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17 Cards in this Set
- Front
- Back
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Which group has increasing incidence and mortality?
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Black Females
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What is the RR for those with ADH3 variant?
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40
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Which ADH variant give 5X the risk for oral cancer?
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ADH3
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Oral Cancer rates are increasing in a few states, which state was highest?
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NV
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Heavy Smokers’ chances of abnormally high EGFR?
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80-100%
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Key signals activated by smoking include all except?
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E6/E7 (HPV)
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Which is not one of the major changes at a molecular level due to smoking?
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EGF gene mutation
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Which is upregulated in 25-70% of all oral cancers?
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Cyclin D-1
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Which is not a result of smoking induced DNA methylation?
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G to A transversion
(G to T in smoking) |
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GA tranversions in P53 occurs in?
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non smokers
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GtoT transversion common in?
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smokers
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P53 hotspots of exon 248 and 273 are hot because?
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CpG rich exons
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9p24 and 3p12 are located on which arm?
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SHORT ARM "p"
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VEGF are upregulated by what pathway?
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EGFR
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Colon and oral cancer can be caused by what dietary supplement?
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folate
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T or F…Every serving of fruit and veggies decreases risk for oral cancer?
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T
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Dr. Kingsley presents to your office with low levels of p14/p19, FHIT, p53 and high levels of CyclinD-1 and bcl-2…what stage is his oral cancer?
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late stage
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