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16 Cards in this Set

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  • Back
Most common PRIMARY malignant tumor of bone (after Multiple Myeloma), affecting bone producing (mesenchymal) cells of the knees (teens) jaws (30’s), over 50 = Paget’s. Oral manifestations: malignant Sx’s = pain, swelling, loose tooth, paresthesia.
Classification – based on location or histo
Radio: little change or irreg wide PDL, radiolucent +/- radiopaque, “sun-ray” periosteal rxn.
Histo: malig CT cells producing bone
TMT: Surgery w/ negative margins
Prog: 5 yr – 60%, distant metastases or recur
Most common PRIMARY malignant tumor of bone (after Multiple Myeloma)
Irreg restructuring of bone (excess irreg. bone), > 50 yrs, elev serum alkaline phospatase, Histo: mosaic pattern, “reversal lines”, Radio: “cotton wool.”
Radiographic: "Cotton-wool"
Malignant cartilage-producing cells, esp anterior maxilla. Benign cartilage lesions = UNCOMMON assume malignant.
Radio: like osteosarcoma, +/- speckled (flocculant) radiopacities
aggressive variant of Chondrosarcoma, jaws
TMT: surgery alone
Mesenchymal chondrosarcoma –
Malignant cartilage
Malignant tumor of “small round blue cells” affecting YOUNGER patients. 25% have metastasized to lung/other bone (diaphysis of long bones, jaws) at Dx. Radio: non-specific, +/-“moth-eaten” RL. Tx: Metastatic workup, surgery, chemo. Prog: 5 yr – 60%.
Ewing’s Sarcoma(bone)/Primative Neuroectodermal Tumor(soft tissue)
Malignant single plasma cell neoplasm, > 50 yrs. Bone destruction à bone fractures/pain, hypercalcemia à metastatic calcification, renal damage – Bence-Jones proteins in urine, little normal marrow (anemia, leucopenia, thrompocytopenia), amyloid deposition à macroglossia, organ damage. “Punched out” RL’s – non-corticated (in children = Langerhan’s) Tx: Chemo, steroids, bisphosphonates – NO SURGERY.
Multiple Myeloma
ingle sight of bone destruction, ~50% à MM
TMT: full body X-ray to r/o MM, (radio/chemo)
Solitary Plasmacytoma of Bone
Jaw bones - ill-defined/subtle RL, alveolar bones lass, vague pain, parasthesia! Tx: NO SURGERY, Radiation (localized), Chemo (advanced), if low grade – no Tx.
Non-Hodgkin Lymphomas
Treatment for Multiple Myeloma includes Surgery? True/False?
Aggressive, chromosomal translation. Prog: curable – chemo. Histo: “starry sky” 3 types:
1. Endemic African variant: max & mand, mult quadrants, kids, EBV.
2. Sporadic: N Amer/Europe, <10% jaw
3. Immune: esp HIV
Burkitt Lymphoma:
Metastatic Tumors to Bone (overview):
Metastatic Dx to bones (primarily carcinoma) > osteosarcoma in adults.
Most common types: breast, lung, prostate, colorectal, & renal cell carcinoma.
Most common location: hematogeous à mandible (except chondrosarcs and AOT’s), also to gingiva (looks like pyogenic gran).
Can be 1st sign of malignancy.
Clinical: bone pain, loose teeth, paresthesia, swelling, mass.
Radio: poorly defined RL, beware of “isolated perio.”
Prog: very poor.
Rare neoplasm of Langerhans (APC’s) – originate in bone marrow à epidermis, thymus, GI, oral mucosa of Young children.
Prog: goodà poor depending on distribution.
Clinical: Varied, bone pain, multiple osteolytic lesions of skull/jaw (in jaw ill-defined, “local pero defect”), skin rashes, oral ST lesions
Histo: SEM Birbeck granules – tennis racket shape
Langerhans Cell Histocytosis