Nsaids And Inflammation

Front 1

What is the new clinical sign of inflammation? What are the 4 original signs?

Back 1

loss of FXN, reddess, heat, pain, swelling

Front 2

What is the first event of inflammation?

Back 2

changes in blood flow--this gives you heat and reddess

Front 3

What is the 2nd event of inflammation?

Back 3

Permeability changes--this causes swelling and pain

Front 4

In inflammation, white cells break down and release ___?

Back 4

phospholipids

Front 5

phospholipids break down into ____?

Back 5

prostaglandins

Front 6

what is the enzyme that cleaves phospholipids to produce arachidonic acid?

Back 6

Phospholipase A2

Front 7

Steriods inhibit what enzyme?

Back 7

phospholipase A2

Front 8

NSAIDS block which enzyme?

Back 8

Cyclo-oxygenase

Front 9

_____ and ____ block the Cox pathway.

Back 9

aspirin and acetaminophen

Front 10

What are the 4 products of prostaglandins?

Back 10

1- PGE2
2- PGF2
3- PGI2
4- TxA2

Front 11

PGE2 causes ___ and ____ and _____?

Back 11

vasodilation, pain sensitizstion, and gastric cytoprotection

Front 12

PGF2 causes ___ and ___?

Back 12

bronchoconstriction and uterine contraction

Front 13

PGI2 causes ___ and _____?

Back 13

Inhibition of platelet aggregation, and gastric cytoprotection

Front 14

TxA2 causes _____?

Back 14

platelet aggregation

Front 15

What is a side effect of a drug that blocks PGE2?

Back 15

gastric ulcers (no more gastric cytoprotection)

Front 16

What can baby aspirin be used to treat? What "kind of " drug is this?

Back 16

High blood pressure. It is an anti-platelet aggregation drug.

Front 17

What are the 3 things that COX-1 causes?

Back 17

1- cytoprotection of GI
2- platelet activity
3- renal function

Front 18

If someone has a gastric ulcer, but they need some sort of anti-inflammatory drug, what would you give them? why?

Back 18

COX-2 inhibitor, b/c this will block pain and fever-but will not bother the platelet activity of the gut.

Front 19

THe first NSAID discovered was ____?

Back 19

Salicylate

Front 20

The ______ profile will determine what is the best drug to ues.

Back 20

side effect

Front 21

Is acetaminophen an anti-inflammatory drug.

Back 21

NO NO NO!!!

Front 22

For what purpose is acetaminophen used for?

Back 22

fever and pain

Front 23

Why do we not use aspirin in kids?

Back 23

It could cause Reyes syndrome

Front 24

Glucocorticoids block ____?

Back 24

phospholipase

Front 25

NSAIDS block _____.

Back 25

COX 1 and 2

Front 26

What are 4 effects of NSAIDS?

Back 26

1- anti-inflammatory
2- analgesics
3- antipyretic
4- decrease platelet formation

Front 27

What are 2 side effects of NSAIDS?

Back 27

GI intolerance and ulceration (it has been known to cause dizziness and confusion and bronchoconstriction)

Front 28

What are the 3 symptoms of aspirin overdose?

Back 28

1-ringing in the ears
2- increased heart rate
3- you stop breathing

Front 29

How is PGE so gastroprotective?

Back 29

it enhances bicarbonate secretion and blood flow. It promotes mucus secretion and epithelial cell growth.

Front 30

What are 5 renal association problems with NSAIDS?

Back 30

1- Na retention
2- HTN
3- hyperkalemia
4- decreased blood flow
5- interstitial nephritis

Front 31

Name 5 nonselective COX inhibitors.

Back 31

1- aspirin
2- acetaminophen
3- indomethacin
4- ibuprofen
5- naproxen

Front 32

Which NSAID has the shortest half life?

Back 32

aspirin

Front 33

Desribe the tricky half life if aspirin.

Back 33

The antipyretic effect is gone in 4 hours but the acetyl part( anti-platelet) lasts for about 8-10 days.

Front 34

Aspirin is a non-selective ______ inhibitor of COX.

Back 34

irreversible

Front 35

Ibuprofen is a _____ inhibitor of COX.

Back 35

reversible

Front 36

Ibuprofen is found in which 2 common OTC drugs?

Back 36

1- motrin
2- advil

Front 37

___ doses of ibuprofen produce analgesic but not anti-inflammatory effects.

Back 37

low

Front 38

T or F: selective COX-2 inhibitors are 300X more selective for COX-2 than COX-1?

Back 38

True

Front 39

Name 3 names of selective COX-2 inhibitors.

Back 39

1- Celebrex
2- Vioxx
3- Bextra

Front 40

Why were some selective COX-2 inhib itors pulled off of the market?

Back 40

They cause increased thrombotic events.