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27 Cards in this Set

  • Front
  • Back

3 factors RNI is usable in NM:

1. Same chemicle properties to its stable isotope- follows the same physiologic pathways.




2. Emits gamma radiation




3. Tag to physiologic compounds chemically to radionuclide

Graph of line of stability; Above the line = ?
Below the line = ?

Above line: neutron excess, below line, neutron deficiency

Line of Max stability, at low Z, N = ?
at high Z, N = ?

Low Z, Z = N
High Z, N > Z

Three types of decay process

Alpha, Beta, Positron

All accompanied by Gamma

4 Types of Primary Decay

Alpha, Beta, Position, Electron Capture

3 types of Secondary Decay

Gamma, Isometric Transition, Conversion Electron

Alpha decay,
Energy
Range
Ionisation


What is released

1-6 MeV


mm/cm in air


Highly ionising


4He2

Beta decay,


Energy


Range


Ionisation


What is released

3 MeV


cm/m in air


Moderately ionising


0e-1

Positron decay,


Reaction


When will it occur



Internal pair production


Electron remained in nucleus, positron emited


Occurs when there is too few neutrons in nuclei, N value below the stability belt.

Electron capture,


How does it happen


What is released



K-shell capture, characteristic radiation released


electron disappears and a proton in the nucleus become neutron, releasing gamma and neutrino

Isometric transition,


What is isometric transition

A transition from metastable state ( isomer )



Internal conversion,
How it happen


What is emitted

Energy of gamma ray given to electron, escapes from atom.


Characteristic radiation is emitted.

Isobars, Isotopes,Isotones,Isomers,Isodiapheres

Same A, same Z, same N, same A and Z, having excess number of N

Chart of nuclides;


Gray represents what?
Rectangle?
Small black triangle/squares?


Question mark?

stable/long half-lives, naturally occuring, fission products, uncertain

Activity formula and definition

number of radioactive nuclei that disintegrate in a sample per unit time.




At =A0e^-Lt, L = Lamda

What are the SI unti for disintegration rate

Bq and Ci



1 Ci = ? Bq

3.7 x 10^10 dps

Physical half-life formula

T = 0.693/L

Effective half- life?

Radiation dose patient will recieve

Biological half-life?

Time taken for the radionuclide to be excreted from the body.

Photon energy of radionuclide allowed for NM

50 - 500 keV

Average/mean life

Average lifetime of all the atoms in the given sample and is defined as the ratio of the total lifetime of all the atoms to the total number of atoms.

Half life of:


Tc-99m


I-123


I-131


TH-201

6 h


13 h


8 days


73 h `

What is the ideal energy for gamma camera to pick up

150 keV

What are the 4 mechanisms for localising radiopharmaceuticals?

Phagocytosis (Bone, spleen, liver),


Diffusion( kidney),


Capillary blockade,


metabolism (thyroid)

2 types of generator and their differences

Dry and wet type




Dry- inconvenient, less impurites, easier to maintain




Wet- convenient, more impurities, hard to keep sterility

3 routes of administration

IV


Oral


Inhalation