Oral Pathology Epithelial Pathology

Front 1

A benign proliferation of stratified squamos epithelium resulting in a papillary mass appearing as an exophytic granular to cauliflower-like mass is a?

Back 1

Squamous papilloma (Papilloma)

Front 2

Presumably, this lesion is induced by HPV subtypes 6 and 11?

Back 2

Squamous Papilloma

Front 3

T/F a Squamos Papilloma left untreated will eventually lead to malignancy?

Back 3

False – (there is no malignant potential)

Front 4

A benign, virus-induced, focal hyperplasia of stratified squamous epithelium that produces keratin producing a white surface is?

Back 4

Verruca Vulgaris

Front 5

Common location of verruca vulgaris when oral mucosa is not involved is? When oral mucosa is involved?

Back 5

Hands, vermillion of lip, labial mucosa or anterior tongue

Front 6

A subtype of what virus is found in almost all verrucae?

Back 6

HPV (2, 4, 6, 40)

Front 7

A virus-induced proliferation of stratified squamous epithelium of the genitalia, perianal region, mouth and larynx is?

Back 7

Condyloma Acuminatum (Venereal Wart)

Front 8

What are the HPV subtypes associated with Condyloma Acuminatum?

Back 8

2, 6, 11, 53

Front 9

Multiple, asymptomatic, flat-topped soft nodules which can demonstrate a papillary surface and a cobblestone appearance if clustered would be?

Back 9

Focal Epithelial Hyperplasia

Front 10

What subtypes of HPV cause Focal Epithelial Hyperplasia?

Back 10

13, 32

Front 11

These localized proliferation of the respiratory mucosa can histomorphologically be divided into three types: fungiform, inverted, and cylindrical cell?

Back 11

Sinonasal Papillomas

Front 12

Which of the three types listed above demonstrates the virus?

Back 12

Fungiform

Front 13

A Fungiform papilloma will almost exclusively be found where?

Back 13

Nasal Septum (where it causes unilateral nasal obstruction of epistaxis)

Front 14

The most common sinonasal papilloma is?

Back 14

Inverted (Schneiderian) Papilloma

Front 15

An Inverted Papilloma arises from where?

Back 15

Lateral nasal wall or in a paranasal sinus

Front 16

The least common of the sinonasal papillomas is?

Back 16

Cylindrical Cell Papilloma (Oncocytic Schneiderian Papilloma) Found in maxillary antrum, lateral nasal wall and ethmoid sinus

Front 17

A viral-induced epithelial hyperplasia of the DNA poxvirus group which shows a small central indentation or keratin-like plug is?

Back 17

Molluscum Contagiosum

Front 18

An uncommon lesion found anywhere in the oral cavity which appears as a solitary, pebbly, elevated or depressed lesion would be?

Back 18

Verruciform Xanthoma

Front 19

A very common skin lesion of the older adults representing an acquired bengn proliferation of epidermal basal cells which doesn't occur in the mouth is? Has a stuck-on appearance

Back 19

Seborrheic Keratosis

Front 20

The sudden appearance of numerous seborrheic keratoses with pruritus and associated with internal malignancy is called?

Back 20

Leser - Trelat sign

Front 21

A localized proliferation of sebaceous glands which clinically resembles basal cell carcinomas is?

Back 21

Sebaceous Hyperplasia

Front 22

How can you differ Sebaceous Hyperplasia from Basal cell Carcinoma?

Back 22

If you can squeeze stuff out it is not a Basal Cell Carcinoma

Front 23

A small hyperpigmented macule of the skin that represents a region of increase melanin production not by an increase of melaoncytes is?

Back 23

Ephelis (Freckle)

Front 24

A Benign brown macule caused by chronic UV damage, more common in patients who had freckles as a child is?

Back 24

Actinic Lentigo (Age spot)

Front 25

A form of benign cutaneous melanocytic hyperplasia that is small, sharply demarcated and uniformly colored from tan to brown, of unknown cause, and more common on non-sun exposed areas that is thought to be an early stage of a melanocytic nevus is?

Back 25

Lentigo Simplex

Front 26

An acquired, symmetric hyperpigmentation of the sun-exposed skin of the face and neck associated with oral contraceptive use is?

Back 26

Melasma

Front 27

A flat, pigmented lesion caused by a focal increase in melanin deposition more common on the vermilion of the lower lip is?

Back 27

Oral (Labial) Melanotic Macule (Focal Melanosis)

Front 28

A benign acquired pigmentation of the oral mucosa characterized by dendritic melanocytes dispersed throughout the epithelium is?

Back 28

Oral Melanoacanthoma

Front 29

Malformations of the skin (mucosa) that are congenital or developmental in nature is giving what term?

