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182 Cards in this Set

  • Front
  • Back
The goal of _____ is to provide oxygen to tissues and remove carbon dioxide.
Respiration
In the _____ the air is warmed, humidified, and filtered.
Nose
In the nose, air is warmed by extensive surfaces of the _____ and _____ to within ___° of body temperature.
Conchae; Septum; 1
In the nose, air is humidified to within ___-___% full saturation of water vapor.
2-3
Air filtration in the nose:
1. Large _____ at the entrance to nose remove particles
2. _____ precipitation at conchae (_____)
3. Smallest particles are entrapped by alveolar _____
Hairs; Turbulent; Turbinates; Macrophages
List the structures of the pulmonary anatomy from large to small diameter.
Trachea, Bronchi, Bronchioles, Terminal bronchioles, Respiratory
bronchioles, Alveolar ducts, Alveolar sacs
What is the type of these respiratory cells?
Pseudostratified ciliated columnar (in bronchi)
Simple ciliated columnar becoming cuboidal (in bronchiole)
Epithelial
Respiratory epithelium:
Pseudostratified ciliated columnar (in _____)
Simple ciliated columnar becoming cuboidal (in _____)
Bronchi; Bronchiole
Which respiratory cells beat toward the pharynx to remove particles?
Epithelial
The _____ _____ cells are respiratory epithelial cells that trap particles.
Mucus goblet
Which respiratory cells are curved and make up 5/6 of the anterior portion?

(fraction decreases at lower sections of the airway)
Cartilage
_____ respiratory cells prevent collapse and keep the airway open.
Cartilage
_____ ____ respiratory cells make up the wall in all areas not occupied by cartilage.
Smooth muscle
_____ _____ respiratory cells control the size of the opening of the airway.
Smooth muscle
_____ _____ alveolar cells are simple squamous and allow gas exchange with the blood.
Capillary endothelial
_____ _____ cells are simple squamous; Type I (90% surface area) that allow gas exchange, and Type II (10% surface area) that produce surfactant.
Alveolar epithelial
Alveolar epithelial cells are _____ _____; Type ___ (90% surface area) that allow gas exchange, and Type ___ (10% surface area) that produce surfactant.
Simple squamous;I ; II
_____ are alveolar connective tissue cells that support.
Fibroblasts
Alveolar _____ ingest small particles.
Macrophages
Alveolar _____ cells secrete histamine and slow reacting substance of anaphylaxis (leukotrienes) and cause bronchial constriction (and congestion).
MAST
What respiratory nerve supply has these characteristics?
NT: Epinephrine & norepinephrine
Receptor: Beta adrenergic
Function: Dilates bronchial tree
Sympathetic
What respiratory nerve supply has these characteristics?
NT: Acetylcholine
Receptor: Lung parenchyma
Function: Constricts bronchioles
Parasympathetic
Pulmonary ventilation components:
1. _____ that cause lung expansion and contraction
2. Movement of air in and out of the _____
3. Effect of the thoracic cage on lung _____.
Muscles; Lungs; Expansibility
_____ Law: P1V1=P2V2
If pressure increases, the volume decreases
If pressure decreases, the volume increases
Boyle's
Inspiration:
_____ of diaphragm
Action: _____ movement (energy dependent)
Effect: _____ chest cavity
Contraction; Downward; Lengthens
Expiration:
_____ of diaphragm
Effect: _____ chest cavity
Relaxation; Shortens
What are these?
1. External intercostals
2. SCM
3. Scalenes
4. Anterior serratus
Accessory muscles of inspiration
Accessory muscles of inspiration:
Action: _____ of the ribs
Effect: _____ the A-P diameter of chest cavity
Elevation; Increases
What are these?
1. Abdominals
2. Internal intercostals
Accessory muscles of expiration
Accessory muscles of expiration:
Action: _____ rib cage (Abs also compress the abdominal contents _____ against diaphragm)
Effect: _____ chest cavity and _____ A-P diameter
Depress; Upward; Shortens; Decreases
Lung characteristics:
1. _____ structure (like balloon)
2. _____ at the hilum to the mediastinum
3. _____ by a thin layer of pleural fluid
Elastic; Attached; Surrounded
Continual suction of excess fluid by _____ maintains “suction” between lung pleura and parietal pleura
Lymphatics
What is the pressure of the fluid in the thin space between the lung pleura and the chest wall termed?
Pleural pressure
What is the pressure of the air inside the lung alveoli termed?
Alveolar pressure
Which pressure has these characteristics?
Resting:
-5 cm H20
Normal Inspiration:
-7.5 cm H20
Pleural pressure
Which pressure increases lung volume by 500 ml?
Pleural pressure
Which pressure has these characteristics?
Resting:
0 cm H20
Normal Inspiration:
-1 cm H20
Expiration:
+1 cm H20
Alveolar pressure
Which pressure allows 500 ml of air in and out of the lung?
Alveolar pressure
Which pressure is the difference between the alveolar and pleural pressures?
Transpulmonary pressure
Which pressure measures the elastic force of lung called recoil pressure?
Transpulmonary pressure
What is the extent to which the lungs will expand for each unit increase in transpulmonary pressure?
Compliance of the lungs
The compliance of the lungs is the extent to which the lungs will _____ for each unit increase in _____ pressure.
Expand; Transpulmonary
What does this formula describe?
ΔV/ΔP 200 ml/cm H20
(1 cm H20 ~ 0.7 mmHg)
The compliance of the lungs
___ of the compliance of the lungs is from the elastic forces of the lung _____.
1/3; Tissue
___ of the compliance of the lungs is from the elastic forces caused by _____ _____ of the fluid that lines the inside of walls of _____.
2/3; Surface tension; Alveoli

