One Liners Histamines/serotonin/ergots

Front 1

Disease caused by excess ergot alkaloids

Back 1

St. Anthony's fire

Front 2

Endogenous substances commonly interpreted as histamine, serotonin, prostaglandins, and vasoactive peptides

Back 2

autocoids

Front 3

Syndrome of hypersecretion of gastric acid and pepsin usually caused by gastrinoma; ass'd with severe peptic ulceration and diarrhea

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Zollinger-Ellison Syndrome

Front 4

Drug that causes contraction of the uterus

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Oxytocin

Front 5

Distribution of histamine receptors H1, H2, and H3

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Smooth muscle; stomach, heart, and mast cells; nerve endings, CNS respectively

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Prototype antagonist of H1 and H2 receptors

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diphenhydramine and cimetridine, respectively

Front 7

1st generation antihistamine that is highly sedating

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diphenhydramine

Front 8

1st generation antihistamine that is least sedating

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chlorpheniramine or cyclizine

Front 9

2nd generation antihistamines

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fexofenadine, loratadine, and cetirizine

Front 10

Generation of antihistamine that has the most CNS effects

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first generation due to being more lipid soluble

Front 11

Major indication for H1 receptor antagonist

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use IgE mediated allergic reaction

Front 12

Antihistamine that can be used for anxiety and insomnia and is not addictive

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hydroxyzine (Atarax)

Front 13

H1 antagonist used in motion sickness

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Dimenhydrinate, meclizine, and other 1st generation

Front 14

Most common side effect of 1st generation antihistamines

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sedation

Front 15

Lethal arrhythmias resulting from concurrent therapy with azole fungals (metabolized by CYP3A4) and these antihistamines which inhibit 3A4 iso-enzyme

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terfenadine and astemizole (removed from market)

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H2 blocker that causes the most interactions with other drugs

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cimetidine

Front 17

Clinical use for H2 blockers

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acid reflux disease, duodenal ulcer and PUD

Front 18

Receptors for serotonin (5HT-1) are located

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Mostly in the brain, mediating synaptic inhibition via increased K+ conductance

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5HT-1d agonist used for migraine headaches

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Sumatriptan, naratriptan, rizatriptan

Front 20

Triptan available in parenteral and nasal formuation

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sumatriptan

Front 21

H1 blocker that is also a serotonin antagonist

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cyproheptadine

Front 22

Agents for reduction of postpartum bleeding

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oxytocin, ergonovine and ergotamine

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Agents used in treatment of carcinoid tumor

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ketanserin, crproheptadine, phenoxybenzamine

Front 24

5HT-3 antagonist used in chemotherapeutic induced emesis

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ondansetron, granisetron, dolasetron and alosetron

Front 25

5-HT3 antagonist that has been associated with QRS and QTc prolongation and should not be used in patients with heart disease

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Dolasetron

Front 26

DOC to treat chemo-induced nausea and vomiting

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Odansetron

Front 27

Drug used in ergot alkaloid OD, ischemia, and gangrene

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Nitroprusside

Front 28

Reason ergot alkaloids are contraindicated in pregnancy

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Uterine contractions

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SE of ergot alkaloids

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hallucinations resembling psychosis

Front 30

Ergot alkaloid used as an illicit drug

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LSD

Front 31

Dopamine agonist used in hyperprolactinemia

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Bromocriptine