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220 Cards in this Set

  • Front
  • Back

Endocrine System

Secretes hormones into the blood stream

Oxytocin

Milk production


contraction


causes labor


used post delivery to help uterus contract and shrink back to size




secreted from posterior pituitary

Pituitary Gland

containes Anterior lobe and posterior lobe and secretes hormones

Vasopressin (ADH)

causes a faster absorption of water from the kidney into the blood (don't pee hormone)




Causes kidney tubules to save water




potent vasoconstrictor





Stimulus for ADH release

plasma osmolality (solute concentration)


decreased blood volume


decreased BP


pain, N/V, and certain meds




results in concentrated urine

Inhibition of ADH

increased fluid volume


Beta adrenergic agonist


-epinephrine, dobutamine, dopamine


alcohol




results in dilute urine

Diabetes Insipidus

disease caused by failure of the posterior lobe of the pituitary gland to secrete sufficient amounts of ADH




ADH functions to increase the amount of water reabsorbed from the kidney tubules and in its absence large amounts of urine are excreted




F&E losses - dehydration, insatiable, thirst, weakness, weight loss, anorexia

Etiology of Diabetes Insipidus

Tumor, Trauma to pituitary

Treatment of pituitary tumor

transsphenoidal hypophysectomy

Medical Treatments for Diabetes Insipidus

Parenteral Fluids


ADH replacement therapy - parenterally or nasal spray


Intake and Output


Assist in daily care - weak

SIADH

Syndrome of Inappropriate Antidiuretic Hormone




Abnormal production or sustained secretion despite normal plasma osmolarity




causes fluid retention and lower sodium levels




Dilutional Hypernatremia because salt is diluted




too much don't pee hormone




***opposite of Diabetes Insipidus***

Etiology of SIADH



Head Trauma - Pituitary Tumor


Lung CA


Duodenal CA


Pancreatic CA


(Tumors that start producing ADH)




Chronic in nature


must treat underlying cause



SIADH diagnosis

simultaneous urine and serum osmolality




NA< 135 mEq/L plus


Serum osmolality < 280 mOsm/kg


and Urine sp gravity > 1.030



Treatment for SIADH

Fluid restriction (only if NA >125)


---800-1000 cc/day


-----------------------------------------------------


Hypertonic Saline (if NA < 125)


Lasix





Treatments for chronic SIADH

Declomycin


Lithium


Block effect of ADH on renal tubules

pituitary anterior lobe secretes

Growth Hormone


Thhyrotopin


Adrenocorticotropic Hormone (ACTH)


Follicle Stimulating Hormone (FSH)


Luteinizing Hormone (LH)


Prolactine


Melanocyte Stimulating hormone (MSH)

Dwarfism

Congenital deficiency of GH

GIGANTISM

tumor affecting the GH in childhood and adolescence causes the individual to grow extremely tall


ACROMEGALY

hyperescretion of growth hormone




features become coarse, bones become large and heavy,hands and feet become broad and massive, chin protrudes tongue enlarges

Thyroid Gland

regulate metabolism




stores iodine to make thyroid hormone aka TH

hyperthhyroidism

increase in all metabolic processes of the body


overactive thyroid gland




often follows infections or emotional stress




other names : Graves disease, Toxic Goiter



S&S of hyperthyroidism

increase apetite with weight loss


increased BP and HR at REST


Skin warm, perspires freely, sensitivity to hear


fatigue, weakness,


disturbanc of sleep, menstruation, increased bowel movements


profound personality changes


exopthalmos (bug eyed)


mild tremors

Hyperthyroidism Interventions

reduce the activity of the thyroid gland


Antithyroid Drugs


-iodine preparations: SSKI, PTU


-liquids - diluted in fruit juice, administered through a straw, give with meals


-Side Effects - metallic taste, GI discomfort


most useful before surgery or in an emergency




Propanolol for Cardiac Symptoms




Radioactive Iodine - given po - enters into the bloodstream and becomes concentrated in the thyroid gland where it destroys the cells

