Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
28 Cards in this Set
- Front
- Back
|
Role of IL-7
|
Main progenitor that stimulates the early development of B and T Cells
Particulay T Cells Proliferation before antigen receptor rearrangement Rsulting in marked increases in cell numbers |
|
|
Deficiency of IL-7
|
Causes severe combined immunodeficiency (SCID)
Profound deficiency in mature B and T cells |
|
|
What is the key event in lymphocyte development?
|
Tge rearangement of antigen receptor genes
Drives the genreation of a diverse repertoire In order to be expressed they must rearrange |
|
|
What is the commitment for B Cell lineage? Pro Stage
|
Ig heavy chain
Succesfull production marks the transition to the Pre B Cell Stage |
|
|
What is the commitment for T Cell lineage? Pro Stage
|
TCR Beta chain
Succesfull production marks the transition to the Pre T Cell Stage |
|
|
Stem Cell Surface Marker Expression and Cellular Function?
|
Surface marker CD43+
None |
|
|
Pro-B Surface Marker Expression and Cellular Function?
|
CD43+, CD19+, CD10+
None |
|
|
Pre-B Surface Marker Expression and Cellular Function?
|
B220, CD43+
None |
|
|
Immature B Surface Marker Expression and Cellular Function?
|
IgM, CD 43-
Negative Selection (deletion), receptor editing Becomes this after successful rearrangement of heavy & light chains |
|
|
Mature B Surface Marker Expression and Cellular Function?
|
IgD+, IgM+, CD23+
Activation (proliferation and differentiation) |
|
|
What do RAG-1 and RAG-2 genes do?
|
Their protein products mediate recombination
|
|
|
When can IgM be made?
|
When there is succesful rearrangement of a light chain gene
|
|
|
What happens to a Immature B cell that interacts with a antigen?
|
Considered a self antigen and is destroyed
|
|
|
Multiple Myeloma
|
Plasma cells in the bone marrow
Bens-Jones proteins found in the urine |
|
|
ALL: Acute Lymphatic Leukemia
|
Common in children
Usually successful treatment Found in bone marrow and blood |
|
|
Waldenstroms Macroglobulinemia
|
Massive amounts of IgM produced
|
|
|
Hodgkins Lymphoma
|
Germinal center B cell
|
|
|
Burkitts Lymphoma
|
Causeed by Epstein-Barr
Overexpression of MYC |
|
|
What ensures recognition of MHC Class I and II in T Cells?
|
Positive selection events
|
|
|
Stem Cell Surface Markers and Cellular function for T Cell
|
C-Kit+, CD44+, CD25-
None |
|
|
Pro-T Surface Markers and Cellular function for T Cell
|
C-Kit+, CD44+, CD25+
None |
|
|
Pre-T Surface Markers and Cellular function for T Cell
|
C-Kit+, CD44-, CD25+
Pre-T receptor (Beta chain/pre-T alpha) |
|
|
Double Positive Surface Markers and Cellular function for T Cell
|
CD4+, CD8+, TCR/CD3
Membrane alpha/beta TCR Positive and Negative Selection |
|
|
Single Positive (Immature T Cell) Surface Markers and Cellular function for T Cell
|
CD4+, CD8- or CD4-, CD8+, TCR/CD3
Membrane alpha/beta TCR |
|
|
Naive Mature T Cell Surface Markers and Cellular function for T Cell
|
CD4+, CD8- or CD4-, CD8+, TCR/CD3
Membrane alpha/beta TCR Activation |
|
|
RAG expression of T Cell development
|
Occurs between Pro T and Pre T
and at the beginning of Double Positive T |
|
|
What does a T Cell become if it sees MHC Class I or Class II
|
Class I = CD8+
Class II = CD4+ |
|
|
Mycosis Fungoides
|
Characteristic cell surface marker CD3/TCR
CD4 or CD8 Located in the periphery |
