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15 Cards in this Set
- Front
- Back
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Monoclonal Ab
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ok
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Avastin
Target? 1 Primary SE? 5 Other SE? |
Bevacizumab - VEGF-A
GI perforation (fatal) Impaired wound healing, thrombosis, bleeding, nephrotic synd, proteninuria |
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Rituxan
Target? 4 Primary SE? |
Rituximab - CD-20
CD-20 target on lymphocytes; kills CA cell but release cytokines Prior to infusion, admin DPH & APAP Infusion rxn (fatal) TLS Myelosuppression Infxn |
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Erbitux
Target? 4 Primary SE? |
Cetuximab - EGFR-A
EGFR expression - good response K-ras mutation - poor response Prior to infusion, admin DPH Infusion rxn, cardiopulmonary arrest, Mg/Ca wasting, acne-like rash (1st few weeks of tx) |
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Herceptin
Target? 1 Toxicity? 2 Primary SE? |
Trastuzumab - HER2/neu
HER2/neu overexpression req for use Prior to infusion, admin H1-blocker Pulmonary Toxicity Cardiomyopathy (avoid use w/ athracyclines), Allergic Infusion runs N/V/D, joint pain |
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Tyrosine Kinase INH (TKI)
Class DI |
Significant DI w/ 3A4 INH
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Xalkori
Target? Dose? 3 Primary SEs? DI? Test? |
Crizotinib
ALK - regulate growth in NSLC (prevalent in non-smokers/light smokers) PO BID w/o regard to food Test if ALK positive - req Vision disturbances Constipation Pneumonitis |
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Bosulif
Target? Dose? Test? Primary SE? |
Bosutinib - BCR-ABL TKI
WC - PO QD Test if BCR-ABL positive - req DIarrhea |
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Sprycel
Target? Test? |
Dasatinib - BCR-ABL TKI
Test if BCR-ABL positive - req Pleural effusion |
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Gleevec
Dose? Target? Test? 4 Primary SE? |
Imatinib - BCR-ABL TKI
WC + Water - PO Test if BCR-ABL positive - req Ph+ CML or cKIT (CD117)-positive stromal tumors (GIST) Fluid retention CHF Skin Rashes Leukopenia, thrombocytopenia |
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Tasigna
Dose? Target? Test? 1 Primary SE? |
Nilotinib - BCR-ABL TKI
Empty stomach - PO BID Test if BCR-ABL positive - req Prolong QT interval |
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Zelboraf
Target? Test? 2 Primary SE? |
Vemurafenib - BRAF TKI
Test if BRAF positive melanoma (not wild type) + V600E mutation - req Dermatologic d/o QT prolongation |
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Tarceva
Target? Dose? 2 Primary SE? |
Erlotonib - EGFR TKI
EGFR target - adenocarcnom NSCLC req PO PC (1H before, 2H after) Diarrhea, acneiform rash |
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Tykerb
Target? Ix? Dose? SE? |
Lapatinib - HER2/neu TKI
Ix: metastatic breast CA (failed trastuzumab/chemo) Empty stomach Dec LVEF, QT prolongation, |
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Jakafi
Target? Substrate? 1 Primary SE? |
Ruxolitinib - JAK1 & JAK2
3A4 substrate Thrombocytopenia (dose-limititing toxicity) Opportunistic Infxns |
