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4 Cards in this Set
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- Back
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Morphine
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Schedule II
First pass effect, requires higher oral doses Oral = 60 min IV = 10-20 min IM = 30 min SubQ = 60-90 min Half life 2-4 hrs Duration 5-7 hrs oral route |
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Naloxone
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Antagonist = competes with opiods for receptor sites to neutralize their effects
Used to reverse or block opioid-induced analgesia, treat depression of CNS or respiratory system. Used to reverse opioid overdosing! Onset of action within min IV, IM, SubQ Repeated doses needed bc action is shorter 1-2 hrs Should be readily available whenever opioids are given. |
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Fentanyl
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Schedule II
Used for preanesthetic or post-op pain IV or epidural treatment of pain = transdermal patch (slow onset 12-24 hrs) delivers drug for 3 days High risk of respiratory depression |
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Meperidine
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Synthetic drug
Schedule II Produces IRREVERSIBLE neurotoxic metabolite normeperdine, not recommended for therapeutic use bc hallucinations/seizures Contraindicated in pts taking amphetamines or MAOIs bc Serotonin Syndrome (excitation, fever, seizures, death) Only for short term in healthy individuals. |
