Oncology - Ca Drugs Brand/generic/se

Front 1

Alkylators

MOA

Back 1

Cross link DNA-preventing cell replication

Front 2

Cytoxan

Back 2

Cyclophosphamide

IP - Hemorrhagic cytitis (high dose - Mesna + hydration)

Front 3

Leukeran

Back 3

Chlorambucil

N - Neurotox

Front 4

Temodar

Back 4

Temazolomide

X BBB - used for brain CA

Lomustine PO QHS + antiemetic

Front 5

Thioplex

Back 5

Thiotepa

N- Neurotox

Front 6

Myleran

Back 6

Busulfan

Pulmonary tox, skin pigmentation

Front 7

Ifex

Back 7

Ifosphamide

IP, N - Hemorrhagic cytitis (all doses), Neurotox

Front 8

Matulane

Back 8

Procarbazine

DD, N - cadiotox, neurotox

Front 9

BiCNU, Gliadel

Back 9

Carmustine

BB, N - pulmonary tox, neurotox

Front 10

CeeNu

Back 10

Lomustine

BB, N - pulmonary tox, neurotox

Front 11

REC Blocker - Antiandrogen

- Ix
- Give with?
- SE

Back 11

For Prostate CA

PO with LHRH agonists

Hepatotox, N/V/D, hot flashes, dec libido, gynecomastia, impotence

Front 12

Casodex

Back 12

Bicalutamide

Front 13

Eulexin

Back 13

Flutamide

GI tox

Front 14

Nilandron

Back 14

Nilutamide

Visual disturbance

Front 15

LHRH Agonists - Antiandrogen/antiestrogen

- Ix
- Give with?
- SE

Back 15

Males - Prostate CA, endometriosis, fibriods CA
Females - Breast CA

Start REC Blocker (antiestrogen) then LHRH agonist - red risk of SCC/metastatic bone pain d/t initial surge in LH, FSH, testosterone

QT Prolongation, peripheral edma, bone pain, dec bone density, hot flashes, impotence

Front 16

Zoladex

Back 16

Goserelin

Front 17

Vantos

Back 17

Histerelin

Front 18

Lupron

Route?

Back 18

Leuprolide

IM

Front 19

Eligard

Route?

Back 19

Leuprolide

SC

Front 20

Viadur

Route?

Back 20

Leuprolide

SC

Front 21

Trelstar

Back 21

Triptorelin

Front 22

Aromatese INH - antiandrogen/antiestrogen

Route?
IX
Primary SE
Supplementation?

Back 22

ALL PO

Prostate/adrenal CA

For POST - menopausal women; NOT men

CV risk, dec bone density, menopause sxs, N/V, hot flash

Ca/Vit D (all)
Glucocorticoid/mineralcorticoid (Cytaraden, Femera)

Front 23

Cytareden

Non - selective

Supplementation?

Back 23

Aminoglutethimide

Glucocorticoid/mineralcorticoid (Cytaraden, Femera)

Front 24

Arimidex

Ix

Back 24

Anastrozole

Estrogens - Breast CA

Front 25

Aromasin

Ix

Back 25

Exemestane

Estrogens - Breast CA

Front 26

Femara

Ix

Back 26

Letrozole

Estrogens - Breast CA

Front 27

Lysodren

Non - selective

Supplementation?

Back 27

Mitotane

Glucocorticoid/mineralcorticoid (Cytaraden, Femera)

Front 28

SERMs/Antiestrogen

Route?
Ix?

Back 28

PO (most), IM (Faslodex)

Breast CA in hormone REC + tumors (estrogen/progesterone)

POST-menaupausal women
PRE- & POST - menopausal women & MEN (Nolvadex)

Front 29

Faslodex

Route?

Back 29

Fulvestrant

IM

Front 30

Evista

Other Ix

Back 30

Raloxifene

Osteoperosis in women at r/o Breast CA

Front 31

Nolvadex

Ix?
r/o?

