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12 Cards in this Set

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Malignant neoplastic growth is characterized by:
Unregulated cell proliferation
What is the challenge in making anticancer drugs?
Killing malignant cells but allowing normal cells to live.
What are Antimetabolites?
Compounds that mimic the intermediates of cellular metabolism
How do the antimetabolites act in general?
By inhibiting or interfering with metabolic pathways.
What metabolic pathway is esp targeted by anticancer drugs?
Nucleotide synthesis
2 ways to synthesize Purines:
-De novo
-Salvage of bases via APRT & HPRT
2 ways to synthesize Pyrimidines:
-De novo
-Salvage of nucleosides via nucleoside kinases
What pathway is used most by
-Normal cells
-Cancer cells
Normal = 90% salvage
Cancer = much more De Novo!
3 Categories of antimetabolites used to target NT metabolism:
1. Antipurines
2. Antipyrimidines
3. Antifolates
What ARE the antipurines?
Thiopurines:
-6-Mercaptopurine
-6-thioguanine
What is the major use of antipurines?
Maintainence of childhood leukemia
What does each mimic:
6-mercaptopurine
6-thioguanine
mercapto = hypoxanthine

guanine = guanine