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173 Cards in this Set
- Front
- Back
- 3rd side (hint)
Diploid Number of Chromosomes?
-How many are Sex Chromosomes? -What is the # of Autosomes? |
46 chromosomes total
-23 Mother -23 Father 2 are Sex Chromosomes 44 Autosomes (22 mother + 22 father) |
Mother + Father
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Fusion of the Male and Female Germ Cells?
Spermatozoa and Ova are called what? 2 Gametes fuse to make a ___? |
Fertilization
Gametes Zygote |
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Define Meiosis?
Define Mitosis? |
Meiosis- process by which germ cells are produced
-cell has 1/2 the chromosome # (23) Mitosis- division of somatic cells -cells will be identical to parent cell (46) |
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Before Mitotic Division is done the amount of DNA is doubled leading to ___ times the amount that should be is the cell
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4X- Tetraploidy
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Name some of the defects that can be see in someone that has triosomy 13 (Down's Syndrome)
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Facial Clefts
Shortened Palate Protruding Fissured Tongue Delayed Eruption of the Teeth |
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Can Trisomy and Monosomy occure in Sex Chromosomes?
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YES
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Name 3 Autosomal Dominant Conditions?
-Only one parent needs to have the disorder in order for it to manifest,...it will be shown in EVERY Generation and 1/2 of the children |
Achrondoplasia
Cleidocranial Dysostosis Osteogenesis Imperfecta *Amelogenesis Imperfecta (in some cases) |
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Name 1 Autosomal Recessive Inheritance
-Can only express itself when both parents have gene |
Chondroectodermal Dyslpasia
*Microcephaly *Cystic Fybrosis |
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Teratolygy
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Study of Genetic Defects
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What are the 2 stages of Prenatal development?
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Embryonic Stage
Fetal Stage |
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Can Trisomy and Monosomy occure in Sex Chromosomes?
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YES
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Name 3 Autosomal Dominant Conditions?
-Only one parent needs to have the disorder in order for it to manifest,...it will be shown in EVERY Generation and 1/2 of the children |
Achrondoplasia
Cleidocranial Dysostosis Osteogenesis Imperfecta *Amelogenesis Imperfecta (in some cases) |
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Name 1 Autosomal Recessive Inheritance
-Can only express itself when both parents have gene |
Chondroectodermal Dyslpasia
*Microcephaly *Cystic Fybrosis |
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Teratolygy
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Study of Genetic Defects
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What are the 2 stages of Prenatal development?
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Embryonic Stage
Fetal Stage |
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Prenatal Development consist of 2 stages, NAME THEM?
Name all substages |
Embryonic
-Cellular Proliferation// Migration - Morphogenesis (Differentiation of all internal and external organs Fetal Stage |
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How long is the embryonic stage?
How long is the fetal stage |
Embryonic Stage= 8 weeks
-CP and Migration (0-4) -M/D (4-8) Fetal Stage= 5 weeks- birth -Growth and Maturation of fetus |
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Most tissues develop between interaction between ___ and ___?
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Epithelium and Mesenchyme
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Name the 3 tissue interactions that must occur in order for development to occur?
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Induction: initiates differentiation
Competence: cell must be able to respond Differentiation |
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Formation of a 3 layered embryo begins after fertilization undergoes a series of divisions leading to the formation of a ball of cells known as the _____.
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Morula
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After Cavitation the morula is called ____.
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Blastocyte
-a blastocyte is formed when fluid seeps into the morula |
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What are the two cell populations of the blastocyte.
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Trophoblast-Line the cavity
-form primary yolk sac Embryoblast- small cluster of cells w/in the blastocyte |
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Embryoblast cells form the ____ and the Trophoblast cells form _____.
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Embryoblast >>Embryo Proper
Trophoblast>> (Assoc. w/ implantation of the embryo) Placenta |
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What happens at Day 8 of Gestation (Period of development)
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Cells of Embryoblast Differentiate into a 2 layer disk called the Bilaminar Germ Disk
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The differentiated Embryoblast Cells become what dorsally and what ventrally.