Radioactive Iodine

after tracer dose is given to determine the correct dose I131 is given orally as single dose




radioactive idone takes 2 weeks to 2 months to work




patient is isolated for 3 days and should avoid close contact with others for 7 days esp pregnant women






urine, saliva is slightly radioactive, vomitus is very radioactive

thyroidectomy

at risk for hemorrhage since the gland is vascular




tetany since the parathyroid glands may be removed




hyperthyroid crisis since the TH may be released during surgery

Hypothyroidism

Under secretion of T4 or comlete lack of secretion

S&S of hypothyroidism

Lack of energy, fatigue, depression, coma, bradycardia, weight gain, cold intolerance

the three conditions associated with hypothyroidism

Goiter, Myxedema, Cretinism

simple goiter

any enlargement of the thyroid gland




results when dietary iodine is insufficient for synthesis




pituitary secretes excessive amounts of TSH causing the gland to hypertrophy

treatment for goiter

prevention - detary iodine and foods high in iodine




reduce the size of the goiter by subtotal thyroidectomy

Myxedema S&S

occurs gradually, sensitivty to cold, dryness of hair and skin, weight gain, loss of appetite, dull facial expression, thickening of lips and eyes, lethargic, responds slowly, decreases HT

Treatment of Myxedema

replace the deficient hormone (T3 levothyroxine, or desicated thyroid) Replacement therapy done gradually slow process - monitor for CV status for bradycardia

Cretinism

complete absence of thyroid secretion from birth




gland may be absent or fail to secrete

S&S of Cretinism

onset few weeks fter birth, difficulty in feeding, FTT, protrusion of tongue, dry skin, constipation, hoarse cry




mandated testing at birth for T4

hyperparathyroidism

Too much parathyroid hormone excretion




causes increased absorption of calcium from gut and cal in the bones is shifted into the bloodstream

causes of hyperparathyroidism

primary - benign tumor of one of the glands


secondary - caused by another disease

S&S of hyperparathyroidism

increasedCa++levels, fatigue, depression, wgt loss, loss of muscle tone, renalcalculi, abdpain, constipation. Weak, tender, and painful bones. Bones dissolve and therewill be pathological fractures

hypoparathyroidism

too little secretion of PTH






Decreasein blood Ca++ and increase in phosphorus.Mostcommon cause - injury or the removal of parathyroid tissue during thyroid orparathyroid surgery.CongenitalabsenceAutoimmuneHypomagnesemia

S&S hypoparathyroidism

Tetany-generalmuscle hypertoniaOverttetany- sudden dropLack of muscular coordination Tremor and spasm, cardiac dysrthymias, laryngeal spasm and generalized convulsions.Latenttetany- gradual drop numbness,tingling, cramps, stiffness in hands and feet



Treatment of hypoparathyroidism

Goal:serum calcium level between 9-10mg/dlIncreaseCalcium levels Calcium gluconateVitaminD preparations ergocalciferol

Adrenal Medulla secretes

Epinephrine - fight hormone


Norepinephrine - Presor Hormone

PHEOCHROMOCYTOMA

Catecholamine-producingtumor of the adrenal medulla. Usually small and benign.


S& S - Hypertension - may be persistent, chronic, or intermittent. Often confused with essentialhypertension. Other symptoms -h/a, N/V,sweating, palpitations, acute anxiety.




24hour urine - elevated metanephrinelevel.




Treatment- removal of the tumor.T.2

Adrenal Cortex

Secretes Glucocorticoids -


regulate cell activity and maintain an optimum internal environment for the body cells . Also regulate the bodys ability to adapt to constant change - regulated by ACTH




Hydrocortison (cortisol)


Corticosterone

Cushings Disease

hyperfunction of the adrenal cortex




cause - usually a tumor in the anterior pituitary gland or adrenal cortex





S&S of cushings

uweaknessof muscle with muscle wasting, fat accumulation in the face, neck, and trunk,“humpback” appearance; Moon face, hemorrhagic tendencies, hirsutism,hypertension, obesity, menstrual irregularities, hyperglycemia, irritability,poor wound healing

Cushing's Treatment

Treatment- Surgical removal of the tumor if possible. May require radiation.


Conveyacceptance to the patient.


Adrenal Steroids - administered in chronicdiseases can lead to Cushing’s syndrome (not disease).

Addisons's Disease

Hypofunctionof the adrenal cortex with decrease in mineralocorticoids (aldosterone) and gluccocorticoids(cortisol). Aldosterone - most important mineralocorticoid - maintainhomeostasis of sodium concentration in the blood.






may be autoimmune destruction of the gland after stressful situation

S&S of Addisons

GIdisturbances, fatigues easily, show signs of hypoglycemia, hypotension,bronzeskin color from increased stimulation to melanocytes

Treatment of Addisons Disease

normalhydration, replacing hydrocortisone and fludrocortisone. Both meds given after meals.

