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19 Cards in this Set
- Front
- Back
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What 3 types of cells are targets for anti-cancer agents?
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- tumor
- vascular endothelial - stromal |
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What are 3 ways to assess the anti-tumor activity of a drug?
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- tumor shrinkage (partial vs. complete)
- time to progression/relapse - survival |
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What are 3 anti-metabolites?
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- Methotrexate
- 5-fluorouracil - Gemcitabine |
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What are 4 topoisomerase inhibitors?
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- Etoposide
- Doxorubicin (Adriamycin) - Topotecan - Irinotecan |
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What are 2 alkylating agents?
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- Platinum
- Dacarbzine |
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What are 2 types of anti-tubulin agents?
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- Vinca alkyloids
- Taxols |
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5-fluorouracil is ___-phase specific agent and used for ___, ___, ___, ___, ___, and ___ cancers.
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S-phase
- colon* - breast - rectal - head & neck - cervix |
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Toxicities of 5-FU include:
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- palmar plantar erythema
- photosensitivity - mucositis - hyperpigmentation - diarrhea |
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Methotrexate is ___-phase specific agent and used for ___, ___, ___, ___, and ___ cancers.
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S-phase
- osteosarcoma - lymphoma - breast cancer - leptomeningial disease - childhood ALL |
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Toxicities of MTX are:
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- mucositis
- arachnoiditis - diarrhea - accumulates in 3rd space fluid so don't give if ascites or pleural effusion * Leucovorin rescue |
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Doxorubicin is intercalating agent used for ___, ___, ___, ___, and ___.
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- breast*
- uterine - sarcomas - leukemia - lymphoma |
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Toxicities of Doxorubicin:
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- myelosuppression
- hair loss - CARDIOtoxicity - n/v - radiation recall - hyperpigmentation |
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Cisplatin is ___ agent, used for these 8 cancers:
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alkylating
- testicular - lung - sarcoma - head & neck - cervix - bladder - ovarian |
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Cisplatin's 3 main toxicities are:
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- nephrotoxicity
- ototoxicity (buzzing) - peripheral neuropathy |
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Dacarbazine is alkylating agent used in ___, ___, ___.
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- melanoma
- Hodgkin's - sarcoma |
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Cyclophosphamide is alkylating agent used for ___, ___, ___, ___, and ___.
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- breast
- ovary - lung - bladder - lymphoma |
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Common side effects of cyclophosphamide:
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- hemorrhagic cystitis (must keep hydrated)
- hair loss |
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Taxols are good for ___, ___, ___, ___, ___.
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- breast
- ovary - lung - head & neck |
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Taxols cause patients to get complete _____, nail rot, and peripheral neuropathy.
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complete alopecia!
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