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Dorsally- Ectodermal cells that are columnar and will reorganize to form AMNIOTIC CAVITY
Ventrally- Endodermal Cells are Cuboidal and will form a 2ndary Cavity (2ndary Yolk Sac) |
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At what stage is the axis of the embryo determined?
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During the time that the inner cell mass (embryoblast) is differentiating into ectodermal and endodermal layers
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How long does it take for the differentiation of the inner cellualar mass to take place?
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2 weeks
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On the Dorsal side of the embryo where the ectoderm is forming what 2 structures can be seen at the midline?
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Prochordal Plate: Future head of embryo
Primitive Streak: midline structure formed by ectoderm |
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What is the last event that happens during the Embryonic Phase I
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Mesoderm forms from the invagination of the ECTODERM and spreading LATERALLY between endo and ectoderm
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What happens during the 3rd week of development
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Development of the Trilaminar Disk
- Mesoderm formation |
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How and Where does the Notochord form?
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Ectodermal Cells at the Primitive Node (rostral part of primitive streak) divide and migrate between the endoderm and the ectoderm >>> solid column is formed at the midline >>> column pushes as foward toward prochondral plate (will be head of embryo)
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Ectodermal cells that will form the mesoderm migrate laterally and forward around what structures
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Notochord and Prochondral Plate
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What two structures seperate the Endoderm from the Ectoderm after the migration of cells
What is the exception? |
Notochord and Mesoderm
The exception is the at the tail end of the embryo (cecal plate) |
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When the cells migrate are anterior to the Prochodral Plate they will form what structure?
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Cardiac Plate>> form heart
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What happens during the 3rd week of development
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Development of the Trilaminar Disk
- Mesoderm formation |
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How and Where does the Notochord form?
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Ectodermal Cells at the Primitive Node (rostral part of primitive streak) divide and migrate between the endoderm and the ectoderm >>> solid column is formed at the midline >>> column pushes as foward toward prochondral plate (will be head of embryo)
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Ectodermal cells that will form the mesoderm migrate laterally and forward around what structures
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Notochord and Prochondral Plate
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What two structures seperate the Endoderm from the Ectoderm after the migration of cells
What is the exception? |
Notochord and Mesoderm
The exception is the at the tail end of the embryo (cecal plate) |
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When the cells migrate are anterior to the Prochodral Plate they will form what structure?
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Cardiac Plate>> form heart
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Embryonic Stage II involves ___ and ___.
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Differentiation and Morphogenesis
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Major tissues and organs will differentiate from ____.
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Trilaminar Disk
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Why is phase II important to dentist?
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B/c it is during this stage that the Head, Face and Teeth Develop
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During Embryonic Phase II there is differentiation of the ___ and ___ from ectoderm and differentiation of ____.
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Nervous System and Neural Crest Cells from Ectoderm
Differentiation of the Mesoderm |
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The hallmark of phase II of the embryonic stage of fetal development is what?
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Folding of the embryo into 2 axes (rostrocaudal//lateral)
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What is the first event that happens in Nervous System Development?
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Thickening of the Ectoderm at the rostral end to form the Neural Plate
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The neural plate will rapidly form raised margins calle ___.
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Neural Folds
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This structure is created as a result of the neural folds continuing to rise.
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Neural Groove
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When the Neural Folds fuse together they will form what structure?
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Neural Tube
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The Neural Tube will expand and become what 3 structures?
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Forebrain, Midbrain, Hindbrain
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While the Nervous System is developing the ___ is differentiating.
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Mesoderm
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The Mesoderm thickens on each side of the ____ to form the _____.
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Midline; Paraxial Mesoderm
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The Paraxial Mesoderm in the trunk breaks into segmented blocks called ____.
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Somites
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Can you name the 3 components of a somite?
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Sclerotome: 2 adjacent vertebrae and disks
Myotome: Segmented mass of muscle Dermatome: Ct of the skin over the somite |
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In the head the paraxial mesoderm partially or fully segments to form ____.