Addisonian Crisis

serious exacerbation of the disease - oroduces a severe drop in B/P --- shock, coma, and death

Addisons Nursing interventions

Fluids high in NA (broth, cola, tomato juice)


monitor BP


monitor weight


monitor K levels

FSH

development of the egg

LH

causes ovulation

Prolactin

causes milk development

Gland that causes Graves Disease?

Thyroid

Gland that causes Diabetes Insipidus

Posterior Lobe of the Pituitary Gland

Gland That causes Cushings Disease?

Adrenal Cortex

Gland that causes Addisons

Adrenal Cortex

Gland that causes Pheocromocytoma?

Adrenal Medulla

S&S of Diabetes Insipidus

Increased Urination

S&S of Addison's Disease

Hyperpigmentation, Hypotension, hypoglycemia

S&S of Cretinism

Dwarfism, Retardism

S&S of Cushings Disease

humpback, hirsutisms, hyperglycemia, trunkal obesity

S&S of hyperparathyroidism

Stones, Bones, Abdominal Groans

Function of Aldosterone

Causes Sodium and Water Reabsorption

Function of Calcitonin

Decreases Serum Calcium

function of ADH

Causes you to retain water

function of thyroid hormones

Controls Metabolism

Function of Parathyroid Hormone

increased serum calcium

Meds: dont stop taking this drug abruptly

Steroids

Report Nasal Congestion with this drug

Vasopressin (ADH)

Blocks synthesis of thyroid hormone

PTU

Dilute in juice and give with a straw

SSKI or Lugols

Start Low Go Slow (medicine)

Synthroid

increased growth hormone in adults

Acromegaly

increased glucocorticoids is what disorder

cushings

decreased growth hormone as a child

dwarfism

decreased ADH is what disorder

Diabetes Insipidus

Increased catecholamines is what disorder

pheocromocytoma

gland responsible for a goiter

thyroid gland

Normal PaO2

80-100 mmHg

gentle bubbling is expected in this chamber of a chest tube?

suction chamber

indicates an air leak in a chest tube?

constant bubbling in the water seal

causes obstruction in the chest tube?

Dependent Loop

reason tidaling may stop in water seal chamber?

obstruction or lung reexpansion

why chest tubes are never left clamped

causes mediastinal shift

presents with hoarseness, dysphagia, or a lump in the throat?

cancer of larynx

may cause partial or total loss of voice

laryngectomy

frequent swallowing with this indicates hemorrhage

Tonsillectomy

used when there is anticipated prolonged intubation, head and neck surgery, trauma to facial features or airwat obstruction

tracheostomy

pinch nose for 10 minutes no peaking

epistaxis

DVT is most common cause

pulmonary embolism

can be spontaneous, from trauma and invasive surgery

pneumothorax

presenting symptoms include fever, chills, tachypnea, crackles, productive cough, retractions, grunting, nasal flaring

Pneumonia

night sweats, weight loss, hemoptysis, fatigue, fever. chills

TB

seen in immunicompromised host with non productive cough

PJP


PCP

Bronchodilator used as an emergency med

albuterol

decrease sputum production by 1/3 if taken for a month

anticholinergics (atrovent)

used to control disease and prevent exacerbations

Inhaled Steroids

used to prophylactically prevent TB in an exposed person

INH

Used to treat TB

INH


Rifampin


Ethambutol


PZA

Adventitious Breath Sounds

Crackles


Rhonchi


Wheezes


Pleural Friction Rubs


Stridor

Pulmonary Function Test

Evaluate Lung function




Measures lung volume, ventilatory function, gas exchange, lung compliance, airway resistance



Thoracentesis

Removes fluid from pleural cavity

aseptic technique


local anesthetic



signs of obstruction

gurgling, increased pulse and respirations, harsh respiratory sound, restlessness, anxiety, pallor with oral cyanosis

Percussion

loosens mucus plugs and moves them into the bronchi




rhythmically clapping and vibrating

antitussive

cough medicine


narcotic - codeine


nonnarcotic - dextromethorphan

Demulcents

relieve irritation, soothe, protects mucus membranes




cough medicine

Expectorants

thins secretions, to facilitate expectoration




cough medicine

Sedatives

depress cough reflex

Neosynephrine


Ephedrine Sulfate

Nose drops or sprays for nasal congestion and can cause rebound nasal congestion

low flow oxygen delivery devices

Nasal cannula, face mask, non-rebreather

High flow oxygen delivery devices

Venturi Mask, Trach Collar

precautions with oxygen

No smoking sign outside door and in room


do not use electrical appliances


secure portable tanks


don't place them near source of heat


** o2 can cause toxicity**

signs of o2 deficiency

restlessness, excitement, confusion, increased R and PR, headache, sighing and yawning, N&V, Anorexia

