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42 Cards in this Set
- Front
- Back
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what 4S NB should be treated with chemo
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MYCN amplified
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which renal tumors should have brain imaging
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clear cell sarcoma
rhabdoid MRI |
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inital eval for wilms
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CT chest/ abd
CXR |
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work-up for clear cell sarcoma
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scans
bone marrow aspirate/biopsy skeltal survey bone scan MRI brain |
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distinctions on imaging between diffuse intrinsic pontine glioma and pilocytic astrocytoma
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DIPG: enlarged pons, not enhancing, can engulf the basilar artery
PA: contrast enhancing, pushes pons out of the way, not likely to engulf the basilar artery |
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a diagnosis of diabetes insipitus often precedes the diagnosis of which brain tumor
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germinoma
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treatment for ependymoma
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gross total resection
local RT |
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2 most common locations for germinoma
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suprasellar
pineal |
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2 most common radiation associated brain tumors
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meningiomas
GBM |
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what is the prognosis of a RT induced GBM compared to a de novo GBM
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worse
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imaging description of a GBM
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intraparanchymal
necrotic center contrast enhanciong rim |
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staging for HD
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Ann Arbor
1 - single node region 2 - 2 or more node regions, same side diaphragm 3 - nodes both sides of the diaphragm 4 - diffuse or disseminated |
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If the spleen is involved in HD, what is the stage?
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stage 3
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what is stage 1 NHL
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single nodal or extranodal tumor, EXCLUDING the mediastinum and abdomen
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what is stage 2 NHL
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One of the following:
- single extranodal with regional node involvement - 2 or more nodes or extranodal tumors on the same side of the diaphragm - ** localized (completely or grossly resected) GI disease |
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what is stage 3 NHL
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one of the following:
- two or more extranodal tumors on oppposite sides of the diaphragm - only intrathoracic disease (lung, pleura, mediastinum, thymic -extensive unresectable abdominal disease -paraspinal or epidural disease |
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stage 4 NHL
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BM or CNS +
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Characteristics that confer unfavorable prognosis in HD
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- B symptoms
- stage 4 - bulky disease (> 33% chest diameter measured at diaphragm) |
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which type of lymphoma most commmonly involves the skin
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anaplastic large cell lymphoma
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diagnostic translocation for ALCL
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t2;5 (npm/alk fusion)
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CD markers that differentiate HD from ALCL
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both are CD30 + but HD is CD 45 + and ALCL is CD 45 -
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Li Fraumeni
increased risk for which CA |
adenocortical CA
OS RMS breast brain leukemia |
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risk of CA in NF1
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NF
optic glioma pheo AML |
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risk of CA in NF2
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vestibular schwannoma
central NF meningioma |
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risk of which CA in Gorlin-Goltz
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medulloblastoma
basal cell carcinoma |
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genetic risk in family with POSITIVE family history of
RB: (unilateral OR bilateral disease) - risk for parents to have another child with RB - risk for an AFFECTED patient to have offspring with RB - risk for a NORMAL sibling of the affected patient to have offspring with RB |
- risk for parents to have another child with RB - 40%
- risk for an AFFECTED patient to have offspring with RB - 40% - risk for a NORMAL sibling of the affected patient to have offspring with RB - 7% |
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genetic risk in family with negative family history of
RB and UNILATERAL disease - risk for parents to have another child with RB - risk for an AFFECTED patient to have offspring with RB - risk for a NORMAL sibling of the affected patient to have offspring with RB |
- risk for parents to have another child with RB - 1%
- risk for an AFFECTED patient to have offspring with RB - 8% - risk for a NORMAL sibling of the affected patient to have offspring with RB - 1% |
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genetic risk in family with negative family history of
RB and BILATERAL DISEASE - risk for parents to have another child with RB - risk for an AFFECTED patient to have offspring with RB - risk for a NORMAL sibling of the affected patient to have offspring with RB |
- risk for parents to have another child with RB - 6%
- risk for an AFFECTED patient to have offspring with RB - 40% - risk for a NORMAL sibling of the affected patient to have offspring with RB - 1% |
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where is the RB1 gene
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13q14
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most common second malignancies in RB
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OS
soft tissue sarcomas melanoma |
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where do SMNs most commonly occur in RB
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60% occur in the RT field
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what is trilateral RB
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bilateral RB with intracranial neuroblastic tumor of the pineal gland
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in what forms of RMS should a lymph node biopsy be performed
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paratesticular
extremity |
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in what forms of RMS should CSF cytology be obtained?
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parameningeal
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group system for RMS
group 1: group 2: group 3: group 4: |
group 1: localized disease, completely resected
group 2: gross total resection with evidence of regional spread group 3: INCOMPLETE resection with gross residual disease group 4: distant metastatic disease |
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what sites are considered favorable in RMS:
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orbit
non parameningeal head and neck non bladder/prostate GU biliary tract |
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Staging for RMS (1 to 4)
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Stage 1: favorable site - REGARDLESS of other features
Stage 2: unfavorable site, only small tumors, negative nodes Stage 3: unfavorable site, large tumor AND/OR postive nodes Stage 4: metastatic |
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which RMS patients do not get RT
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group 1 embryonal
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which type of non RMS tumor has the best response to chemotherapy
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synovial sarcoma
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what are patients with Rothmund Thomson syndrome at risk of developing?
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32% develop OS
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what is Rothmund Thomson syndrome
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small stature
skin rash skeletal malformation |
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where is the mutation in Rothmund Thomson syndrome
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mutation in RECQL4 helicase gene
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