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182 Cards in this Set
- Front
- Back
The goal of _____ is to provide oxygen to tissues and remove carbon dioxide.
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Respiration
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In the _____ the air is warmed, humidified, and filtered.
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Nose
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In the nose, air is warmed by extensive surfaces of the _____ and _____ to within ___° of body temperature.
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Conchae; Septum; 1
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In the nose, air is humidified to within ___-___% full saturation of water vapor.
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2-3
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Air filtration in the nose:
1. Large _____ at the entrance to nose remove particles 2. _____ precipitation at conchae (_____) 3. Smallest particles are entrapped by alveolar _____ |
Hairs; Turbulent; Turbinates; Macrophages
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List the structures of the pulmonary anatomy from large to small diameter.
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Trachea, Bronchi, Bronchioles, Terminal bronchioles, Respiratory
bronchioles, Alveolar ducts, Alveolar sacs |
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What is the type of these respiratory cells?
Pseudostratified ciliated columnar (in bronchi) Simple ciliated columnar becoming cuboidal (in bronchiole) |
Epithelial
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Respiratory epithelium:
Pseudostratified ciliated columnar (in _____) Simple ciliated columnar becoming cuboidal (in _____) |
Bronchi; Bronchiole
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Which respiratory cells beat toward the pharynx to remove particles?
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Epithelial
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The _____ _____ cells are respiratory epithelial cells that trap particles.
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Mucus goblet
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Which respiratory cells are curved and make up 5/6 of the anterior portion?
(fraction decreases at lower sections of the airway) |
Cartilage
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_____ respiratory cells prevent collapse and keep the airway open.
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Cartilage
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_____ ____ respiratory cells make up the wall in all areas not occupied by cartilage.
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Smooth muscle
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_____ _____ respiratory cells control the size of the opening of the airway.
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Smooth muscle
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_____ _____ alveolar cells are simple squamous and allow gas exchange with the blood.
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Capillary endothelial
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_____ _____ cells are simple squamous; Type I (90% surface area) that allow gas exchange, and Type II (10% surface area) that produce surfactant.
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Alveolar epithelial
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Alveolar epithelial cells are _____ _____; Type ___ (90% surface area) that allow gas exchange, and Type ___ (10% surface area) that produce surfactant.
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Simple squamous;I ; II
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_____ are alveolar connective tissue cells that support.
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Fibroblasts
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Alveolar _____ ingest small particles.
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Macrophages
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Alveolar _____ cells secrete histamine and slow reacting substance of anaphylaxis (leukotrienes) and cause bronchial constriction (and congestion).
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MAST
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What respiratory nerve supply has these characteristics?
NT: Epinephrine & norepinephrine Receptor: Beta adrenergic Function: Dilates bronchial tree |
Sympathetic
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What respiratory nerve supply has these characteristics?
NT: Acetylcholine Receptor: Lung parenchyma Function: Constricts bronchioles |
Parasympathetic
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Pulmonary ventilation components:
1. _____ that cause lung expansion and contraction 2. Movement of air in and out of the _____ 3. Effect of the thoracic cage on lung _____. |
Muscles; Lungs; Expansibility
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_____ Law: P1V1=P2V2
If pressure increases, the volume decreases If pressure decreases, the volume increases |
Boyle's
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Inspiration:
_____ of diaphragm Action: _____ movement (energy dependent) Effect: _____ chest cavity |
Contraction; Downward; Lengthens
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Expiration:
_____ of diaphragm Effect: _____ chest cavity |
Relaxation; Shortens
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What are these?
1. External intercostals 2. SCM 3. Scalenes 4. Anterior serratus |
Accessory muscles of inspiration
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Accessory muscles of inspiration:
Action: _____ of the ribs Effect: _____ the A-P diameter of chest cavity |
Elevation; Increases
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What are these?
