Nursing Iii Oral Diabetes Meds

Front 1

First-Generation Sulfonylureas

Back 1

Acetohexamide (Dymelor)
Chlorpropamide (Diabinese)
Tolazamide (Tolinase)
Tolbutamide (Orinase)

Front 2

Acetohexamide (Dymelor)

Back 2

First-Generation Sulfonylureas

Front 3

Chlorpropamide (Diabinese)

Back 3

First-Generation Sulfonylureas

Front 4

Tolazamide (Tolinase)

Back 4

First-Generation Sulfonylureas

Front 5

Tolbutamide (Orinase)

Back 5

First-Generation Sulfonylureas

Front 6

First Generation Sulfonylureas
Acetohexamide (Dymelor)
Chlorpropamide (Diabinese)
Tolazamide (Tolinase)
Tolbutamide (Orinase)
ACTION

Back 6

stimulates beta cells of pancreas to secrete insulin

Front 7

First Generation Sulfonylureas
Acetohexamide (Dymelor)
Chlorpropamide (Diabinese)
Tolazamide (Tolinase)
Tolbutamide (Orinase)
SIDE EFFECTS

Back 7

-hypoglycemia
-mild GI symptoms
-weight gain
-interactions, NSAIDS, warfarin, sulfoamides
-sulfa allergy
-skin reactions

Front 8

First Generation Sulfonylureas
Acetohexamide (Dymelor)
Chlorpropamide (Diabinese)
Tolazamide (Tolinase)
Tolbutamide (Orinase)
IMPLICATIONS

Back 8

-monitor for hypoglycemia
-monitor glucose, ketones
-avoid w alcohol

Front 9

Second-Generation Sulfonylureas

Back 9

Glipizide (Glucotrol, Glucotrol XL)
Glyburide (Micronase, Glynase, Dia-Beta)
Glimepiride (Amaryl)

Front 10

Glipizide (Glucotrol, Glucotrol XL)

Back 10

Second-Generation Sulfonylureas

Front 11

Glyburide (Micronase, Glynase, Dia-Beta)

Back 11

Second-Generation Sulfonylureas

Front 12

Glimepiride (Amaryl)

Back 12

Second-Generation Sulfonylureas

Front 13

Second-Generation Sulfonylureas
Glipizide (Glucotrol, Glucotrol XL)
Glyburide (Micronase, Glynase, Dia-Beta)
Glimepiride (Amaryl)
ACTION

Back 13

-stimulates beta cells of pancreas to secrete insulin
-type II diabetes to control glucose
-more potent effects than 1st generation
-can be used in combination with metformin or insulin

Front 14

Second-Generation Sulfonylureas
Glipizide (Glucotrol, Glucotrol XL)
Glyburide (Micronase, Glynase, Dia-Beta)
Glimepiride (Amaryl)
SIDE EFFECTS

Back 14

-hypoglycemia
-mild GI symptoms
-weight gain
-interactions (NSAIDS, warfarin, sulfonamides)
-sulfa allergy

Front 15

Second-Generation Sulfonylureas
Glipizide (Glucotrol, Glucotrol XL)
Glyburide (Micronase, Glynase, Dia-Beta)
Glimepiride (Amaryl)
IMPLICATIONS

Back 15

-monitor hypoglycemia, glucose, ketones
-avoid alcohol

Front 16

Biguanides

Back 16

Metformin (Glucophage, Glucophage XL, Fortamet)
Metformin with glyburide (Glucovance)

Front 17

Metformin (Glucophage, Glucophage XL, Fortamet)

Back 17

Biguanides

Front 18

Metformin with glyburide (Glucovance)

Back 18

Biguanides

Front 19

Biguanides
Metformin (Glucophage, Glucophage XL, Fortamet)
Metformin with glyburide (Glucovance)
ACTION

Back 19

-inhibits production of glucose by liver
-increases body sensitivity to insulin
-used in type II to control glucose

Front 20

Biguanides
Metformin (Glucophage, Glucophage XL, Fortamet)
Metformin with glyburide (Glucovance)
SIDE EFFECTS

Back 20

-lactic acidosis
-hypoglycemia
-drug interactions
-GI disturbances
-not for pts with impaired renal or liver function, resp insufficiency, severe infection, or alcohol abuse

Front 21

Biguanides
Metformin (Glucophage, Glucophage XL, Fortamet)
Metformin with glyburide (Glucovance)
IMPLICATIONS

Back 21

-monitor for lactic acidosis & hypoglycemia
-monitor renal function
-increased risk for renal failure
-interactions

Front 22

Alpha-Glucosidase Inhibitors

Back 22

Acarbose (Precose)
Miglitol (Glyset)

