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27 Cards in this Set

  • Front
  • Back
Which of the following is a common cause of hirsutism and virilization?
Polycystic ovarian disorder
Hirsutism and virilization are characterized as
androgen-excess disorders
Which of the following is a major function of androgens in women?
Precursor for estrogen biosynthesis
The treatment for androgen-excess disorders is directed at
suppression of source of androgen
What histologic structure is characteristic of teh hilus cell tumor?
Reinke crystalloid
Hirsutism is most frequently associated with
development of acne
Which is the first event usually associated with virilization?
Enlargement of the clitoris
In adipose tissue, there is extraglandular production of testosterone from
androstenedione
In hair follicles, dihydrotestosterone is produced by the local action of 5-alpha-reductase on
testosterone
What percent of testosterone is not bound to sex hormone-binding globulin (SHBG)?
1 to 3%
The hepatic production of sex hormon-binding globulin is stimulated by
estrogen
In women, the most common cause of hirsutism associated with androgen excess is
polycystic ovarian disease
Which of the following is inconsistent with the diagnosis of polycystic ovarian disease?
Virilization
Which of the following is a characteristic finding in women with polycystic ovarian disease?
Androstenedione at the upper limits of normal or increased
Successful treatment of polycystic ovarian syndrome with oral contraceptives should result in
decreased ovarian androgen secretion
An example of virilization caused by polycystic ovarian syndrome is
acanthosis nigricans
Sertoli-Leydig cell tumors are characterized by increased
testosterone secretion
Patients with Sertoli-Leydig cell tumors typically have
an elevated level of testosterone
The surgical removal of a unilateral Sertoli-Leydig cell tumor should result in the reveral of which symptom?
Amenorrhea
Which of the following is characteristic of gynandroblastoma?
Granulosa cell and arrhenoblastoma components
Which of the following is characteristic of lipid (lipoid) cell tumors?
Small tumor containing sheets of round, clear, pale staining cells
Which of the following is most likely to be positively affected following medical treatment of adrenal hyperplasia with prednisone?
Ovulation
Which of the following is characteristic of 11 beta-hydroxylas deficiency?
Increased serum desoxycorticosterone
Women with constitutional hirsutism are characterized by
greater activity of 5-alpha-reductase
The potent metabolite of testosterone that is produced in genital skin and hair follicles is
dihydrotestosterone DHT
Which of the following is associated with hirsutism?
Excess body hair
An elevated 24-hour-free cortisol level is suggestive of what condition?
Cushing disease