1. Abdominals 2. Internal intercostals |
Accessory muscles of expiration
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Accessory muscles of expiration:
Action: _____ rib cage (Abs also compress the abdominal contents _____ against diaphragm) Effect: _____ chest cavity and _____ A-P diameter |
Depress; Upward; Shortens; Decreases
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Lung characteristics:
1. _____ structure (like balloon) 2. _____ at the hilum to the mediastinum 3. _____ by a thin layer of pleural fluid |
Elastic; Attached; Surrounded
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Continual suction of excess fluid by _____ maintains “suction” between lung pleura and parietal pleura
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Lymphatics
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What is the pressure of the fluid in the thin space between the lung pleura and the chest wall termed?
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Pleural pressure
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What is the pressure of the air inside the lung alveoli termed?
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Alveolar pressure
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Which pressure has these characteristics?
Resting: -5 cm H20 Normal Inspiration: -7.5 cm H20 |
Pleural pressure
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Which pressure increases lung volume by 500 ml?
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Pleural pressure
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Which pressure has these characteristics?
Resting: 0 cm H20 Normal Inspiration: -1 cm H20 Expiration: +1 cm H20 |
Alveolar pressure
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Which pressure allows 500 ml of air in and out of the lung?
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Alveolar pressure
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Which pressure is the difference between the alveolar and pleural pressures?
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Transpulmonary pressure
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Which pressure measures the elastic force of lung called recoil pressure?
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Transpulmonary pressure
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What is the extent to which the lungs will expand for each unit increase in transpulmonary pressure?
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Compliance of the lungs
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The compliance of the lungs is the extent to which the lungs will _____ for each unit increase in _____ pressure.
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Expand; Transpulmonary
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What does this formula describe?
ΔV/ΔP 200 ml/cm H20 (1 cm H20 ~ 0.7 mmHg) |
The compliance of the lungs
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___ of the compliance of the lungs is from the elastic forces of the lung _____.
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1/3; Tissue
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___ of the compliance of the lungs is from the elastic forces caused by _____ _____ of the fluid that lines the inside of walls of _____.
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2/3; Surface tension; Alveoli
[P = (2 x surface tension)/radius of alveolus] |
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Surface tension of the fluid that lines the inside of walls of alveoli is _____ by _____.
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Reduced; Surfactant
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_____ _____ is the attraction of water molecules by each other at the air-water interface and can cause the _____ to collapse.
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Surface tension; Alveoli
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Surfactant is secreted by Type ___ alveolar cells and is composed of dipalmitoyl-phosphatidylcholine, surfactant _____ and _____ ions.
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II; Apoproteins; Calcium
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Which type of work is required to expand the lung against the lung and the chest elastic fibers during inspiration?
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Compliance or Elastic work
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Which type of work is required to overcome the viscosity of the lung and the chest wall structures during inspiration?
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Tissue resistance work
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Which type of work is required to overcome airway resistance and move air into the lung during inspiration?
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Airway resistance work
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_____ Law:
_____ = ΔP π r4 / (8 μ l) _____ = 8 μ l / (π r4) |
Poiseuille's; Flow; Resistance
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Poiseuille's law describes:
1. Major _____ in upper airways 2. Decrease in lung _____ results in an increase in resistance |
Resistance; Volume
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In Poiseuille's law formula, what does μ represent?
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Gas viscosity
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Segmental bronchioles offer _____ resistance than terminal bronchioles do.
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More
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_____ _____ collapses
the airway and increases resistance. |
Forced expiration
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How are pulmonary volumes measured?
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Spirometry
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Pulmonary volume average:
Young adult males is 20-25% _____ than that of women _____ in large and athletic people |
Less; Greater
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There are ___ pulmonary volumes and ___ capacities.
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4; 4
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A pulmonary capacity is _____ than one pulmonary volume.
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Greater
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What pulmonary volume exists during normal quiet breathing?
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Tidal Volume (TV)
~2000 to ~3000 ml |
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What pulmonary volume exists when the maximum amount of air possible is in the lungs?
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Inspiratory Reserve Volume (IRV)
Average male = ~5000 ml (3000 + 5000 = 8000 ml total) |
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What pulmonary volume exists when the maximum amount of air possible has been expired from the lungs?
