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34 Cards in this Set

  • Front
  • Back
c-myc oncogene
burkitt's lymphoma
bcl-2 oncogene
follicular and undifferentiated lymphomas (inhibits apoptosis)
erb-B2 oncogene
breast, ovarian, and gastric carcinomas
ras oncogene
colon cancer
L-myc oncogene
lung tumor
N-myc oncogene
ret oncogene
multiple endocrine neoplasia (MEN I and II)
gain of function
tumor supressor gene
loss of function - must loose both alleles
Rb tumor supressor gene
- chrom 13q
- retenoblastoma, osteosarcoma
BRCA1 and 2 tumor supressor gene
- chrom 17q and 13q
- breast and ovarian cancer
p53 tumor supressor gene
- chrom 17p
- most human cancers, li-fraumeni syndrome
APC tumor supressor gene
- chrom 5q
- colorectal cancer
WT1 tumor supressor gene
- chrom 11q
- wilms' tumor
NF1 tumor supressor gene
- chrom 17q
- neurofibromatosis type 1
NF2 tumor supressor gene
- chrom 22q
- neurofibromatosis type 2
DPC tumor supressor gene
- chrom 18q
- pancreatic cancer
DCC tumor supressor gene
- chrom 18q
- colon cancer
Tumor marker
- not 1o tool for diagnosis
- can confirm diagnosis, or monitor recurrance and response to therapy
PSA tumor marker
- prostate specific antigen
- prostatic carcinoma
- used for screening
CEA tumor marker
- carcinomembryonic antigen
- nonspecific, produced by 70% of colorectal and pancreatic cancers
- gastric and breast too
alpha-fetoprotein tumor marker
- normally made by fetus
- hepatocellular carcinomas
- nonseminomatous germ cell cancer of the testis
beta-hCG tumor marker
- hydatidiform moles
- choriocarcinomas
- gestational trophoblastic tumors
CA-125 tumor marker
- ovarian
- maligant epithelial tumors
S-100 tumor marker
- melanoma
- nerual tumors
- astrocytomas
alkaline phosphate tumor marker
- metastases to bone
- obstructive bilary disease
- paget's disease of bone
bombesin tumor marker
- neuroblastoma
- lung and gastric cancer
TRAP tumor marker
- tartrate-resident acid phosphate
- hairy cell leukemia - a beta-cell neoplasm
t(9,22) - philadelphia chromosome
burkitt's lymphoma
follicular lymphoma (bcl-2 activation)
M3 type of AML (responsive to all-trans retinoic acid)
Ewing's sarcoma
mantle cell lymphoma