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Partially segments to form Somatomeres
-Some of the Head Musculature |
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Paraxial Mesoderm of the ____ remains thin and is AKA Intermediate Mesoderm. It will become the Urogenital System
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Periphery
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What is the Urogenital System
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Urinary and Genital Structures
-Kidney, Bladder, Ovaries, Vagina, Penis etc... |
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The Lateral Paraxial Mesoderm will form into 8 different structures name 2 systems and 2 organs that orginate from this layer
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Cardiovasular and Lymphatic System
Adrenal Cortex Spleen |
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The other 5 structures that orginate from the the lateral paraxial mesoderm are
-___ associated w/ Muscles and Visera -Serous Membrane of ____. -Peri____ and Per_____ -_____ and _____ cells |
CT associated w/ Muscles and Visera
Serous Membrane of Pleura Pericardium and Peritoneum Blood and Lymphatic Cells |
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Folding of the Embryo occurs in what two dimensions?
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Rostrocaudally and Laterally
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Head fold in crucial for the development of the _____.
-This is the Rostrocaudal Fold |
Primitive Stomatodeum
(future oral cavity) |
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This layer lines the oral cavity?
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Ectoderm
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Stomatodeum seperates from gut via the _____.
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Buccopharyngeal Membrane
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The purpose of the lateral fold is what?
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Mesoderm is deposited and Endoderm will form gut
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Where do the Neural Crest cells come from?
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As the neural tube is forming a group of cells decide to do there "own thing" and seperate from the Neuroectoderm
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What do Neural Crest cells do after they differentiate from Neuroectoderm?
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Migrate and Differentiate extensively in the developing embryo
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What do the Neural Crest cells become when they differentiate?
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Spinal and Sensory Ganglia
Schwann and Pigment Cells Meninges Sympathetic Neurons CT of Head |
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What is the CT of the head called?
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Ectomesenchyme
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What is the CT everywhere else in the body except the head called?
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Mesenchyme-b/c it comes from Mesoderm
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What does Cephalogenesis mean
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Formation of the head
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Formation of the Primitive Mouth
-Structures that surround the stomadeum in the beginning --Rostrally? --Caudally? --Laterally? |
Rostrally- Neural Plate
Caudally-Cardiac Plate Laterally- Brachial Arches |
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Buccopharyngeal Membrane seperates the ____ from the ___.
-Will this connection always exist |
Stomatodeum from the Foregut
-No this connection will not always exsist b/c it will break down later |
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The Brachial Arches form the ____ b/c of the proliferating ____.
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Pharyngeal Wall b/c of the proliferating lateral plate mesoderm
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How many brachial arches will form/
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6
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Do all 6 brachial arches appear in humans?
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No
-The 5th and 6th are transient structures, meaning they appear briefly and then disappear |
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The Brachial Arches are seperated externally by ____ and internally by ______.
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Brachial Grooves;Pharyngeal Pouches
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What is the function of the Brachial Arches
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To seperate the stomatodeum from the developing heart
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Are all 3 layers present in the Brachial arches?
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Yes
-Outer: Ectoderm -Inner: Endoderm -Core: Mesoderm |
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When the Neural Crest Mesenchyme (CT)and some other mesenchyme condenses a bar of cartilage is formed and differentiates. This bar is known as ____.
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Arch Cartilage
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How many arch cartilages exsists? What are there names, associated muscles and nerves?
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Two
-1st Arch Cartilage-Meckel's Cartilage: (Striated) Muscles of Mastication and Trigeminal Nerve 2nd Arch Cartilage-Reichert's Cartilage: (Straited) Muscles of Facial Expression and the Facial Nerve |
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Give the Innervation of the Brachial Arches (1-3)
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1st- Trigeminal
2nd- Facial 3rd- Glossalpharyngeal |
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The 1st, 2nd, and 3rd Brachial Arches contribute to what?
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Face, Mouth, and Tongue Development
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What are facial processes
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swellings of mesenchyme that fuse to form the face
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T or F: Elimination of a furrow will form the face.