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Expiratory Reserve Volume (ERV)
~1000* ml (2000 - 1000* = 1000 ml total) |
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What pulmonary volume exists when the minimum amount of air possible is in the lungs?
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Residual Volume (RV)
~1000* ml (2000 - 1000 = 1000* ml total) |
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Which pulmonary capacity equals tidal volume combined with inspiratory reserve volume?
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Inspiratory capacity (TV+IRV)
3000 ml to 6000 ml (~3000 ml) |
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Which pulmonary capacity equals expiratory reserve volume combined with residual volume?
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Functional residual capacity (ERV+RV)
2000 ml to 0 ml (~2000 ml) |
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Which pulmonary capacity equals expiratory reserve volume combined with tidal volume and inspiratory reserve volume?
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Vital Capacity (ERV+TV+IRV)
1000 ml to 6000 ml (~5000ml) |
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Which pulmonary capacity equals residual volume combined with vital capacity?
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Total lung capacity (RV+VC)
0 ml to 6000 ml (~6000ml) |
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What is the total amount of new air moved into respiratory passages each minute termed?
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Minute respiratory volume
(a timed volume) |
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Tidal volume x Respiratory rate = _____ _____ _____
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Minute respiratory volume
(a timed volume) |
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What is the rate at which new air reaches the alveoli, alveoli sacs, alveolar ducts and respiratory bronchioles termed?
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Alveolar ventilation
(a timed volume) |
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(Tidal volume dead space) x respiratory rate = _____ _____
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Alveolar ventilation
(a timed volume) |
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What is air that fills the respiratory passage but where gas exchange does not occur termed?
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Dead space
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What is the total amount of new air moved into respiratory passages each minute termed?
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Minute respiratory volume
(a timed volume) |
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Tidal volume x Respiratory rate = _____ _____ _____
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Minute respiratory volume
(a timed volume) |
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What is the rate at which new air reaches the alveoli, alveoli sacs, alveolar ducts and respiratory bronchioles termed?
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Alveolar ventilation
(a timed volume) |
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(Tidal volume dead space) x respiratory rate = _____ _____
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Alveolar ventilation
(a timed volume) |
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What is air that fills the respiratory passage but where gas exchange does not occur termed?
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Dead space
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The volume of _____ dead space is 150ml.
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Anatomical
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The volume of _____ dead space depends on the ventilation-perfusion ratio.
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Physiological
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Pulmonary _____:
From right ventricle Thin walled Distensible Short vessels Large compliance Deoxygenated blood |
Artery
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Pulmonary _____:
Empties into left atria Short Oxygenated blood |
Vein
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Blood supply to the supporting lung tissue is from the _____ circulation (1-2%).
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Systemic
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Pulmonary _____:
1. Drain into the right thoracic duct 2. Prevent pulmonary edema |
Lymphatics
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_____ _____ pressures (mmHg):
Systolic: 25 Diastolic: 8 Mean: 15 |
Pulmonary artery
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_____ _____ pressures (mmHg):
Systolic: 25 Diastolic: 0 to 1 |
Right ventricle
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The _____ pressure mean is 7 mmHg.
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Capillary
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The _____ _____ pressure is 2 to 5 mmHg.
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Left atria or
Pulmonary vein |
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The total blood volume of the _____ is 450 ml; 9% of total blood volume.
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Lungs
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Pulmonary _____ hold 70 ml of blood.
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Capillaries
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Pulmonary _____ can act as blood reservoirs. Their volume varies from ___ normal volume to ___x normal volume.
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Capillaries; ½; 2
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When O2 in alveoli decreases below normal (<73 mm Hg P02) the adjacent blood vessels _____.
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Constrict
(Opposite of systemic circulation) |
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Low O2 concentration in alveoli triggers the release of an undiscovered _____ substance that shunts blood to where it will be _____.
