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25 Cards in this Set

  • Front
  • Back
Epidemiology of Head Injury
Every 5 minutes in US
-one dies, another perm. disabled
Causes of Brain injury
MVA 50%
Falls 21%
Violence 12%
Sports 10%
Causes of Pediatric Head Injuries
64% of infant less than 1yo injury
Risk groups for head injury
m:f 2.5:1
avg age @ injury - 29
ages 15-24
high in persons <5, >64
Predisposing factors to head injury
Alcohol before injury
History of previous TBI
-1 previous 3X risk
-2 previous 8X risk
Definition of Head Injury
Injury to the brain

Documented loss of consciousness

Amnesia of event

Glascow coma scale <15 in first 24 hours

May have residual cognitive, memory, behavioral, physical problems
What are the mechanisms of Brain Injury
Impact Loading - 2 solid objects colliding at considerable velocity
-hammer with head, bullet with head, head on dashboard
-indents skull even w/o skull fracture
-results in cerebral contusions and diffuse axonal injury

Impulse Loading - Sudden arresting of accel/decel but no impoact occurs
-whiplash, explosions
Sources of Brain Injury

Fracture types
Linear or Comminuted fractures - no displacement toward brain
-low velocity objects

Depressed fractures - bone fragments toward brain surface
Sources of Brain Injury

Penetrating Wounds
High velocity, risk of infection
-stick, toy, bullet
Sources of brain injury

CLosed head injuries
Soft brain forced upon hard skull
Gray Matter Contusions

Coup

Contre coupe
Coup - beneath site of impact

Contrecoupe - remote to site of impact
Diffuse White Matter Damage
DAI
Axons severed b/c of shear forces

-extension synnery
Epidural Hemorrhage
Occurs between skull and dura mater

Skull fractures over middle meningeal artery
Subdural Hemorrhage
Rupture of veins of pia mater

Can be slow, geriatric pop.
Subarachnoid Hemorrhage
Pia vessels rupture
Intracerebral Hemorrhages
Ruptured capillaries
Traumatic injury to extracranial blood vessels
Carotid artery and Vertebral Artery
Secondary injury to brain
Vascular changes

Changes in BV endothelium - abnormal dilation/constriction

Compressive Damage - Herniation

Increased ICP
-Normal adult 1-10 mmHg
*Don't lie them flat
>20 dysfunctional
>40 neurological changes

Hydroencepalus

Infection

Seizures - secondary to pressure or scarring

Cascading degeneration (edema)
Systemic Secondary mechanisms of BI
Conditions that compromise oxygen and glucose supply to brain

Most susceptible areas
-BG, Cerebellum, Hippocampus

Causes - Arterial Hypoxemia, Arterial Hypotension, Anemia, Hyponatremia, Hypoglycemia
What is a Stroke?
Sudden onset of a focal Neurological deficit resulting from vascular disease of brain
What is a Transient Ischemic Attack?
<24 hours of sx. 35% of TIA have CVA w/i 5 years.
What is a Reversible Ischemic Neurological Deficit?
Sx lasting >24 hours and <3 weeks
Risk Factors for CVA
BP
Cardiac Disease
Hyperlipidemia
Obesity
Smoking
Drugs
Oral Contraceptives (estrogen)

Age >65 years
M>F
Mexicans, Blacks
Two main kinds of strokes
Ischemic Strokes - caused by lack of blood flow

Hemorrhagic strokes - release of blood into extracellular space
Thrombus vs Embolus
Thrombus - clot formed there

Embolous - formed elsewhere and traveled in blood stream
-most common in left atrium