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10 Cards in this Set

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Other beta lactams are?
Monobactam - Aztreonam

Carbapenems - Impinem, Meropenem
Aztreonam MOA
Aztreonam interferes with biosynthesis of bacterial cell walls by binding to PBPs
Aztreonam activity
only against gram - bacteria
UTI, urosepsis, often hospital acquired.
Moster enterobaceteriaceaa (e. coli, klebsiella)
Modest activity against P.aeruginosa

Poor oral abs. given IM or IV
Poor CSF levels, good tissue and urine.

Combination good for anaerobic and gram +. Metronidazole or clindamycin
Aztreonam general
Exreted via kidneys, reduce dose in renal failure.
No nephrotoxicity and no ototoxicity.
Imipenem MOA
binds with PBP's to lyse cell walls

IV or IM usually IV

NO Nephro or ototoxicity.
Imipenam is combined with?
Cilastatin a potent enzyme inhibitor. Prevents inactivation by the kidney brush border cells.
Impenam activity
Gram + for MSSR, GAS, most pneumococci, many enterococci, strep B.
Gram - for community acquired gram - and most hospital acquired gram -. Most P.aeruginosa.
Anaerobes

NOT GOOD FOR
MRSA, VRE, and some hostpial acquired gram -, meningitis

VERY BROAD ABX BUT DON'T WANT TO SELECT OUT FOR RESISTANCE. BIG GUN. SEIZURES IN HIGH DOSES.
Impenam cannot be used if allergic to what?
Penicillin and/or cephalosporins
Impenam is DOC for?
for certain hospital acquired gram -'s

Enterobacter
Acinetobacter
Citrobacter
Metropenam
just like impenam but side effects are lessened and can be used for CNS infections..
IV use only