One Liners- Drugs Used In Parkinson's And Other Movement Disorders

Front 1

antipsychotics, reserpine at high doses, and MPTP (product of illicit meperidine analog) and is irreversible

Back 1

drug induced parkinsonism

Front 2

Agent used in drug therapy of Parkinson's instead of one which has low bioavailability and does not cross the BBB

Back 2

L-dopa

Front 3

This combined with L-dopa, inhibits DOPA decarboxylase (active only peripherally) which allows lower effective doses of L-dopa and allows for fewer SE's (GI distress, postural hypotension, and dyskinesias)

Back 3

carbidopa

Front 4

clinical response that may fluctuate in tx of parkinson's dx

Back 4

"on-off-phenomenon"

Front 5

anti-parkinson's drug which increases IOP and is contraindicated in closed angle glaucoma

Back 5

Levodopa

Front 6

ergot alkaloid that is a partial agonist at D2 receptors in the brain, used for patients who are refractory or cannot tolerate levodopa, causes erythromelalgia

Back 6

bromocriptine

Front 7

non ergot agents used as first-line therapy in initial management of Parkinson's

Back 7

pramipexol and ropinirole

Front 8

enhances dopaminergic neurotransmission SE's including CNS excitation, acute toxic psychosis and livdeo reticularis

Back 8

amantadine

Front 9

inhibitor of MAO type B which metabolizes dopamine, used adjunct to levodopa or as sole agent in newly diagnosed pts

Back 9

selegiline

Front 10

inhibitors of catechol-O-methyltransferase (COMT), used as adjuncts in Parkinson's disease and cause acute hepatic failure (monitor LFTs)

Back 10

entacapone and tolcapone

Front 11

agent decreases the excitatory actions of cholinergic neurons- may improve tremor and rigidity but have LITTLE effect on bradykinesia- atropine-like side effects

Back 11

benztropine

Front 12

agent effective in physiologic and essential tremor

Back 12

propanolol

Front 13

agents used in Huntington's Disease

Back 13

tetrabenzamine (amine depleting drug), haloperidol (antipsychotic)

Front 14

agents used in Tourette's

Back 14

Haloperidol or pimozide

Front 15

chelating agent used in Wilson's disease

Back 15

penicillamine