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7 Cards in this Set

  • Front
  • Back
Non-neoplastic Polyps Morphology
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Hyperplastic Polyps vs. Sessile Serrated Adenoma
Hyperplastic Polyp = benign epithelial proliferation

Sessile Serrated Adenoma = pre-cancerous
HNPCC vs. Lynch syndrome
HNPCC = clinical diagnosis w/ Family Hx & clinical hx

Lynch syndrome = genetic diagnosis w/ mutated MMR
MSI-H tumors Histological Features
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Microsatellite Definition
tandem repeats of simple DNA sequence usually 1-6 bp in length

unstable regions

defect in mismatch repair genes
Microsatellite molecular pathology steps
1. inherited or acquired defect in mismatch repair gene

2. alteration of 2nd allele--via LOH, mutation/methylation

3. accumulation of mutations in genes regulating differentation, growth, apoptosis
Bethesda Guidelines for Clinical Dx HNPCC
<50 years old
colorectal cancer