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32 Cards in this Set
- Front
- Back
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abl
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CML
(tyrosine kinase) |
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c-myc
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Burkitt's lymphoma
(transcription factor) |
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bcl-2
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Follicular and undifferentiated lymphomas (inhibits apoptosis)
(anti-apoptotic molecule) |
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erb-B2
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Breast, ovarian and gastric carcinomas
(tyrosine kinase) |
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ras
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Colon carcinoma
(GTPase) |
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L-myc
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Lung tumor
(transcription factor) |
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N-myc
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Neuroblastoma
(transcription factor) |
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ret
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MEN types II and III
(tyrosine kinase) |
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c-kit
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Gastrointestinal stromal tumor/GIST
(cytokine receptor) |
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Rb (13q)
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Retinoblastoma
Osteoblastoma blocks G1 --> S phase |
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p53 (17p)
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Most human cancers,
Li-Fraumeni syndrome blocks G1 --> S phase |
|
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BRCA1 (17q)
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Breast and ovarian cancer
DNA repair protein |
|
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BRCA2 (13q)
|
Breast cancer
|
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p16 (9p)
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Melanoma
|
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APC (5q)
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Colorectal cancer
(associated with FAP) |
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WT1 (11p)
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Wilms' tumor
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NF1 (17q)
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Neurofibromatosis type 1
|
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NF2 (22q)
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Neurofibromatosis type 2
|
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DPC (18q)
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Pancreatic cancer
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DCC (18q)
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Colon cancer
|
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PSA
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Prostate-specific antigen
elevated in prostate carcinoma, BPH, prostatis |
|
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Prostatic acid phosphatase
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Prostate carcinoma
|
|
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CEA
|
Carcinoembryonic antigen
~70% of colorectal and pancreatic cancers (also produced by gastric, breast, and thyroid medullary carcinomas) |
|
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a-fetoprotein
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Hepatocellular carcinomas
Yolk sac tumor |
|
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beta-hCG
|
Hydatidiform moles
Choriocarcinomas Gestational trophoblastic tumors |
|
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CA-125
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Ovarian, malignant epithelial tumors
|
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S-100
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Melanoma
Nuerual tumors Astrocytomas |
|
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Alkaline phosphatase
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Metastases to bone
obstructive biliary disease paget's disease of bone |
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Bombesin
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Neuroblastoma
Lung and gastric cancer |
|
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TRAP
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Tartrate-resistant acid phosphatse.
Hairy cell leukemia |
|
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CA-19-9
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Pancreatic adenocarcinoma
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Calcitonin
|
Thyroid medullary carcinoma
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