late signs of o2 deficiency

Decreased BP, Cyanosis, twitching of muscles

Endotracheal Intubation

Increases oxygenation


allows for suctioning


inserted through nose or mouth


use in surgery but also in emergency situations to facilitate breathing


ventilate by mechanical means

Thoracotomy

Surgical opening into thoracic cavity to remove blood, pus, air, or to expedite the re-expansion of the lung to explore the thoracic cavity

lobectomy

removal of an entire lobe

pneumonectomy

removal of an entire lung

Chronic Bronchitis

dx by symptoms: presence of cough for at least 3 months in each of two consecutive years, increase in mucous secreting cells




bronchi become thickened and bronchioles become fibrosed




normal function of cilia is impaired

Chronic Bronchitis S&S

persistent cough with large amounts of thin sticky liquid mucous


SOB


Dyspnea


Cyanosis


Wheezing

Chronic Bronchitis Interventions

healthy lifestyle


Stop Smoking


Avoid exposure to infections


Antibiotic Therapy


Medications have limited effects (except antibiotics)

Pulmonary Emphysema

Alveolar walls and capillaries are destroyed which decreases the area available for exchange of gases between bloodstream and air




cigarette smoking is the largest contributing factor

S&S of Pulmonary Emphysema

Insidious Onset


Dyspnea


Hypoxia


Coughing with copious amounts of mucopurulent sputum


Barrel shaped chest


use of accessory muscles


wheezing


pneumothorax

Pulmonary Emphysema interventions

Prevention, Antibiotics, Cough and deep breathe, incentice spirometry, aerosilized bronchidilators, low levels of oxygen, nutrition



Coniditions associated with pulmonary emphysema

Right sided HF


Chronic Bronchitis


peptic ulcer and GERD


Exacerbations of COPD


acute resp failure


Depression/ Anxiety



Asthma

Bronchi become narrow and edematous


Spasms of bronchial muscles occur


no cure

Asthma Triggers

infection, allergies, exercise, irritants

S&S of Asthma

SOB, Wheezing, Coughing

Anti inflammatory Drugs for Asthma

corticosteroids


mast cell stabilizers


leukotriene modifiers


monoclonal antibody to IgE

Bronchodilators for Asthma

B2 adrenergic agonist drug


methylxanthines


anticholinergic drugs



Asthma Interventions

Epinephrine, steroids and bronchodilators for relief of immediate attack




control causative factors


promotion of healthy lifestyle


prevention of exacerbation's with inhaled corticosteroieds

S&S of cancer of the larynx

Hoarseness


Pain


Burning throat with juices/ hot liquids


lump in throat

Late S&S of cancer of the larynx

dysphagia


dyspnea


continued hoarseness


foul breath


enlarged lymph nodes (metastasis)



Dc of cancer of the larynx

Direct Visualization


Biopsy


CT scan

Treatment for cancer of the Larynx

Laryngectomy


Radiation

Care for Laryngectomy Tube

Shorter and wider than a trach tube


stoma heals in 3-6 weeks


keep clean/ wash BID


Avoid any water - shower with plastic bib


No oil based ointments near stoma


AC may be too cold and dry to tolerate



Pulmonary Embolism

Occurs when a blood clot or other foreign matter becomes lodged in a branch of the pulmonary artery or arteriole

Pulmonary Infarction

is the death of a portion of lung tissue resulting from an insufficient blood supply, often is a result of a pulmonary embolis



PE risk factors

Immobility


Surgery


Cancer


Pregnancy



Pneumonia

Most common infectious cause of death in the US


Lobar - substantial portion of one or more lobes


Bronchopneumonia - patchy fashion bronchi > lungs

Causes of Pneumonia

Opportunistic Bacterial


Viral


Fungal


Parasitic


Post radiation, post-chemical ingestion


Aspiration

Risk factors for Pneumonia

CA, COPD


Smokers


Immobility


Decreased cough reflex


Aspiration


NPO

Bacterial Pneumonia S&S

Sudden onset - affects one or more lobes


Chest pain, myalgia, H/A


increased T, P, R Severe Chills


Cough - thick sputum


Crackles ^ tactile fremitus


WBC - 20k-30k

Viral Pneumonia S&S

chills


elevated temp - irregular


profuse sweating


body aches


painful cough


WBCs normal

PJP

Fungus causing disease in immunocompromised host




manifests with fever chills non productive cough SOB dyspnea Tachypnea tachycardia hypoxemia occasional chest pain




