Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/19

Click to flip

19 Cards in this Set

  • Front
  • Back
What 3 types of cells are targets for anti-cancer agents?
- tumor
- vascular endothelial
- stromal
What are 3 ways to assess the anti-tumor activity of a drug?
- tumor shrinkage (partial vs. complete)
- time to progression/relapse
- survival
What are 3 anti-metabolites?
- Methotrexate
- 5-fluorouracil
- Gemcitabine
What are 4 topoisomerase inhibitors?
- Etoposide
- Doxorubicin (Adriamycin)
- Topotecan
- Irinotecan
What are 2 alkylating agents?
- Platinum
- Dacarbzine
What are 2 types of anti-tubulin agents?
- Vinca alkyloids
- Taxols
5-fluorouracil is ___-phase specific agent and used for ___, ___, ___, ___, ___, and ___ cancers.
S-phase
- colon*
- breast
- rectal
- head & neck
- cervix
Toxicities of 5-FU include:
- palmar plantar erythema
- photosensitivity
- mucositis
- hyperpigmentation
- diarrhea
Methotrexate is ___-phase specific agent and used for ___, ___, ___, ___, and ___ cancers.
S-phase
- osteosarcoma
- lymphoma
- breast cancer
- leptomeningial disease
- childhood ALL
Toxicities of MTX are:
- mucositis
- arachnoiditis
- diarrhea
- accumulates in 3rd space fluid so don't give if ascites or pleural effusion
* Leucovorin rescue
Doxorubicin is intercalating agent used for ___, ___, ___, ___, and ___.
- breast*
- uterine
- sarcomas
- leukemia
- lymphoma
Toxicities of Doxorubicin:
- myelosuppression
- hair loss
- CARDIOtoxicity
- n/v
- radiation recall
- hyperpigmentation
Cisplatin is ___ agent, used for these 8 cancers:
alkylating
- testicular
- lung
- sarcoma
- head & neck
- cervix
- bladder
- ovarian
Cisplatin's 3 main toxicities are:
- nephrotoxicity
- ototoxicity (buzzing)
- peripheral neuropathy
Dacarbazine is alkylating agent used in ___, ___, ___.
- melanoma
- Hodgkin's
- sarcoma
Cyclophosphamide is alkylating agent used for ___, ___, ___, ___, and ___.
- breast
- ovary
- lung
- bladder
- lymphoma
Common side effects of cyclophosphamide:
- hemorrhagic cystitis (must keep hydrated)
- hair loss
Taxols are good for ___, ___, ___, ___, ___.
- breast
- ovary
- lung
- head & neck
Taxols cause patients to get complete _____, nail rot, and peripheral neuropathy.
complete alopecia!