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4 Cards in this Set
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Degeneration of the RPE which may affect vision of patients using quinolones.
• Both medications are antimalarials, which are also commonly used to treat rheumatoid arthritis & lupus erythematosus |
Chloroquine/Hydroxychloroquine
Retinopathy |
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What's the management of Hydroxychloroquine Retinopathy?
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Management:
1. Appropriate monitoring of patients at risk. 2. Prompt discontinuation of medication: - communicate with treating physician (often able to change meds) - patients with mild RPE changes may improve, advanced cases may continue to worsen. OD Monitoring (of pt’s taking hydroxychloroquine) All patients should have a baseline eye exam when quinolone meds first prescribed: 1. Central VF Testing 2. Color Vision Testing |
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What are some signs/symptoms of Hydroxychloroquine Retinopathy?
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• Initial symptom is subtle paracentral scotoma and/or color vision defects
– VA initially normal – may proceed observable fundus changes • Initial sign is loss of foveal reflex and subtle parafoveal RPE stippling • Later a ring of parafoveal RPE atrophy develops – “bulls-eye” maculopathy – VA reduced as this becomes more apparent • Eventually marked atrophy of RPE throughout posterior pole with “choroidal show” and pigment clumping – VA markedly reduced and arterioles attenuated |
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What are some diagnostic methods for Hydroxychloroquine Retinopathy?
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Diagnostic Method
Based on characteristic symptoms/signs in patients taking these meds |