treatment is Bactrim

Pneumonia Interventions

Avoid energy expenditure


antibiotics


analgesics


cough analgesics


increase humidity


o2


increase fluids



TB

Airborne droplet


Acid fast bacterium



TB S&S

Cough -dry, productive, hemoptysis


pleuritic chest pain


systemic effects


-weigh loss


-night sweats


-fever


-malaise


-anorexia


-fatigue



Central Nervous System

Brain, Spinal Cord

Peripheral Nervous system

Cranial nerves, spinal nerves, and autonomic nervous system



GCS

used for Level of Consciousness




lowest score is a 3 - comatose client or completely unresponsive

Cranial nerve I

Olfactory - smell

CN II

Optic - visual fields and acuity



CN III

Occulomotor



CN IV

Trochlear

CN VI

Adbucens



CN 3,4,5 responsible for

PERRLA - 6 cardinal positions of gaze - Eyes

CN V

Trigeminal - light touch - chewing, jaw opening, clenching

CN VII

Facial - Taste, Facial movements

CN VIII

Auditory - Hearing and balance

CN IX

Glossopharyngeal - Taste

CN X

Vagus - swallowing, speech sounds, gag reflex


CN XI

Spinal Accessory Nerve


Turning head and shrugging shoulders

CN XII

Hyopglossal - tongue movement

Musculoskeletal changes expected with aging?

Reduced muscle mass


Slower reaction time


Decline in coordination


Limited ROM

Neurological changes expected in aging?

Decreased in taste and smell


Decrease in tactile sensation


Decreased Temp regulation


Visual Changes


Loss of hearing


Stage IV sleep is decreased


Fewer brain cells, neurotransmitters, smaller brain volume


Slowed Reflexes (DTR)


Decline in short term memory.

Findings that do NOT change in normal aging

Touch, orientation, language, LOC, memory, judgement


-- may take longer to process, but does not diminish--





CT scan

provide cross sectional views of the brain showing differences in tissue density

Episodic Migraines

fewer than 15 headache days a month - only some are migraines

Chronic Migraines

occur 15 or more days a month and headache lasts 4 hours or longer for at least 3 months

Migraine Risk factors

family hx, increased body weight, HTN, hypercholesterolemia, impaired insulin sensitivity, stoke, CAD

Triggers for migraines

menstrual cycle, dietary habits, bright lights, stress, depression, lack of slep, meds, alchohol, foods (cheese, chocolate, milk products, coffee, tyramine, MSG)

Phases of migrain

Prodrome - 60% of patients


Aura - minority of patients - last 1 hour visiaul disturbances are most common


Headache Phase - 4-72 hours, unilateral throbbing pain with N/V


Recovery - characterized by deep sleep - pain subsides

Abortive Migraine meds

--Triptans


Imitrex (sumatriptan)


Amerge


Maxalt


Zomig


Axert




Ergotamines


Ergotamine tartate


cafergot (caffeine)




Antiemetics

Preventative Migraine Meds

Antiepileptic drugs (neurontin, topamax and depakote)


Beta blockers (lopressor, inderal)


Antidepressents (elavil)


Calcium Channel Blockers (Verapamil)


NSAIDS


Botox



Seizures

Abrupt, abnormal, excessive, and uncontrolled electrical discharge of neurons in the brain that interrupts the normal function

Epilepys

A condition in which a person has spontaneously recurring seizures caused by a chronic underlying condition or unknown cause

Status Epilepticus

continuous seizure activity without full recovery of consciousness between seizures

Intervention for Status Epilepticus

Establish Airway and Oxygenation


IV meds given to stop seizure - Valium, Ativan, or Cerebyx
Other meds given later (dilantin and phenobarbital) to maintain seizure-free state

Causes of Seizures

Fever


Infection


Head Trauam


Alcohol, Drug Withdrawal


Brain Tumor


Cerebral Edema


Metabolic Disorders


Hypoxia


CVA


HTN


Electrolytes


Allergies


Lead Poisoning


Unknown

Myoclonic Seizures

*brief jerking or stiffening of extremities *symmetrical or asymmetrical

Stages of Seizures

Aura - alterations in smell, taste, visual perception, hearing, and emotional state