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Vasoconstrictor; Aerated
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While standing, in the _____ _____ portion of lung, Pulmonary arterial pressure (PAP) - 15 mmHg.
(25-15 = 10) |
Upper most
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While standing, in the _____ _____ portion of lung, Pulmonary arterial pressure (PAP) is normal; 25 mmHg.
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Heart level
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While standing, in the _____ _____ portion of lung, Pulmonary arterial pressure (PAP) + 8 mmHg.
(25 + 8 = 33) |
Lower most
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Capillaries remain _____ when Pulmonary arterial pressure (PAP) > Alveolar pressure.
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Open
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Capillaries remain _____ when Pulmonary arterial pressure (PAP) < Alveolar pressure.
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Closed
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In zone 1 of the lung there is _____ blood flow during all portions of the cardiac cycle.
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No
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Characteristics of lung zone 2:
1. _____ blood flow 2. Blood flow only during _____ 3. Normal in _____ of lung when standing 4. Occurs about 10 cm above _____ _____ heart to top of lung. |
Intermediate; Systole; Apices; Mid level
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If blood flow exists in zone 1 of the lung, it is usually a _____ condition.
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Pathological
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In zone 3 of the lung, there is _____ blood flow during all phases of the cardiac cycle.
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Continuous
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Zone 3 lung is normal in:
1. _____ lung when standing 2. _____ lung when lying down 3. _____ |
Lower; Entire; Exercise
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What increases pulmonary blood flow by 4-7 times normal and increases pulmonary arterial pressure?
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Exercise
(Recruitment and Distension) |
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Exercise increases pulmonary blood flow by:
1. _____: Increases number of open capillaries 2. _____: Distends all capillaries which increases the rate of flow |
Recruitment; Distension
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Pulmonary _____ pressure:
Hydrostatic +7 mm Hg Colloidal osmotic -28 mm Hg |
Capillary
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Time blood stays in pulmonary _____:
Normal Cardiac output 0.8 sec Increased Cardiac output 0.3 sec |
Capillaries
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Capillary net filtration pressure:
Outward forces (mmHg): 1. Pulmonary _____ pressure = 7 2. Interstitial _____ pressure = 14 3. _____ interstitial pressure = 8 (Total = 29) |
Capillary; Osmotic; Negative
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Capillary net filtration pressure:
Inward Force: 1. _____ _____ pressure = 28 mmHg |
Plasma osmotic
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Negative interstitial pressure keeps alveoli _____.
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Dry
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_____ _____ of gas is in one direction and moves from an area of high to low concentration.
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Net diffusion
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_____ gas characteristics:
Percentage: 21% Diffusion coefficient: 1.0 Partial pressure: 160 mmHg |
Oxygen (O2)
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_____ gas characteristics:
Percentage: 79% Diffusion coefficient: .53 Partial pressure: 600 mmHg |
Nitrogen (N2)
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_____ gas characteristics:
Percentage: 0.03% Diffusion coefficient: 20.3 Partial pressure: 760 mmHg |
Carbon dioxide (CO2)
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Gas contributes to total pressure in direct proportion to _____.
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Concentration
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Carbon dioxide is ___ times more soluble than oxygen.
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20
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What is the partial pressure that water molecules exert to escape through the membrane termed?
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Vapor pressure
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At 37° C, _____ _____ of water = 47 mmHg.
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Vapor pressure
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By the time that air reaches the lung it is fully _____.
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Humidified
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What does this formula describe?
Pn[sub2]=(760-47) * 0.79=713*0.79=563 |
Composition of alveolar air
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Due to functional residual capacity only 350 ml of new air is brought into the _____ with each normal respiration.
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Alveoli
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In the process of alveolar ventilation, expired air has alveolar and _____ _____ air.
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Dead space
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Alveolar partial pressure of oxygen (mmHg) _____ as alveolar ventilation (L/min)increases.
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Increases
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Alveolar partial pressure of carbon dioxide (mmHg) _____ as alveolar ventilation (L/min)increases.