Back 29

Nevus (Acquired Melanocytic nevus)

Front 30

What clinical stage of Acquired Melanocytic Nevus is the earliest presentation; appears as a brown to black macule, which is sharply demarcated?

Back 30

Junctional nevus

Front 31

What are the three clinical stages of Acquired Melanocytic Nevus?

Back 31

Juctional nevus, Compound nevus, Intradermal nevus

Front 32

What produces the blue color in a blue Nevus?

Back 32

Tyndall effect

Front 33

Leukoplakia, Erythroplakia, and Erythroleukoplakia are all considered what type of oral lesions?

Back 33

Precancerous lesions

Front 34

A white patch or plaque that cannot be characterized clinically or pathologically as any other disease thus leading to a diagnosis via exclusion would be?

Back 34

Leukoplakia (know that this term is strictly clinical and does not imply specific histopathologic tissue alteration)

Front 35

T/F Leukoplakia is the most common oral precancer?

Back 35

True

Front 36

Why is does Leukoplakia show a white color?

Back 36

Thickened surface keratin layer, or thickened spinous layer

Front 37

What precancerous lesion has the highest risk malignant transformation?

Back 37

Erythroplakia (erythroplasia)

Front 38

Is Leukoplakia more common in males of females

Back 38

Males

Front 39

What habit appears to be most associated with leukoplakia development?

Back 39

Tobacco Smoking

Front 40

Leukoplakia is usually associated with what pathology?

Back 40

Actinic Cheilosis

Front 41

Vermillion of the lower lip that is affected with Leukoplakia most likely is due to?

Back 41

UV radiation

Front 42

Which bacteria have been implicated in Leukoplakia?

Back 42

Treponema pallidum (dorsal of tongue in patients with syphilis) and Candida albicans

Front 43

T/F currently HPV there is no conclusive evidence that HPV is associated with oral cancer?

Back 43

True

Front 44

About 70% of oral leukoplakias are found where?

Back 44

On the lip vermilion, buccal mucosa and gingival

Front 45

A special high risk form of leukoplakia characterized by multiple keratotic plaques with rough surface projections althouh initially beginning as a simple flat hyperkeratosis is?

Back 45

Proliferative Verrucous Leukoplakia (almost 100% ---> malignancy)

Front 46

What is different about PVL from Leukoplakia?

Back 46

It is more common in Females and has a minimal tobacco association

Front 47

Malignant transformation potential of a Leukoplakia is related to what two things?

Back 47

Clinical appearance and degree of dysplasia present

Front 48

A red patch that cannot be clinically or pathologically diagnose as any other condition is?

Back 48

Erythroplakia

Front 49

Almost all true erythroplakias demonstrate at least one of three things. What are the three things?

Back 49

Epithelial dysplasia, Carcinoma in situ, or invasice squamous cell carcinoma

Front 50

An epithelium showing a lack of keratin production that is often atrophic, thus showing a red appearance due to underlying microvasculature is characteristic of?

Back 50

Erythroplakia

Front 51

An asymptomatic white fold found in the labial and buccal vestibule of a patient probably means the patient enjoys a little bit of?

Back 51

Smokeless tobacco

Front 52

An oral lesion appearing as an area of opacification with a loss of elasticity possibly due to betel nut, or capsaicin would be?

Back 52

Oral Submucous Fibrosis

Front 53

What is the greatest significance of oral submucous fibrosis?

Back 53

It is a high-risk precancerous condition

Front 54

A common cutaneous premalignant lesion caused by UV radiation to the skin which produces mutations in the p53 suppressor gene is?

Back 54

Actinic Keratosis

Front 55

A slowly developing, premalignant lesion of the lower lip that results from chronic or excessive UV light exposure is?

Back 55

Actinic Cheilosis

Front 56

A self-limiting epithelial proliferation with a strong clinical and histopathologic similarity to well-differentiated squamous cell carcinoma appearing as a well cicumscribed, firm, elevated lesion with a keratin plug is?

Back 56

Keratoacanthoma

Front 57

Approximately 94% of all oral cancers are?

Back 57

Squamous Cell Carcinoma

Front 58

What is different in oral cancers in non-smokers vs. smokers? (who is affected etc.)

Back 58

More likely in females, very young patienets, demonstrate mutations involving the p53

Front 59

What is the significance of alcohol when pertaining to Oral Cancer?

Back 59

It is a significant potentiator or promoter especially when combined with tobacco

Front 60

Oral cancer due to iron deficiency like in Plummer-Vinson Syndrome would most likely be where?

Back 60

Esophagus, Oropharynx and posterior portion of the mouth

Front 61

A radiograph appearing as a "moth-eaten" radiolucency with ill-defined or ragged borders could be diagnosed as?

Back 61

Squamos Cell Carcinoma