[P = (2 x surface tension)/radius of alveolus]
Surface tension of the fluid that lines the inside of walls of alveoli is _____ by _____.
Reduced; Surfactant
_____ _____ is the attraction of water molecules by each other at the air-water interface and can cause the _____ to collapse.
Surface tension; Alveoli
Surfactant is secreted by Type ___ alveolar cells and is composed of dipalmitoyl-phosphatidylcholine, surfactant _____ and _____ ions.
II; Apoproteins; Calcium
Which type of work is required to expand the lung against the lung and the chest elastic fibers during inspiration?
Compliance or Elastic work
Which type of work is required to overcome the viscosity of the lung and the chest wall structures during inspiration?
Tissue resistance work
Which type of work is required to overcome airway resistance and move air into the lung during inspiration?
Airway resistance work
_____ Law:
_____ = ΔP π r4 / (8 μ l)
_____ = 8 μ l / (π r4)
Poiseuille's; Flow; Resistance
Poiseuille's law describes:
1. Major _____ in upper airways
2. Decrease in lung _____ results in an increase in resistance
Resistance; Volume
In Poiseuille's law formula, what does μ represent?
Gas viscosity
Segmental bronchioles offer _____ resistance than terminal bronchioles do.
More
_____ _____ collapses
the airway and increases resistance.
Forced expiration
How are pulmonary volumes measured?
Spirometry
Pulmonary volume average:
Young adult males is 20-25% _____ than that of women
_____ in large and athletic people
Less; Greater
There are ___ pulmonary volumes and ___ capacities.
4; 4
A pulmonary capacity is _____ than one pulmonary volume.
Greater
What pulmonary volume exists during normal quiet breathing?
Tidal Volume (TV)

~2000 to ~3000 ml
What pulmonary volume exists when the maximum amount of air possible is in the lungs?
Inspiratory Reserve Volume (IRV)

Average male = ~5000 ml

(3000 + 5000 = 8000 ml total)
What pulmonary volume exists when the maximum amount of air possible has been expired from the lungs?
Expiratory Reserve Volume (ERV)

~1000* ml

(2000 - 1000* = 1000 ml total)
What pulmonary volume exists when the minimum amount of air possible is in the lungs?
Residual Volume (RV)

~1000* ml

(2000 - 1000 = 1000* ml total)
Which pulmonary capacity equals tidal volume combined with inspiratory reserve volume?
Inspiratory capacity (TV+IRV)

3000 ml to 6000 ml

(~3000 ml)
Which pulmonary capacity equals expiratory reserve volume combined with residual volume?
Functional residual capacity (ERV+RV)

2000 ml to 0 ml

(~2000 ml)
Which pulmonary capacity equals expiratory reserve volume combined with tidal volume and inspiratory reserve volume?
Vital Capacity (ERV+TV+IRV)

1000 ml to 6000 ml

(~5000ml)
Which pulmonary capacity equals residual volume combined with vital capacity?
Total lung capacity (RV+VC)

0 ml to 6000 ml

(~6000ml)
What is the total amount of new air moved into respiratory passages each minute termed?
Minute respiratory volume

(a timed volume)
Tidal volume x Respiratory rate = _____ _____ _____
Minute respiratory volume

(a timed volume)
What is the rate at which new air reaches the alveoli, alveoli sacs, alveolar ducts and respiratory bronchioles termed?
Alveolar ventilation

(a timed volume)
(Tidal volume dead space) x respiratory rate = _____ _____
Alveolar ventilation

