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7 Cards in this Set

  • Front
  • Back

Function of the nucleus

  • Directs protein synthesis
  • Synthesis of rRNA. mRNA, tRNA, noncoding RNA

Nuclear Lamina


  • Supports the inner surface of the nuclear membrane
  • Composed of Lamins (intermediate filaments)

Lamins


  • Assist in the formation of nuclear pore complexes
  • Responsible for the ordered disassembly and reassembly of the nuclear envelope during mitosis

Phosphorylation of Lamins

  • Leads to disassembly - break down of Nuclear Membrane

Dephosphorylation of lamins

  • Results in the reassembly of the nuclear envelope

Laminopathies that result from mutation in the Latin A gene

  • Premature aging
  • Muscular Dystrophy
  • Cardiomyopathy
  • Lipodystrophy
  • Progeria

Hutchinson-Gilford Progeria Syndrome

  • Mutation in Lamin A gene (Lamin A and C)
  • unable to bind to inner nuclear membrane