Front 23

Acarbose (Precose)

Back 23

Alpha-Glucosidase Inhibitors

Front 24

Miglitol (Glyset)

Back 24

Alpha-Glucosidase Inhibitors

Front 25

Alpha-Glucosidase Inhibitors
Acarbose (Precose)
Miglitol (Glyset)
ACTION

Back 25

-delay absorption of complex carbs in the intestine...
-slows entry of glucose into systemic circulation
-type II
-used alone or in combination

Front 26

Alpha-Glucosidase Inhibitors
Acarbose (Precose)
Miglitol (Glyset)
SIDE EFFECTS

Back 26

-hypoglycemia
-GI effects (distention, gas, discomfort)
-interactions

Front 27

Alpha-Glucosidase Inhibitors
Acarbose (Precose)
Miglitol (Glyset)
IMPLICATIONS

Back 27

-must be taken with 1st bite to be effective
-monitor GI effects
-monitor liver functions
-hypoglycemia must be treated with glucose NOT sucrose

Front 28

Non-Sulfonylurea Insulin Secretagogues

Back 28

Repaglinide (Prandin)
Nateglinide (Starlix)

Front 29

Repaglinide (Prandin)

Back 29

Non-Sulfonylurea Insulin Secretagogues

Front 30

Nateglinide (Starlix)

Back 30

Non-Sulfonylurea Insulin Secretagogues

Front 31

Non-Sulfonylurea Insulin Secretagogues
Repaglinide (Prandin)
Nateglinide (Starlix)
ACTION

Back 31

-stimulate pancreas to secrete insulin
-type II
-alone or in combination
-rapid action/short half life

Front 32

Non-Sulfonylurea Insulin Secretagogues
Repaglinide (Prandin)
Nateglinide (Starlix)
SIDE EFFECTS

Back 32

-hypoglycemia
-weight gain
-interactions

Front 33

Non-Sulfonylurea Insulin Secretagogues
Repaglinide (Prandin)
Nateglinide (Starlix)
IMPLICATIONS

Back 33

-monitor glucose
-take only if able to eat meal immediately
-before each meal

Front 34

Thiazolidinediones (or glitazones)

Back 34

Pioglitazone (Actos)
Rosiglitazone (Avandia)

Front 35

Pioglitazone (Actos)

Back 35

Thiazolidinediones (or glitazones)

Front 36

Rosiglitazone (Avandia)

Back 36

Thiazolidinediones (or glitazones)

Front 37

Thiazolidinediones (or glitazones)
Pioglitazone (Actos)
Rosiglitazone (Avandia)
ACTION

Back 37

-sensitize body tissue to insulin
-stimulate insulin receptor sites to lower b glucose & improve action of insulin
-alone or in combination

Front 38

Thiazolidinediones (or glitazones)
Pioglitazone (Actos)
Rosiglitazone (Avandia)
SIDE EFFECTS

Back 38

-hypoglycemia
-anemia
-weight gain/edema
-decreases effectiveness of oral contraceptives
-possible liver dysfunction
-interactions
-impaired platelet function

Front 39

Thiazolidinediones (or glitazones)
Pioglitazone (Actos)
Rosiglitazone (Avandia)
IMPLICATIONS

Back 39

-monitor glucose
-monitor liver function
-instruct pt about oral contraceptives not being as effective

Front 40

Dipeptidyl Peptidase-4 (DPP-4) Inhibitor

Back 40

Sitagliptin (Januvia)
Vildaglipin (Galvus)

Front 41

Sitagliptin (Januvia)

Back 41

Dipeptidyl Peptidase-4 (DPP-4) Inhibitor

Front 42

Vildaglipin (Galvus)

Back 42

Dipeptidyl Peptidase-4 (DPP-4) Inhibitor

Front 43

Dipeptidyl Peptidase-4 (DPP-4) Inhibitor
Sitagliptin (Januvia)
Vildaglipin (Galvus)
ACTION

Back 43

-increase & prolongs action of incretin (hormone that increases insulin release & decreases glucagon levels, result of improved glucose control)

Front 44

Dipeptidyl Peptidase-4 (DPP-4) Inhibitor
Sitagliptin (Januvia)
Vildaglipin (Galvus)
SIDE EFFECTS

Back 44

-upper resp infection
-stuffy nose/sore throat
-headache
-stomach discomfort/diarrhea
-hypoglycemia if used with sulfonylurea

Front 45

Dipeptidyl Peptidase-4 (DPP-4) Inhibitor
Sitagliptin (Januvia)
Vildaglipin (Galvus)
IMPLICATIONS

Back 45

-1/day
-alone or with other orals
-monitor renal function