Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
7 Cards in this Set
- Front
- Back
Non-neoplastic Polyps Morphology
|
jhkjh
|
|
Hyperplastic Polyps vs. Sessile Serrated Adenoma
|
Hyperplastic Polyp = benign epithelial proliferation
Sessile Serrated Adenoma = pre-cancerous |
|
HNPCC vs. Lynch syndrome
|
HNPCC = clinical diagnosis w/ Family Hx & clinical hx
Lynch syndrome = genetic diagnosis w/ mutated MMR |
|
MSI-H tumors Histological Features
|
kjhkj
|
|
Microsatellite Definition
|
tandem repeats of simple DNA sequence usually 1-6 bp in length
unstable regions defect in mismatch repair genes |
|
Microsatellite molecular pathology steps
|
1. inherited or acquired defect in mismatch repair gene
2. alteration of 2nd allele--via LOH, mutation/methylation 3. accumulation of mutations in genes regulating differentation, growth, apoptosis |
|
Bethesda Guidelines for Clinical Dx HNPCC
|
<50 years old
colorectal cancer |