Back 31

Tamoxifen

PRE- & POST - menopausal women & MEN (Nolvadex)

Inc r/o endometrial CA

Front 32

Fareston

Back 32

Toremifene

Front 33

Anthracycline

Back 33

Cartiotoxic
N/V
Red urine and body secretions

Front 34

Cerubidine

Back 34

Daunorubicin

Front 35

DaunoXome

Back 35

Daunorubicin liposomal

Front 36

Adriamycin

Back 36

Doxorubicin

Front 37

Doxil

Back 37

Doxorubicin liposomal

Associated with higher incidence of hand-foot syndrome and allergic reactions

Front 38

Ellence

Back 38

Epirubicin

Front 39

Idamycin

Back 39

Idarubicin

Front 40

Novantrone

Back 40

Mitoxantrone

Anthracenedione - 3 membered ring not 4
Turns body fluids blue rather than red

Front 41

Valstar

Back 41

Valrubicin

Instilled in the bladder refractory CA

Front 42

Totect

Back 42

Dexrazoxane

Also an antidote for extravasation is dimethyl sulfoxide

Front 43

Zinecard

Back 43

Dexrazoxane

used when doxorubicin dose anticipated to cont beyond 300 mg/m2

Front 44

Folate Antimetabolites

Back 44

Prevents DNA synthesis

Front 45

Trexall

Back 45

Methotrexate

Mucositis, hepatotox, renal tox, pulmonary tox, hand-foot synd

High-dose can penetrate BBB; can be used for malignancies (osteocarcinoma).

High-dose require leucovorin rescue; dec MTX fox

Front 46

Mexate

Back 46

Methotrexate

Avoid use: ASA, PCN, NSAIDs, probenacid
d/t dec in renal elimination resulting in toxicity

Front 47

Folex

Back 47

Methotrexate

Maintain hydration and drink fluids

Front 48

Alimta

Back 48

Pemetrexed

Front 49

Folotyn

Back 49

Pralatrexate

Front 50

Immuno-mudulators

Back 50

Dec angiogenesis and kills abnormal cells in bone marrow while helping bone marrow to produce normal healthy cells

MDS and multiple myeloma

Front 51

Revlimid

Back 51

Lenalidomide

Preg X
Neutropenia, thrombocytopenia, DVT/PE

Front 52

Thalomid

Back 52

Thalidomide

Preg X
Neutropenia, thrombocytopenia, DVT/PE

Front 53

Interferons

Back 53

Inhibit growth of tumor, inc tumor antigenicity, down regulate oncogenes, induce differentiation, inhibits angiogenesis and inhibits cell proliferation

Front 54

Interferons-alfa

Peginterferon

Back 54

2a - Roferon
2b - Intron-A

2a - Pegasys
2b - PEG-Intron, Sylatron

Depression, suicidal ideation, flu-like syndrome, alopecia

Front 55

Interferon-beta

Back 55

1a - Avonex
1b - Betaseron

Depression, suicidal ideation, flu-like syndrome

Front 56

Monoclonal Ab

Back 56

ok

Front 57

Avastin

Back 57

Bevacizumab

Binds to VEGF-A

GI perforation (fatal), impaired wound healing, thrombosis, bleeding, nephrotic synd, proteninuria

Front 58

Rituxan

Back 58

Rituximab

CD-20 target on lymphocytes; kills CA cell but release cytokines

Prior to infusion, admin DPH & APAP

Infusion rxn (fatal), TLS, myelosuppression, infxn

Front 59

Erbitux

Back 59

Cetuximab

EGFR expression - good response
K-ras mutation - poor response

Prior to infusion, admin DPH

Infusion rxn, cardiopulmonary arrest, Mg/Ca wasting, acne-like rash (1st few weeks of tx)

Front 60

Herceptin

Back 60

Trastuzumab

HER2/neu overexpression req for use

Prior to infusion, admin H1-blocker

Cardiomyopathy (avoid use w/ athracyclines), Allergic Infusion rxns, Pulmonary Tox, N/V/D, joint pain

Front 61

T-DM1

Back 61

Trastuzumab-DM1

HER2/neu overexpression req for use

Front 62

mTOR INH

Back 62

INH dowstream regulation of VEGF reducing cell drouth, metabolism, proliferation and angiogenesis