(a timed volume)
What is air that fills the respiratory passage but where gas exchange does not occur termed?
Dead space
What is the total amount of new air moved into respiratory passages each minute termed?
Minute respiratory volume

(a timed volume)
Tidal volume x Respiratory rate = _____ _____ _____
Minute respiratory volume

(a timed volume)
What is the rate at which new air reaches the alveoli, alveoli sacs, alveolar ducts and respiratory bronchioles termed?
Alveolar ventilation

(a timed volume)
(Tidal volume dead space) x respiratory rate = _____ _____
Alveolar ventilation

(a timed volume)
What is air that fills the respiratory passage but where gas exchange does not occur termed?
Dead space
The volume of _____ dead space is 150ml.
Anatomical
The volume of _____ dead space depends on the ventilation-perfusion ratio.
Physiological
Pulmonary _____:
From right ventricle
Thin walled
Distensible
Short vessels
Large compliance
Deoxygenated blood
Artery
Pulmonary _____:
Empties into left atria
Short
Oxygenated blood
Vein
Blood supply to the supporting lung tissue is from the _____ circulation (1-2%).
Systemic
Pulmonary _____:
1. Drain into the right thoracic duct
2. Prevent pulmonary edema
Lymphatics
_____ _____ pressures (mmHg):
Systolic: 25
Diastolic: 8
Mean: 15
Pulmonary artery
_____ _____ pressures (mmHg):
Systolic: 25
Diastolic: 0 to 1
Right ventricle
The _____ pressure mean is 7 mmHg.
Capillary
The _____ _____ pressure is 2 to 5 mmHg.
Left atria or
Pulmonary vein
The total blood volume of the _____ is 450 ml; 9% of total blood volume.
Lungs
Pulmonary _____ hold 70 ml of blood.
Capillaries
Pulmonary _____ can act as blood reservoirs. Their volume varies from ___ normal volume to ___x normal volume.
Capillaries; ½; 2
When O2 in alveoli decreases below normal (<73 mm Hg P02) the adjacent blood vessels _____.
Constrict

(Opposite of systemic circulation)
Low O2 concentration in alveoli triggers the release of an undiscovered _____ substance that shunts blood to where it will be _____.
Vasoconstrictor; Aerated
While standing, in the _____ _____ portion of lung, Pulmonary arterial pressure (PAP) - 15 mmHg.

(25-15 = 10)
Upper most
While standing, in the _____ _____ portion of lung, Pulmonary arterial pressure (PAP) is normal; 25 mmHg.
Heart level
While standing, in the _____ _____ portion of lung, Pulmonary arterial pressure (PAP) + 8 mmHg.

(25 + 8 = 33)
Lower most
Capillaries remain _____ when Pulmonary arterial pressure (PAP) > Alveolar pressure.
Open
Capillaries remain _____ when Pulmonary arterial pressure (PAP) < Alveolar pressure.
Closed
In zone 1 of the lung there is _____ blood flow during all portions of the cardiac cycle.
No
Characteristics of lung zone 2:
1. _____ blood flow
2. Blood flow only during _____
3. Normal in _____ of lung when standing
4. Occurs about 10 cm above _____ _____ heart to top of lung.
Intermediate; Systole; Apices; Mid level
If blood flow exists in zone 1 of the lung, it is usually a _____ condition.
Pathological
In zone 3 of the lung, there is _____ blood flow during all phases of the cardiac cycle.
Continuous
Zone 3 lung is normal in:
1. _____ lung when standing
2. _____ lung when lying down
3. _____
Lower; Entire; Exercise
What increases pulmonary blood flow by 4-7 times normal and increases pulmonary arterial pressure?
Exercise