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Decreases
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Normal alveolar partial pressure of _____ is 104 mmHg.
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Oxygen (O2)
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Normal alveolar partial pressure of _____ is 40 mmHg.
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Carbon Dioxide (CO2)
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What is comprised by these structures?
1. Respiratory bronchiole 2. Alveolar duct 3. Atria 4. Alveolar sacs |
Respiratory unit
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Oxygen and carbon dioxide diffuse across the respiratory _____.
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Membrane
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_____ _____ is affected by:
1. Thickness of membrane 2. Area of membrane 3. Diffusion coefficient 4. Partial Pressure of gas |
Diffusion capacity
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_____ diffusion capacity is:
21 ml/min/mmHg x gradient of 11 mmHg |
Oxygen
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_____ diffuses across the respiratory membrane at the rate of 230 ml/min.
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Oxygen
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Pulmonary capillary length % _____ with increased partial pressure of oxygen diffused in the blood.
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Increases
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_____ diffusion capacity:
400 ml/min/mm Hg * gradient < 1 mmHg |
Carbon Dioxide
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_____ diffuses across the respiratory membrane at the rate of 200 ml/min.
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Carbon dioxide
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Pulmonary capillary length % _____ with increased partial pressure of carbon dioxide diffused in the blood.
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Decreases
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Partial pressure of oxygen diffused in the blood (diffusing capacity) _____ with time spent in the capillary and _____.
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Increases; Exercise
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Partial pressure of oxygen diffused in the tissue _____ with blood flow.
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Increases
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_____ _____ has PO2 of 90-95 mmHg
_____ has a PO2 of 30-40 mmHg |
Arterial blood; Tissue
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_____ PO2 is determined by balance of delivery and usage.
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Tissue
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Pulmonary capillary length _____ with increased partial pressure of carbon dioxide diffused in the blood.
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Decreases
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Blood flow _____ with increased partial pressure of carbon dioxide diffused in the tissue.
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Decreases
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Dissolved _____ solubility is 0.003 ml _____/100 ml blood mmHg
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Oxygen; O2
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Dissolved _____ solubility in normal blood is 0.3 ml _____ / 100 ml blood
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Oxygen; O2
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_____ oxygen consumption is 250 ml O2/min and would require 83 L/min blood flow.
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Normal
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How is 97% of oxygen is transported?
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Hemoglobin
(O2 + HB <--> HBO2) |
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Hemoglobin (Hb) saturation _____ with increased partial pressure of oxygen in the blood and _____ pH.
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Increases; Increased
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What do these conditions cause?
Decreased pH Increased PpCO2 Increased Temp Increased 2-3 DPG |
Right shift of oxygen dissociation curve
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Right shift of oxygen dissociation curve reflects an _____ partial pressure of oxygen required to achieve the same percent saturation.
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Increased
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What do these conditions cause?
Increased pH Decreased PpCO2 Decreased Temp Decreased 2-3 DPG |
Left shift of oxygen dissociation curve
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Left shift of oxygen dissociation curve reflects an _____ partial pressure of oxygen required to achieve the same percent saturation.
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Decreased
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Effects of _____ _____of the dissociation curve at tissue:
1. Increased carbon dioxide in blood 2. Decreased affinity for oxygen 3. Maintainance of partial pressure gradient |
Right shift
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Effects of _____ _____ of the dissociation curve at lungs:
1. Loss of carbon dioxide at lungs 2. Increased affinity of oxygen |
Left Shift
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Dissolved _____:
Solubility: 20X oxygen Venous blood: 2.7 ml/100 ml blood Arterial blood: 2.4 ml/100 ml blood Transported: 0.3 ml/100 ml blood 7% total |
Carbon dioxide (CO2)
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23% of total _____ is bound to hemoglobin.
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Carbon dioxide (CO2)
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70% of total _____ is in the form of bicarbonate.
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Carbon dioxide (CO2)
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Right and left shifts of the oxygen dissociation curve are also known as _____ effects.