Ictus - when seizure occurs


Post Ictal - brain recovers, drowsiness and confusion are common

Pharm for Seizures

Tegretol


Neurontin


Lamictal


Keppra


Dilantin


Topamax


Depakote


Klonopin

Septic Meningitis

Caused by bacteria (bacterial meningitis)




HIGH MORTALITY RATE

Aseptic Vital Meningits

secondary to lymphoma, leukemia, or HIV, Chickn pox, herpre simplex (typically type 2)


mumps, measles, west nile, rabies




Fungal - common in clients with AIDS

Kernigs and Brudzinski's

Differentiates between meningitis and encephalitis




Encephalitis

Acute inflammation of brain tissue

causes of Encephalitis

Virus - usually herpres simplex virus/ HSV is most common in the US




presents with : fever, HA, N/V, could have seizures and altered LOC (Confusion, drowsiness)

Treatment for Encephalitis

Zovirax - antiviral given for up to 3 weeks


Antiseizure meds if needed

MS

Chronic, progressive, degenerative disease with no cure




destruction of the myelin sheath

Dx of MS

MRI - presence of multiple plaques in the CNS


CSF Analysis/ LP - increased IgP


ER - Evoked Potential - Measures time it takes for nerves to respond to stimulation

Treatment for MS

Goal - treat acute exacerbations, delay progression and manage chronic symptoms

Pharm for MS

Novantrone


corticosteroids


meds to treat specific symptoms

Myasthenia Gravis/ MG

Autoimmune disorder of neuromuscular junction


-Antibodies attack acetylcholine receptor sites resulting in varying degrees of muscle weakness



Myasthenia Crisis

Acute exacerbation of muscle weakness can lead to resp failure



Diagnostic

Tensilon IV (acetylcholinesterase inhibitor)


MRI - enlarged thymus


Serum Analysis - increased acetylcholine antibodies


EMG - Detects delay/ failure of neuromuscular transmission

Medical Management of MG

1st line - anticholinesterase medications - mestinon


2nd line - immunosuppressives - Corticosteroids


Exacerbation - plasmapheresis and IVIG




Surgical intervention - thymectomy

Guillain - Barre Syndrome

caused by autoimmune attack that results in the direct destruction of the myelin sheath surrounding the PNS or the axon of the nerve itself

Diagnosis of Guillan-Barre

Hx of terminal illness


LP


EP

Trigeminal Neuralgia

5th cranial nerve. unilateral shooting and stabbing pain


due to blood vessel pressing on trigeminal nerve, injury to TN, or inflammation of TN

Triggers of Trigeminal Neuralgia

Chewing, brushing teeth


Cold or hot air on the face


Touching/ washing the face


Talking, Yawning, Shaving

DX of Trigeminal Neuralgia

MRI and assessment to rule out other causes

1st line drug for Trigeminal Neuralgia

Tegretol

Tensilon Test

Used to diagnose MG

Bell's Palsy

a form of temporary facial paralysis resulting from damage or trauma to the facial nerve




*Unilateral inflammation of the facial nerve which results in weakness or paralysis of the facial muscles on one side of the face

Goal of Treatment for Bells Palsy

Apply hear to promote comfort and blood flow


electrical stimulation to prevent muscle atrophy




Pharm - Corticosteroid therapy - to reduce inflammation


analgesic for pain

ALS

Lou Gherigs Disease - type of motor neuron disease that causes nerve cells to gradually break down and die

Dx of ALS

based on signs and symptoms


EMG and muscle biopsy will show a reduction in the number of functioning motor units

Management of ALS

Rilutek - reduces damage to motor neurons


Baclofen and Valium - for spasticity

Parkinsons Disease

a progressive disorder of the nervous system that affects movement




Decreased level of dopamine




caused by destruction of nerve cells which causes an imbalance between dopamine and acetylcholine

Cardinal signs of parkinsons

TRAP


Tremor


Rigidity


Akinesia


Postural instability



Thrombotic Stroke

ischemic/blockage/area of plaque/stationary clot

Embolic Stroke

- ischemic/blockage/traveling clot

Hemorrhagic Stroke

brain bleed from ruptures BV/aneurysm

TIA

Temporary loss of neurologic function

CVA classic deficits

Hemiplegia


hemiparesis


unilateral neglect

Stroke FAST

Face - uneven look


Arm - one arm hanging down


Speech - slurred speech


Time - call 911!

Dx of a stroke

CT scan is initial diagnostic test


ECG


Cerebral Angiography


Carotid Ultrasound


MRI/MRA


LP - blood in CSF - hemorrhagic stroke