(Recruitment and Distension)
Exercise increases pulmonary blood flow by:
1. _____: Increases number of open capillaries
2. _____: Distends all capillaries which increases the rate of flow
Recruitment; Distension
Pulmonary _____ pressure:
Hydrostatic
+7 mm Hg
Colloidal osmotic
-28 mm Hg
Capillary
Time blood stays in pulmonary _____:
Normal Cardiac output
0.8 sec
Increased Cardiac output
0.3 sec
Capillaries
Capillary net filtration pressure:
Outward forces (mmHg):
1. Pulmonary _____ pressure = 7
2. Interstitial _____ pressure = 14
3. _____ interstitial pressure = 8
(Total = 29)
Capillary; Osmotic; Negative
Capillary net filtration pressure:
Inward Force:
1. _____ _____ pressure = 28 mmHg
Plasma osmotic
Negative interstitial pressure keeps alveoli _____.
Dry
_____ _____ of gas is in one direction and moves from an area of high to low concentration.
Net diffusion
_____ gas characteristics:
Percentage: 21%
Diffusion coefficient: 1.0
Partial pressure: 160 mmHg
Oxygen (O2)
_____ gas characteristics:
Percentage: 79%
Diffusion coefficient: .53
Partial pressure: 600 mmHg
Nitrogen (N2)
_____ gas characteristics:
Percentage: 0.03%
Diffusion coefficient: 20.3
Partial pressure: 760 mmHg
Carbon dioxide (CO2)
Gas contributes to total pressure in direct proportion to _____.
Concentration
Carbon dioxide is ___ times more soluble than oxygen.
20
What is the partial pressure that water molecules exert to escape through the membrane termed?
Vapor pressure
At 37° C, _____ _____ of water = 47 mmHg.
Vapor pressure
By the time that air reaches the lung it is fully _____.
Humidified
What does this formula describe?
Pn[sub2]=(760-47) * 0.79=713*0.79=563
Composition of alveolar air
Due to functional residual capacity only 350 ml of new air is brought into the _____ with each normal respiration.
Alveoli
In the process of alveolar ventilation, expired air has alveolar and _____ _____ air.
Dead space
Alveolar partial pressure of oxygen (mmHg) _____ as alveolar ventilation (L/min)increases.
Increases
Alveolar partial pressure of carbon dioxide (mmHg) _____ as alveolar ventilation (L/min)increases.
Decreases
Normal alveolar partial pressure of _____ is 104 mmHg.
Oxygen (O2)
Normal alveolar partial pressure of _____ is 40 mmHg.
Carbon Dioxide (CO2)
What is comprised by these structures?
1. Respiratory bronchiole
2. Alveolar duct
3. Atria
4. Alveolar sacs
Respiratory unit
Oxygen and carbon dioxide diffuse across the respiratory _____.
Membrane
_____ _____ is affected by:
1. Thickness of membrane
2. Area of membrane
3. Diffusion coefficient
4. Partial Pressure of gas
Diffusion capacity
_____ diffusion capacity is:
21 ml/min/mmHg x gradient of 11 mmHg
Oxygen
_____ diffuses across the respiratory membrane at the rate of 230 ml/min.
Oxygen
Pulmonary capillary length % _____ with increased partial pressure of oxygen diffused in the blood.
Increases
_____ diffusion capacity:
400 ml/min/mm Hg * gradient < 1 mmHg
Carbon Dioxide
_____ diffuses across the respiratory membrane at the rate of 200 ml/min.
Carbon dioxide
Pulmonary capillary length % _____ with increased partial pressure of carbon dioxide diffused in the blood.
Decreases
Partial pressure of oxygen diffused in the blood (diffusing capacity) _____ with time spent in the capillary and _____.
Increases; Exercise
Partial pressure of oxygen diffused in the tissue _____ with blood flow.
Increases
_____ _____ has PO2 of 90-95 mmHg
_____ has a PO2 of 30-40 mmHg
Arterial blood; Tissue
_____ PO2 is determined by balance of delivery and usage.
Tissue
Pulmonary capillary length _____ with increased partial pressure of carbon dioxide diffused in the blood.
Decreases
Blood flow _____ with increased partial pressure of carbon dioxide diffused in the tissue.
Decreases
Dissolved _____ solubility is 0.003 ml _____/100 ml blood mmHg
Oxygen; O2
Dissolved _____ solubility in normal blood is 0.3 ml _____ / 100 ml blood
Oxygen; O2
_____ oxygen consumption is 250 ml O2/min and would require 83 L/min blood flow.
Normal
How is 97% of oxygen is transported?
Hemoglobin

