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6 Cards in this Set
- Front
- Back
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What defines a good leaving group? (GLG)
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LG = Conjugate base of a strong acid or small neutral molecule
ex. primary F (slow), primary Cl (not fast), primary Br (fast), primary I (very fast) |
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Is hydroxide (OH) ever a leaving group?
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Usually no!!! If it is, it must be combined with pyridine/TsCl first to remove the OH, then with ethanol and the reactant to form the product.
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Sn2 Summary
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Most rapid at Primary, not so good at secondary, NOT AT ALL at tertiary
Solvent - normal (ethanol/water) Dipolar, aprotic are best Nucleophiles vary, neg better than neutral - periodic trends Leaving groups - best are conj bases of strong acids |
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lewis acid
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a substance that accepts an electron pair
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lewis base
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a substance that donates an electron pair
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Sn2 reaction means what so far as configuration?
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sn2 means a change in configuration
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