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True
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Where in the head does the fusion of a process still produce a furrow?
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Palate
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With morphogenesis of the face, what are the new limits of the Stomatodeum?
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Frontal, Maxillary, Mandibular Processes
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Proliferation and Migration of the Ectomesencyme form the _____.
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Primitive Nasal Cavities
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Thickenings in Ectoderm of Frontal Promience are called _____.
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Olfactory Placodes
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With Rapid proliferation of underlying mesenchyme around placodes 3 structures form. Name them?
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Lateral Nasal Process
Nasal Pit Medial Nasal Process |
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The area where the lateral and medial nasal processes develop, along with the nasal pit is called _____.
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Frontonasal Process Region
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The Lateral Nasal Process and the Maxillary Process will form this IMPORTANT structure?
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Nasolacrimal Duct
-CRY!!! |
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The Medial Nasal Process and the Frontonasal Process will fuse to form what 3 structures?
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Middle portion of Nose and Upper Lip
Ant. Portion of Maxilla Primary Palate |
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How is the Upper Lip formed?
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The Medial Maxillary Process pushes on the Medial Nasal Process towards the midline superiorly
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How is the Lower Lip formed?
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Ectomesenchyme of the Mandibular Process pushes towards the midline inferiorly
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When does the formation of the primary epithelial band occur?
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24-38 days of gestation
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Is there a Secondary Palate in all species?
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NO
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What is the purpose of the secondary palate?
-the primary palate can not do this! |
Seperate Oral Cavity from Nasal Cavity
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Initially in development the oral and nasal cavities are bounded anteriorly by the ____ and occupied by the ___.
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Primary Palate; Tongue
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When does the formation of the secondary palate begin,...end?
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7-8 Week of development; 3 monthes (about 12 weeks)
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In the development of the secondary palate 3 outgrowths occur in the oral cavity. Name them?
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Nasal Septum
Palatine Shelves |
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The Nasal Septum grows downward from the ______ along the midline. While the Palatine Shelves grow from the _____ along the midline
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Frontonasal Process; Maxillary Process
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What is the movt of the palatine shelves when they begin to take there position.
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Project Downward on each side of the Midline
Tongue w/draws from between shelves Shelves ELEVATE and FUSE above the tongue and with Nasal Septum |
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When the Nasal Septum and Palatine Shelves fuse along the midline this does what?
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Seperates the Oral and Nasal Cavities
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This event must occur in order for the palatine shelves to merge properly
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Elimination of Epithelial Covering (seam)
-DNA Syntheses ceases 24-48 hours before adhesion |
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What is cleft palate? What are its types?
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When the palatine shelves dont fuse
-Syndromic: like in Triosomy 13 -Non-Syndromic: Isolated Event |
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When is the Epithelial Seam eliminated?
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When epithelium transforms into mesenchyme
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Cleft palate occurs _____ b/c fusion occurs ____.
*Normally |
Laterally; Laterally
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Molar and Premolar come from the ____ everything else comes from the ____.
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Maxilla; Mandible
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T or F:An appliance can be placed between palatine shelves to create more room for teeth to align correctly.
-If true up to what age? |
True; Up to age 17
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T or F: It doesnt matter at what time or age an implant is done?
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False; Bone development must be fully completed or the implant will move
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Formation of the Tongue begins with the ____ meeting at the midlin under the primitive mouth
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Pharyngeal Arches
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Proliferation of the Mesenchyme creates swellings in the mouth called what?
These swellings occur at the midline in the _____. |
Tuberculum Impar
Midline of Mandibular Process |
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Tuberculum Impar is connected to 2 bulges called what?
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Lingual Swellings
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Lingual Swelling enlarge and fuse w/ Tuberculum Impar to form what?
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Anterior 2/3 of Tongue
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What arch is the anterior 2/3 of the tongue derived from?
-Innervation? |
Arch I
-innervated by the trigeminal nerve |
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Root of the tongue arises from the ____.
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Hypobrachial Eminence (anterior copula)
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What arch is the root of the tongue (posterior 1/3) derived from?
