Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
63 Cards in this Set
- Front
- Back
|
Two heavy chains and two light chains
|
Ig or B cell receptor
|
|
|
Antigen-binding domains of a B cell receptor (BCR)
|
VH: VL
|
|
|
Predominant version of T cell receptor in adaptive immunity
|
alpha and beta receptor
|
|
|
Antigen-binding domains of the T cell receptor (TCR)
|
Valpha: Vbeta
|
|
|
Signaling molecules of BCR complex
|
Ig alpha and Ig beta
|
|
|
Signaling molecules of TCR complex
|
CD3 and zeta
|
|
|
Complexes of peptide: MHC molecules
|
T cell antigen
|
|
|
Proteins, polysaccharides, lipids, nucleic acids, small chemicals
|
B cell antigens
|
|
|
Cells whose antigen receptors that are both membrane bound
and secreted |
BCR/ Immunoglobulins (Ig)
|
|
|
Portion of Ig molecule that binds antigen
|
Fab
|
|
|
Portion of Ig molecule that binds complement
|
Fc
|
|
|
Portion of Ig molecule that binds to macrophages
|
Fc
|
|
|
Number of antigen binding sites on the TCR
|
One
|
|
|
Most abundant antibody in the bloodstream
|
IgG
|
|
|
IgG heavy chain
|
gamma
|
|
|
IgA heavy chain
|
alpha
|
|
|
Pentameric antibody that potently activates complement
|
IgM
|
|
|
IgM heavy chain
|
meiu
|
|
|
Only antibody that crosses the placenta
|
IgG
|
|
|
Major class of antibody directed at helminth infections
|
IgE
|
|
|
IgE heavy chain
|
epsilon
|
|
|
Classes of antibody that serve as BCR on naive B cells
|
IgD and IgM
|
|
|
IgD heavy chain
|
delta
|
|
|
Antibody that activates mast cells
|
IgE
|
|
|
It fxns in cleaving C3
Possible answers: a. C3 convertase Alternative Pathway b. C3 convertase Classic Pathway c. C5 convertase Alternative Pathway d. C5 convertase Classic Pathway e. MAC |
C3 convertase fxns to cleave C3 in the Alternative and Classical Pathways
|
|
|
Two classes of Ig that possess a J chain
|
IgM and sIgA
|
|
|
Half-life of IgG
|
21 days
|
|
|
Derivation of antibodies from a single clone of B lymphocytes
that have identical antigen specificity |
Monoclonal antibody
|
|
|
kappa and ipsilon
|
Ig light chains
|
|
|
Portion of Ig molecule that determines isotype
|
Heavy chains
|
|
|
Activated and differentiated B cell that secretes antibody
|
Plasma cell
|
|
|
Gene segments in variable regions of Ig heavy chain and TCR betta
chain |
V, D, and J
|
|
|
First recombination event in BCR heavy chain and TCR â chain
|
D-J joining
|
|
|
Ig light chain and TCR alpha chain gene segments in variable
regions |
V and J
|
|
|
Rearrangement of V, D, and J segments
|
Somatic recombination
|
|
|
Process that ensures expression of BCR with single specificity
|
Allelic exclusion
|
|
|
Change of Ig class but preservation of antigen specificity
|
Isotype switching
|
|
|
Nucleotide changes in variable regions of Ig genes affecting
affinity for antigen |
Somatic hypermutation
|
|
|
Enzymes responsible for somatic recombination
|
VDJ recombinase (RAG-1
and RAG-2) |
|
|
Number of CDRs in an intact TCR
|
Six
|
|
|
Total number of V-(D)-J combinations
|
Combinatorial diversity
|
|
|
Number of CDRs in an intact BCR
|
Six
|
|
|
Stage of B cell with no detectable recombination events
|
Pro-B cell
|
|
|
Stage of B cell with recombined H chain and mieu RNA and
surrogate light chains |
Pre-B cell
|
|
|
Stage of B cell with IgM expressed on surface
|
Immature B cell
|
|
|
Stage of B cell with IgM and IgD expressed on surface
|
Mature B cell
|
|
|
Stage of T cell with no recombined beta chain
|
Double negative thymocyte;
Pro-T cell |
|
|
Stage of T cell with recombined beta chain and expressed pre-Talpha
|
Pre-T cell
|
|
|
Stage of T cell with expressed TCR and both CD4 and CD8
|
Double-positive T cell;
immature T cell |
|
|
Weak recognition of MHC Class II + self-peptide
|
Positive selection for CD4+
|
|
|
Weak recognition of MHC Class I + self-peptide
|
Positive selection for CD8+
|
|
|
No recognition of MHC + self-peptide
|
Failure of positive selection
|
|
|
Strong recognition of MHC + peptide
|
Negative selection
|
|
|
Which for of IgG reconizes carbohydrates?
|
IgG4
|
|
|
Which IgG types reconize protine?
|
IgG 1 2 and 3
|
|
|
What is the serum half-life for a IgG antibody?
|
23 days
|
|
|
Which classes of Ab form complexes with other Abs
|
IgA and IgM
|
|
|
Whcih IgA for is most abundand?
|
IgA 1
|
|
|
Mucosal Ab?
|
IgA
|
|
|
Ab involved in clearance and neutralization?
|
IgA
|
|
|
Monoclonal Ab?
|
An Ab that reconizes only one type of Ab.
|
|
|
Hybridoma?
|
a spleen B cell that is fused with a myeloma cell creating and inmortalized B plasma cell.
|
|
|
Humanized Ab?
|
When mouse reconition sequence is grafted onto human Fc
|
