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9 Cards in this Set
- Front
- Back
- 3rd side (hint)
What are the four basic terms?
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Drug - Any chemical that can affect living processes.
Pharmacology - The study of drugs and their interactions wiht living systems. Clinical Pharmacology - The study of drugs in humans. Therapeutics (or Pharmacotherapeutics) - use of drugs to diagnose, prevent, or treat disease or to prevent pregnancy. |
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What the properies of an IDEAL drug?
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Effectiveness - most important property; elicits the response for which it is given.
Safety - cannot produce harmful effects (even in high doses and for a very long time). Selectivity - drug elicits only the response for which it is given (NO SEs). |
No such thing as a perfect or SAFE DRUGS
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Additional Properties of an Ideal drug
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Reversible action, predictability, ease of administration, freedom from drug interactions, low cost, chemical stability, and simple generic name
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Therapeutic Objective
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Provide maximum benefit with minimum harm
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Factors Determining Intensity of Drug Responses
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Administration - dosage, route, and timing of administration; primary determinent of concentration; if drug not administered correctly results maybe toxic or treatment failure; give complete instructions about med and how to take it.
Pharmacokinetics - how the body affects drugs, impact of body on drugs. Pharmacodynamics - how the drug affects the body; impact of drugs on body; initial step leading to a response is the binding of drug to its receptor (drug-receptor interaction), followed by sequence of events that results in a response; Pt's functional state can influence pharmacodynamic process and Placebo effects also help determine responses. |
is the ultimate concern; is determined by the concentration of the drug at its sites of action
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Pharmacolinetics - how the body affects drugs
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Drug absorption
Drug distribution Drug metabolism Drug excretion |
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Individual Variations in drug interactions
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Physical - age, gender, and wt.
Genetics. Pathophysilogy - liver and kidney function/major organs of drug elimination |
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Chapter I KEY POINTS
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Goal is to use med to promote desired effects and minimize SE.
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Principle determinants of drug response
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Pharmcokinetics and Pharmacodynamics and individual variants
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Regiment is tailored to individual and should produce maximum benefit with minimal harm.
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