-Innervation? |
Arch III
-Glossalpharyngeal |
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Is the 2nd arch involved in tongue development?
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No- b/c IIIrd arch overgrows IInd and IIIrd and Ist fuse
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The hypobrachial eminence is divided into 2 divisions.
-Name them and what they give rise to? |
Anterior Copula- posterior 1/3 of tongue
Hypobrachial Eminence- Epiglottis |
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Muscles of the Tongue come from where?
What is the motor innervation of the tongue |
Occipital Somites
Hypoglossal |
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What are the 3 components of the skull?
Which of the answers develops via endochondrial ossification |
Cranial Vault
Cranial Base -Endochondrial Ossification Face |
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Membranous Ossification means?
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Bone formed directly from mesencyme w/ NO cartilage precursor
-Cranial Vault and Face |
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Which of the 3 components of the face is the last to form
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1st- Vault
2nd-Face 3rd-Base |
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What Brachial Arch does the Mandible and Maxilla develop from?
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1st Brachial Arch
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Mandible forms w/in the ____ and Maxilla forms w/ in the ____.
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Mandibular Process
Maxillary Process |
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In Primitive Vertebraes ____ of the 1st Brachial Arch forms the _____.
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Meckle's Cartilage; Lower Jaw
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T or F: In Humans Meckle's Cartilage contributes to the development of the Mandible.
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False- there is only a close postional relationship, MC doesnt contribute to the development of the lower jaw AT ALL!
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Meckle's Cartilage is what type of Cartilage
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Hyaline
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Mandibular Branch of the Trigeminal Nerve innervates Meckle's Cartilage at the beginning 2/3. It then divides into ____ medially and _____ laterally in relation to the cartilage.
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Medially- Lingual Nerve
Laterally- Inferior Alveolar Nerve |
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The Inferior Alveolar Nerve will divide into ___ and ___.
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Incisor and Mental Nerves
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The ____ aspect of Meckel's Cartilage condenses (mesenchyme) where?
Wk:6 |
Lateral; Angle where the inferior alveolar nerve separates into Incisor and Mental Nerves
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Wk: 7
Intermembranous Ossification results in what |
First bone of the Mandible to develop- BODY!!!
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After Ossification; Meckel's Cartilage regresses except where?
What does this structure develop into? |
Posterior Part
-Malleus of Middle Ear -Sphenomandibular Ligament |
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Name the 3 Secondary Cartilages that give rise to the rest of the mandible
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Condylar
Coronoid Symphyseal - Give rise to the Ramus and Symphysis of Mandible |
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What is the TRUE purpose of Meckle's Cartilage besides Malleus of Middle Ear and SML
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Forms Canal of Mandibular Nerve
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The Maxilla is formed from the ____ and ____.
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Premaxilla (frontonasal processes)
Zygomatic Processes |
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Congenital Defects will lead to these 2 things?
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Cleft Palate and Syndromes of the Head and Neck
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What role do Neural Crest Cells play in the development of tooth structure?
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NC cell migrate onto facial structure and participate in development by communicating with the epithelium
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T or F: Closure of the palatine shelves and tooth development occur at different times?
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False
-Occur at the same time |
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Define Ectomesenchyme
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CT that NC cells have migrated into
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Tooth development is a result of interaction between ___ and ____.
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Epithelium and Mesenchyme
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What time does the primary epithelial band occur?
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24-38 days of Gestation
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What is the significance of the primary epithelial band?
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It will thicken and develop into the future dental arches (upper and lower)
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Due to a change in Mitotic Spindle the cleavage plane of the cells of the primary epithelial band change. This allows the epithelial band to develop into two things. Name them
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Vestibular Lamina
-future vestibule between cheek and tooth bearing area Dental Lamina -future site of teeth |
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T or F: The Dental Lamina develops behind the Vestibule Lamina.
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True
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It is within the ____ that the 3 stages of tooth development take place.
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Dental Lamina
-Bud -Cap -Bell |
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Initiation of tooth development comes from ____ and ___.