(O2 + HB <--> HBO2)
Hemoglobin (Hb) saturation _____ with increased partial pressure of oxygen in the blood and _____ pH.
Increases; Increased
What do these conditions cause?
Decreased pH
­Increased PpCO2
­Increased Temp
­Increased 2-3 DPG
Right shift of oxygen dissociation curve
Right shift of oxygen dissociation curve reflects an _____ partial pressure of oxygen required to achieve the same percent saturation.
Increased
What do these conditions cause?
Increased pH
­Decreased PpCO2
­Decreased Temp
­Decreased 2-3 DPG
Left shift of oxygen dissociation curve
Left shift of oxygen dissociation curve reflects an _____ partial pressure of oxygen required to achieve the same percent saturation.
Decreased
Effects of _____ _____of the dissociation curve at tissue:
1. Increased carbon dioxide in blood
2. Decreased affinity for oxygen
3. Maintainance of partial pressure gradient
Right shift
Effects of _____ _____ of the dissociation curve at lungs:
1. Loss of carbon dioxide at lungs
2. Increased affinity of oxygen
Left Shift
Dissolved _____:
Solubility: 20X oxygen
Venous blood: 2.7 ml/100 ml blood
Arterial blood: 2.4 ml/100 ml blood
Transported: 0.3 ml/100 ml blood
7% total
Carbon dioxide (CO2)
23% of total _____ is bound to hemoglobin.
Carbon dioxide (CO2)
70% of total _____ is in the form of bicarbonate.
Carbon dioxide (CO2)
Right and left shifts of the oxygen dissociation curve are also known as _____ effects.
Bohr
_____ _____ moves carbon dioxide from the cell into hemoglobin (Hb) and from the blood into bicarbonate.
Carbonic anhydrase
Carbonic anhydrase helps to buffer the _____ to 7.3.
pH
What is the effect where binding of oxygen with hemoglobin tends to displace carbon dioxide from the blood termed?
Haldane effect
_____ is a stronger acid, so binding of oxygen with it tends to displace carbon dioxide from the blood.
Hemoglobin

(Haldane effect)
What is the ratio of the rate of carbon dioxide output divided by the rate of oxygen uptake termed?
Respiratory exchange ratio
The _____ _____ ratio for:
Carbohydrates = 1.0
Fats = 0.7
Mixed diet = 0.825
Respiratory exchange
Respiration regulation:
1. _____ gather information
2. The _____ _____ integrates signals
3. _____ are muscles
Sensors; Central controller; Effectors
What is located bilaterally in the medulla oblongata and pons?
Respiratory center
Respiratory center organization:
1. _____ respiratory group
2. _____ respiratory group
3. _____ center
Dorsal; Ventral; Pneumotaxic
Dorsal respiratory group:
A. Location: dorsal part of _____
1. _____ _____ nucleus
2. Sensory from CN ___ & ___
B. Input from:
1. _____receptors
2. _____receptors
3. _____ receptors
C. Function: _____
Medulla; Solitary tract; IX; X; Chemoreceptors; Baroreceptors; Lung; Inspiration (via inspiratory “ramp”)
Ventral respiratory group.
A. Location: _____
1. Anterior and lateral to _____ respiratory group
2. Nucleus _____; retro_____
C. Function: extra respiratory _____
(_____ in normal quiet breathing)
Medulla; Dorsal; Ambiguous; Retroambiguous; Drive; Inactive
Pneumotaxic Center:
A. Location: _____ upper _____
1. Nucleus _____
B. Function: _____ inspiration
1. _____ rate
2. Controls _____ _____ point
Dorsal; Pons; Parabrachialis; Limits; Increases; Switch off
Which lung receptors?
1. Inhibit inhalation
2. Hering-Breuer reflex
Stretch receptors
Which lung receptors?
1. Bronchoconstriction
2. Increased ventilation
Irritant receptors
Which lung receptors?
1. Alveolar wall
2. Lung disease and edema
J receptors
What is this looping sequence?
Inspiratory center -> Phrenic nerve -> Diaphragm contracts -> Stretch receptor -> Vagus nerve --| (-) Inspiratory center
Hering-Breuer reflex
Stretch receptors are located in the _____ portion of walls of _____ and _____.
Muscular; Bronchi; Bronchioles
Stretch receptors prevent excess lung _____ by switching off the _____ respiratory group of the respiratory center.
Inflation; Dorsal
Excess carbon dioxide or excess hydrogen ions in blood greatly _____ the strength of the inspiratory and expiratory centers.
Increase
Excess _____ _____ or excess _____ ions in blood greatly increases the strength of the inspiratory and expiratory centers
Carbon dioxide; Hydrogen
_____ body - _____ of the _____:
1. Responds to oxygen (greatest Po2<100 mmHg)
2. Responds to carbon dioxide and hydrogen ions
Carotid; Bifurcation; Carotids
Changes in arterial PCO2 have _____ effect on control of respiration than changes in arterial pH.
Greater
There is a linear _____ in ventilation with increasing oxygen consumption.
Increase
Arterial PO2, PCO2 and pH do not change in direct correlation to increased _____. PCO2 may _____ slightly.
Ventilation; Decrease
What are these factors thought to be caused by?
1. Overflow of signals from cortex
2. Body movements
3. Increased body temperature
4. Designed to control PCO2
5. Learned response
Respiration during exercise
The exact mechanism responsible for increased _____ is not known.
Ventilation