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30 Cards in this Set
- Front
- Back
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What are the three secretory places after Golgi? |
Plasma membrane, endosome, and the lysosome |
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Protein sorting chart, er lysosome mitochondria peroxisome and nucleus |
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If the smooth ER has more lipids than normal the cell probably ingested a lot of what? And is larger |
Drugs and glucose |
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What are the 4 primary functions of the smooth ER? |
Glucose mobilization (breakdown of glycogen), Ca storage, Drug detox, lipid synthesis |
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In the glucogenolysis pathway what enzyme is attached to the lumenal membrane? |
Glucose 6 phosphatase. G6P can not exit the cell. |
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Deficiency of glucose-6-phosphatase is cause by what disease? |
Van Gierkes disease, no glycogen breakdown. Enlarged kidney and liver and hypoglycemia |
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Ca Atpase does what? |
Pumps calcium into smooth er |
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What binds to receptors 2,8 releasing calcium via TP3 gated 2,3 channels in the sarcoplasmic reticulum? (General answer) |
Hormonal signals and neurotransmitters |
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What does cytochrome p450 use to detoxify drugs in SER? |
O2 and NADPH not da pharmacy. Carcinogens can be mobilized this way |
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What leaflet of SER are phospholopids found? |
Cytosolic (phosphates are needed all over the place in the cell) |
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What is needed to make phospholipids in the SER? |
Acetyl CoA and Glycerol 3 phosphate (need A to poke through membrane) |
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Ceramide (Sara hide) is glycosylated on which leaflet of SER? What makes it up? |
Lumen S(from Sarah) serine and palmitoyl Co A (hides with a pal) |
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Sterols are synthesized on what side of SER membrane by what? |
HMG CoA reductase, on cytosolic side. Committed (stare) mevalonate step (to cholesterol) |
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What leaflet and what substances signals cell death from SER? |
Phosphotidalserine (see tiddies in ER lumen, party gets shut down) lumen (outside) |
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What is exclusive to which leaflets? 2 things |
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Does the rough ER send vesicles to peroxisomes or mitochondria? |
No, both are living |
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ERSS pic |
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N terminal and C terminal membrane proteins in RER |
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What hydrolyzes triglycerides in lipoproteins? |
LPL Lipoprotein lipase |
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What is GPI anchor? RER |
A carb lipid anchor that a protein will be attached to (like RAS) |
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What does lectin do when attached to proteins in RER for cells? |
Promote adhesion, lick it and stick it |
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Dolichol carries 14 chain sugars that are transferred by protein transferase to what on new polypeptide in RER? |
Asparagine (sugars look like asparagus) NH2 |
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What folding properties does the chaperone BIP have? |
Folds hydrophobic inside (bippers don't like water) needs atp to keep warm |
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PDI chaperones do what? |
Promote reDox reactions for Disulfide bonds between two cysteine residues |
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If a protein has disulfide bonds where must it be heading? |
RER or secretory pathway |
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What are the two lectins (chaperones) of the RER and where do they bind sugar? |
Calnexin transmembrane single pass (like cashier working behind the register, next!) Calreticulin in lumen (like space of the rectum). Bind glucose on N-linked oligosacharides |
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What does the chaperone glucosidase do? (In RER) |
Di two so it removes two sugars |
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What does the chaperone glycosyl transferase do? (In RER) |
TRy again. Adds glucose back onto improperly folded proteins |
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ERAD (ER associated degradation pathway) in RER does what? |
Improperly folded proteins get polyubiuitinated and sent to proteasome (p and p) |
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What is cystic fibrosis? |
R for RER f ph f, phenylalanine deletion, improper folding accumulation in proteasome. CFTR doesn't reach target membrane so poor hydration of mucus and stool |