Interstitial lung dz
Dylipidemia

Front 63

Afinitor

Back 63

Everolimus

Stomatitis
Rash
Interstitial lung dz
Dylipidemia

Front 64

Torisef

Back 64

Temsirolimus

Myelosuppression
HyperGlycemia
Interstitial lung dz
Dylipidemia

Front 65

Platinum-based Compounds

Back 65

X-links DNA, leading to apoptosis

Neuropathy - dose dependent
Hypersensitivity Rxns - Steroids + AntiHistamines (pretx)
Myelosuppression

Front 66

Paraplatin-AQ

Back 66

Carboplatin

Nephrotox - Mannitol, Amifostine (Ethyol)
Ototox - Audiogram (prior to cycle)
Electrolyte Wasting - Mg/Ca Supplementation
N/V - AntiEmetic (3 drug combo)

Front 67

Eloxatin

GI Malignancy: + 5FU/leucovorin

Back 67

Oxaliplatin

PiLL - Pancreatitis, Pulmonary Tox, Hepatotox
Neuropathy (exacerbated by cold) - Mg/Ca infusion prior red by 50%

Front 68

Purine Analog Antimetabolite

6 - MP

Dose?
SE?
DI?
Test?

Back 68

Mercaptopurine

PO PC (1H before, 2H after)

Hepatotox
Myelosuppression

ALLOPURINOL - INH xanthine oxidase; INC 6-MP bioavailability 400-500%; REQ dose reduction

TPMT deficiency test - prior to tx; avoid toxicity

Front 69

Purinethol

Back 69

Mercaptopurine

Front 70

Pyrimidine Analog Antimetabolite

Back 70

INH pyrimidine synthesis

HAND-FOOT SYND

Front 71

Xeloda

Dose?
SE?
DI?
Test?

Back 71

Capecitabine (prodrug of 5-FU)

PO w/ FOOD

Cardiotox
Hand-foot synd
Mucositis
Myelosupression, dermatitis, diarrhea

WARFARIN - req dec warfarin dose; Xeloda inc INR (91%)

DPD deficiency test - avoid severer toxicity

Front 72

Ara-C

Back 72

Cytarabine

Front 73

Cytosar

Back 73

Cytarabine

Front 74

DepoCyt

Route?

Back 74

Cytarabine

IntraThecal admin

Front 75

5-FU

Given with?

Back 75

Fluorouracil

+ Leucovorin - inc efficacy

DPD deficiency test

Front 76

Adrucil

Back 76

Fluorouracil

Front 77

FUDR

Back 77

Floxuridine

Front 78

Gemzar

Back 78

Gemcitabine

Flu-like synd (during 1st 24H) - APAP for tx

Front 79

Retinoids (Vit A analogues)

Back 79

Dec cell proliferation and promotes apoptosis

Front 80

All-trans Retinoic Acid, Vesanoid

Back 80

Tretinoin

Front 81

Taxanes

Dosed?
SE?

Back 81

Give Taxanes first - then can give Cisplatin/Carboplatin so that taxenes bioavailable

Non-PVC
Hypersensitivity rxns
Myelosuppression
N/V
Alopecia
Arthralgia/Myalgia

Front 82

Jevtana

Back 82

Cabazitaxel

Front 83

Taxotere

Primary SE & pretx?

Di?

Back 83

Docetaxel

Cardio-Pulmonary fluid retention - Decadron 8mg x 3d pretx

INC INR

Front 84

Taxol

Back 84

Paclitaxel

Front 85

Abraxane

Back 85

Paclitaxel albumin-bound

Less Hypersensitivity rxns - Doesn't req pretx

Front 86

Topo INH

Back 86

OK

Front 87

Camptosar

SE?
DI?
Test?

Back 87

Ironotecan

Acute Diarrhea - Atropine
Delayed Diarrhea - Loperamide (up to 24mg QD)

UGT1A1**28 allelle - inc r/o Neutropenia/other tox

N/V, Myellosuppresion, Alopecia, dyspnea, inc LFTs

Front 88

Hycamtin

Back 88

Topotecan

Front 89

VePesid

Tox SE?

Back 89

Etoposide

Req refrigeration

Hepatotox, Neurotox (cummulative), Neuropathy (cummulative)

Myelosuppression, Alopecia, N/V, Mucositis

Front 90

VP-16

Back 90

Etoposide

Front 91

Tyrosine Kinase INH (TKI)

Class DI

Back 91

Significant DI w/ 3A4 INH

Front 92

Xalkori

Target?
Dose?
SE?
DI?
Test?