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1st Arch Epithelium + NC cells = Tooth Development
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Bone can develop from what?
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Any epithelium and NC cells
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Odontogenesis is initiated by factors in the ____ that will influence the _____. But as time passes the ____ will influence odontogenesis.
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First Arch Epithelium;
Ectomesenchyme; Ectomesenchyme |
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Bud Stage
-Name the 5 steps |
Series of Epithelial-Mesenchyme interactions
Mesenchymal Cells surround tooth bud, condense and proliferate Epithelium becomes competent to the signals from ectomesenchyme Epithelium Proliferates Epithelial Bud Forms |
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In the transition from Bud to Cap Stage there are morphogenic changes that occur that will give rise to what?
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Different Teeth
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The BM is made up of type ___ collagen and ___.
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Type IV and Laminin
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If there is a defect in the dental lamina then what will happen?
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There will be and absence of a tooth
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___ seperates CT from Epithelium.
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Basement Membrane
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NC cells in the Dental Follicle will make what 3 structures of the tooth
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Cementum
PDL Alveolar Bone |
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Dentin is of ___ orgin while Enamel is of ___ orgin.
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Dentin: CT
Enamel: Epithelial |
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Cap Stage
-It is at this stage that dentin and enamel ___ begin expression |
Genes
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Cap Stage
-Epithelium cont to proliferate into ectomesenchyme -Cell density of ectomesenchyme increases. This is called ___. -When the tooth bud begins to look like a cap sitting on a ball of ectomesenchymal cells 2 structures are distinguishable. -What is the Cap -What is the ball of cells |
Condensation
-Cap:Dental Organ= Enamel -Ball of Cells: Dental Papilla= Dentin and Pulp |
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The Dental Follicke limits the ___ and encapsulates___. It is the future of ____.
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Limits:Dental Papilla
Encapsulates:Dental Organ Future of Periodontal Tissues |
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Enamel Knots form what?
___ has a role in cusp pattern formation |
Cusps
-FGF-4 |
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Bell Stage is AKA what?
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Histodifferentiation- Ameoloblast and Odontoblast aquire phenotype
Morphogenesis-crowns take shape |
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Bell Stage
-Enamel Organ cells become ___ and form the ____. Cells next to the dental papilla become ___ and form the _____. -This layer has a high ___ content and is associated w/ the formation of ____. |
Cuboidal; Outer Enamel Epithelium
Columnar; Inner Enamel Epithelium; Glycogen; Enamel |
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Bell Stage cont:
Cervical Loop is what? -Future? -If problems occur? |
Region where IEE an OEE meet at the rim of the dental organ
-Future Sulcus -Periodontal Problems result |
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Bell Stage cont:
-The Stellate Reticulum is between the ___ and ___ and does what? This layer has high ___ content to pull water into organ. |
OEE and IEE
-provides Ca and phosphorus to enamel -GAG |
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Stratum Intermedium is where?
-High ____ activity |
between the IEE and SR
-Alkaline Phosphatase Activity |
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These twol layers work together to form enamel?
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IEE and SI
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Bell Stage is determined when what two things happen?
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Dental Lamina Breaks Down
Crown Patterning Determination |
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State the Vascularization and Innervation of
-Dentin -Enamel -Pulp |
Enamel
-Not V or I Dentin -Not V, but is I Pulp -V and I |
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Crown Stage
-What marks the begininng of the crown stage? |
Formation of Dentin
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When does dentin formation start?
-Where? |
At the end of the BEll Stage
-IEE and areas of cuspal development |
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What is the role of the IEE in dentinogenesis?
|
organizing activity (inductive signal) from BM to the cells of the mesenchyme
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Process of Amelogenesis
-When -Where |
Crown Stage
At tip of cusp |
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Whatis the Nutritive supply during amelogenesis?
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SI, SR and collaps of Enamel organ
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Secretion of Matrix in Dentinogenesis is ____ and in Amelogenesis is ____ and ____.
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Collagen Type I
Amelgenin and Enamelins |
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