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Bohr
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_____ _____ moves carbon dioxide from the cell into hemoglobin (Hb) and from the blood into bicarbonate.
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Carbonic anhydrase
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Carbonic anhydrase helps to buffer the _____ to 7.3.
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pH
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What is the effect where binding of oxygen with hemoglobin tends to displace carbon dioxide from the blood termed?
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Haldane effect
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_____ is a stronger acid, so binding of oxygen with it tends to displace carbon dioxide from the blood.
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Hemoglobin
(Haldane effect) |
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What is the ratio of the rate of carbon dioxide output divided by the rate of oxygen uptake termed?
|
Respiratory exchange ratio
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The _____ _____ ratio for:
Carbohydrates = 1.0 Fats = 0.7 Mixed diet = 0.825 |
Respiratory exchange
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Respiration regulation:
1. _____ gather information 2. The _____ _____ integrates signals 3. _____ are muscles |
Sensors; Central controller; Effectors
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What is located bilaterally in the medulla oblongata and pons?
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Respiratory center
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Respiratory center organization:
1. _____ respiratory group 2. _____ respiratory group 3. _____ center |
Dorsal; Ventral; Pneumotaxic
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Dorsal respiratory group:
A. Location: dorsal part of _____ 1. _____ _____ nucleus 2. Sensory from CN ___ & ___ B. Input from: 1. _____receptors 2. _____receptors 3. _____ receptors C. Function: _____ |
Medulla; Solitary tract; IX; X; Chemoreceptors; Baroreceptors; Lung; Inspiration (via inspiratory “ramp”)
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Ventral respiratory group.
A. Location: _____ 1. Anterior and lateral to _____ respiratory group 2. Nucleus _____; retro_____ C. Function: extra respiratory _____ (_____ in normal quiet breathing) |
Medulla; Dorsal; Ambiguous; Retroambiguous; Drive; Inactive
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Pneumotaxic Center:
A. Location: _____ upper _____ 1. Nucleus _____ B. Function: _____ inspiration 1. _____ rate 2. Controls _____ _____ point |
Dorsal; Pons; Parabrachialis; Limits; Increases; Switch off
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Which lung receptors?
1. Inhibit inhalation 2. Hering-Breuer reflex |
Stretch receptors
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Which lung receptors?
1. Bronchoconstriction 2. Increased ventilation |
Irritant receptors
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Which lung receptors?
1. Alveolar wall 2. Lung disease and edema |
J receptors
|
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What is this looping sequence?
Inspiratory center -> Phrenic nerve -> Diaphragm contracts -> Stretch receptor -> Vagus nerve --| (-) Inspiratory center |
Hering-Breuer reflex
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Stretch receptors are located in the _____ portion of walls of _____ and _____.
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Muscular; Bronchi; Bronchioles
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Stretch receptors prevent excess lung _____ by switching off the _____ respiratory group of the respiratory center.
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Inflation; Dorsal
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Excess carbon dioxide or excess hydrogen ions in blood greatly _____ the strength of the inspiratory and expiratory centers.
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Increase
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Excess _____ _____ or excess _____ ions in blood greatly increases the strength of the inspiratory and expiratory centers
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Carbon dioxide; Hydrogen
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_____ body - _____ of the _____:
1. Responds to oxygen (greatest Po2<100 mmHg) 2. Responds to carbon dioxide and hydrogen ions |
Carotid; Bifurcation; Carotids
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Changes in arterial PCO2 have _____ effect on control of respiration than changes in arterial pH.
|
Greater
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There is a linear _____ in ventilation with increasing oxygen consumption.
|
Increase
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Arterial PO2, PCO2 and pH do not change in direct correlation to increased _____. PCO2 may _____ slightly.
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Ventilation; Decrease
|
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What are these factors thought to be caused by?
1. Overflow of signals from cortex 2. Body movements 3. Increased body temperature 4. Designed to control PCO2 5. Learned response |
Respiration during exercise
|
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The exact mechanism responsible for increased _____ is not known.
|
Ventilation
|