Back 92

Crizotinib

ALK - regulate growth in NSLC (prevalent in non-smokers/light smokers)

PO BID w/o regard to food

Test if ALK positive - req

Vision disturbances, N/V, edema, Constipation, pneumonitis

Front 93

Bosulif

Back 93

Bosutinib

PO QD w/ food

Test if BCR-ABL positive - req


DIarrhea

Front 94

Sprycel

Back 94

Dasatinib

Test if BCR-ABL positive - req

Pleural effusion

Front 95

Gleevec

Back 95

Imatinib

PO w/ water & food

Test if BCR-ABL positive - req

Ph+ CML or cKIT (CD117)-positive stromal tumors (GIST)

Fluid retention
CHF
Skin Rashes
Leukopenia, thrombocytopenia

Front 96

Tasigna

Back 96

Nilotinib

PO BID Empty stomach

Test if BCR-ABL positive - req

Prolong QT interval

Front 97

Zelboraf

Back 97

Vemurafenib

Test if BRAF positive melanoma (not wild type) + V600E mutation - req

Dermatologic d/o
QT prolongation

Front 98

Tarceva

Target?
Dose?
SE?

Back 98

Erlotonib

EGFR target - adenocarcnom NSCLC req

PO PC (1H before, 2H after)

Diarrhea, acneiform rash

Front 99

Tykerb

Target?
Dose?
Ix?
SE?

Back 99

Lapatinib

Target HER2/neu

Empty stomach

Ix: metastatic breast CA (failed trastuzumab/chemo)

Dec LVEF, QT prolongation,

Front 100

Jakafi

Back 100

Ruxolitinib

Target JAK1 & JAK2

3A4 substrate

Thrombocytopenia

Front 101

Vinka Alkaloids

Route?
SE?

Back 101

INH microtubule function (destabilizers)

IV - central line only; Fatal if intrathecal
VESSICANTS - Hyaluronidase/warm compress tx for extravasation

Primary SE - Peripheral Neuropathy (dose-dependent)

Front 102

Velban

Back 102

Vinblastine

Front 103

Vincasar

Back 103

Vincristine

Max single dose = 2 mg

Alopecia

Front 104

Oncovin

Back 104

Vincristine

Max single dose = 2 mg

Alopecia

Front 105

Marqibo

Back 105

Vincristine liposomal

2.25 mg/m2 QW IV x 1H

Front 106

Navelbine

Back 106

Vinorelbine

Front 107

Blenoxane

Primary SE?
Lifetime dose?

Back 107

Bleomycin

PUlmonary rxns - pneumonitis, pulmonary fibrosis
Hypersensitivity rxns

Max lifetime dose = 400 U

Front 108

Epogen

Back 108

Epoetin alfa

Front 109

Procrit

Back 109

Epoetin alfa

Front 110

Aranesp

Back 110

Darbapoetin

Front 111

Leukine

Back 111

Sargramostim

Front 112

Neupogen

Back 112

Filgastrim

Front 113

Neulesta

Back 113

Pegfilgastrim

Front 114

Zofran

Back 114

Ondansetron

PO, ODT, solution, IV
x1 IV dose = 16 mg

Front 115

Zuplenz film

Back 115

Ondansetron

Front 116

Anzemet

Back 116

Dolasetron

Front 117

Aloxi

Back 117

Palonosetron

Front 118

Compro

Back 118

Prochlorperazine

PO, PR

Front 119

Phenergan

Back 119

Promethazine

IM/IV/PR

Front 120

Phenadoz

Back 120

Promethazine

IM/IV/PR

Front 121

Promethegan

Back 121

Promethazine

IM/IV/PR

Front 122

Decadron

Back 122

Dexamethasone

PO/IV

Front 123

Marinol

Back 123

Dronabinol

CIII

Front 124

Cesamet

Back 124

Nabilone

CII

Front 125

Emend

Back 125

Aprepitant

Front 126

Emend INJ

Back 126

Fosaprepitant

Front 127

Reglan

Back 127

Metoclopramide

Front 128

IL - 11

Back 128

Oprelvekin

Front 129

Neumega

Back 129

Oprelvekin