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45 Cards in this Set
- Front
- Back
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B cells - location
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germinal follicles
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T cells - location
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paracortex, thymus
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histiocytes - location
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sinuses, skin (langerhans cells)
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nodal enlargement in pts <30 - usually (malignant/benign)
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usually benign
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nodal enlargement in pts >30 - usually (malignant/benign)
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usually malignant
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painful lympadenopathy implies (inflammation/malignancy)
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inflammation
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painless lympadenopathy implies (inflammation/malignancy)
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malignancy (metastasis or primary malignant lymphoma)
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left supraclavicular node metastasis
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stomach or pancreatic carcinoma
(Virchow's nodes) |
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hilar nodes metastasis
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lung cancer
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para-aortic node metastasis
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testicular cancer
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follicular hyperplasia - prominent ____ ____
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prominent germinal follicles
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dermatopathic lymphadenitis - melanin pigment in ____.
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macrophages
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cat-scratch disease due to ____ ____.
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Bartonella henselae
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Bartonella henselae
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cat-scratch disease (gram -)
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____ produces mononucleosis-like syndrome with painful cervical lymphadenopathy.
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toxoplasmosis
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Tularemia - reservoir
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rabbits (also rodents, deer)
**hunters! |
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tularemia - MC type?
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ulceroglandular type
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sinus histiocytosis in axillary nodes - (favorable/unfavorable) sign in breast cancer
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favorable
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More than 80% of NHL are of ____ origin.
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B-cell
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2nd MC CA in HIV
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NHL
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extranodal sites for NHL
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stomach (MC)
CNS Peyer's patches |
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MC malignant lymphoma in adults/children
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NHL
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EBV - associated lymphoma
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Burkitt's lymphoma
CNS lymphoma (in AIDS) diffuse large B-cell lymphoma (NHL) |
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lymphoma associated with H. pylori
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malignant lymphoma of stomach (derived from MALT)
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NHL associated with Sjogren's syndrome
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predisposes to salivary gland and GI lymphomas
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NHL associated with Hashimoto's thyroiditis
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predisposes to thyroid malignant lymphoma
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mycosis fungoides - neoplasm of which cells?
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CD4 Th cells (skin involvement)
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Common types of B-cell Non-Hodgkin's Lymphoma (5)
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Burkitt's lymphoma
diffuse large B-cell lymphoma extranodal marginal zone lymphoma follicular lymphoma small lymphocytic lymphoma |
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Burkitt's lymphoma - epidemiology
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30% of children with NHL
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Burkitt's lymphoma - clinical findings
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American type - GI tract, para-aortic nodes
African type - jaw (bone marrow involvement, leukemic phase common) |
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"Starry sky" appearance with neoplastic B cells (dark of night) and reactive histiocytes with phagocytic debris (stars)
associated with which NHL? |
Burkitt's lymphoma
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diffuse large B-cell lymphoma - 50% of ____ with NHL.
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50% of adults with NHL
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diffuse large B-cell lymphoma - derives from ____
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germinal center
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diffuse large B-cell lymphoma - clinical findings
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localized disease with extranodal involvement: GI tract, brain (EBV association with AIDS)
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extranodal marginal zone lymphoma - associated with ____ gastritis.
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H. pylori
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extranodal marginal zone lymphoma - derived from?
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MALT
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extranodal marginal zone lymphoma - clinical findings
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low-grade malignant lymphoma of the stomach
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follicular lymphoma - 40% of ____ with NHL
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40% of adults with NHL
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Which B-cell NHL derives from germinal center t(14;18) causing overexpression of BCL2 antiapoptosis gene?
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follicular lymphoma
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small lymphocyctic lymphoma - patients are usually what age?
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>60
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____ syndrome - mycosis fungoides in leukemic phase
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Sézary syndrome
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Nodular sclerosing HL is ____ dominant
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female
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What virus is associated with mixed cellularity HL?
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EBV
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MC type HL
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Nodular sclerosing HL
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neoplastic cell of HL
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Reed Sternberg (CD15+, CD30+)
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