifferentiated carc. |
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What is the major neoplasmic killer of men? Women?
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lung and bronchial cancers
ditto. |
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"Stones bones and groans..." refers to sx associated w/ what diz?
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hyperparathyroid
.. also can show up in squamous cell carcinoma of the lung. --> secrete PTH like compound |
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Do Squamous cell carcinomas show up centrally or peripherally in the lung? Order the freq. of appearance in: bronchi, trachea, and larynx
Do you see desmosomes (intercellular bridges)? Keratin pearls? |
centrally >>peripherally
Bronchi > larynx > trachea Can see either/both. |
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squamous cell carcinomas of the bronchus begin as what?
If you see either desmosomes or keratin, can you dx squamous cell carc? |
dysplasia --> metaplasias.
yes, either is sufficient. |
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What is the most common lung carcinoma in non-smokers? Does it occur more often in smokers?
Central/Peripheral? Glands? Mucin? |
Adenocarcinoma; yes.
Peripheral > central +/- both. :need both to Dx for certain |
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What shows Red on PASd stain? Helps Dx?
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Mucin.
Adenocarcinoma. |
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Is BAC associated w/ smoking? Peripheral/Central?
Outcome better or worse than typical adenocarcinoma? primary or mets? What is more likely if you see multifocal/bilateral dz? Mucinous? |
No.
Peripheral/multifocal/bilateral. Better. Primary. mets, but this is still on the diffdx. Can be either, the dx is not made based on this. |
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If we have a sample that we think is large cell undifferentiated carcinoma, what can help rule out the other similarly-grouped two cancers (squamous and adeno)?
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stain for mucin, look for glands, look for desmosomes, keratin, etc.
LCundiff will have none of these features. |
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What are the three variables that are correlated with prog in non-small cell lung carcinomas?
Are age and histolgy correlated with mortality? |
stage, performance status, weight loss
No. |
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Which carcinoma of the lung can present with ectopic ACTH, ADH, Eaton-Lambert Syndrome (neurological issues), carcinoid syndrome?
Is this cancer typically low or high stage @ presentation? Is it assoc. w/ smoking? Peripheral/Central? Does it often met? Responsive to Chemo/Xrt? Good 5yr survival? |
Small cell carcinoma.
high. Yes. Central in >90%. yes. Yes, but low 5yr survival. |
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Is Small cell carcinoma associated with necrosis? Does it have a high growth factor?
Do it's cells show nucleoli? |
Yes.
Yes. No. |
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Are stage and performance status prog factors for small cell?
Gender, age? # of metastatic sites? |
yes.
all probable. |
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What cancer is associated with asbestos exposure?
Freq site? + for keratin? |
Mesothelioma.
Pleural involvement (diffuse); may have associated effusion. yes. |
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The microvili of an adenocarcinoma are ___ and ___, whereas the microvilli of mesothelioma are ____ and ____.
are ferruginous bodies seen in mesothelioma? |
sparse, short
numberous, long yes |
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Which involve the lung more often: metastases or primary cancer?
Why? |
metastases.
B/c the lung sees all the blood flow. |
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Mets from which sites commonly involve the lung?
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Breast, GI, renal, head/neck
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Most renal mets are ___ type?
ENT mets? primary lung neoplasms? primary pleural neoplasms? mets to lung & pleura? |
clear cell
squamous carcinoma mesotheliomas all lineages possible |
