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11 Cards in this Set
- Front
- Back
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NSAID similarities to aspirin
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- Anti-inflammatory
- Analgesic - Antipyretic - Anti-thrombotic |
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NSAID differences from aspirin
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- produce +/- side effects
- greater tissue distribution - more potent - longer duration Unlike aspirin, NSAIDs are IRREVERSIBLE COX inhibitors |
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Those who are allergic to aspirin
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Will also be allergic to other NSAIDs that inhibit COX
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Indomethacin
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- Potent anti-inflammatory agent (AIA)
- anti-pyretic - some analgesic Use: - rheumatoid arthritis when aspirin ineffective. - ankylosing spondylitis - acute gout - patent ductus ductus arteriosus - Barrter's Syndrome SE: frontal headache, GI and hematopoetic problems |
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Sulindac
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(Derivative of indomethacin)
- AIA - analgesic - anti-pyrectic Use: - rheumatoid arthritis - osteoarthrosis SE: occassional GI effecs, few headaches compared to indomethacin |
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Naproxen
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- Less AIA than indomethacin
- anagelsic - anti-pyretic Use: rheumatoid arthritis SE: occasional GI effect |
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Diclofenac
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- Potent AIA*
* accumulates in the synovial fluid Use: - rheumatoid arthritis - osteoarthritis - ankylosing spondylitis SE: GI effects |
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Piroxicam
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- Good AIA
- long plasma half life Use: - rheumatoid arthritis - osteoarthrosis SE: - better tolerated than ASA or indo. - some GI problems |
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Ketorolac
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COX Inhibitor with strong analgesic properties
Use: oral & injectable for acute pain, post-operative analgesia, adjunct use in surgery. - Not used for chronic inflammation - Kidney damage upon use for more than 5 days possible SE: minor, same as other COX inhibitors. Not for obstetrical use |
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Celecoxib (Celebrex)
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Selective COX-2 inhibitor at normal therapeutic doses. Minimal activity on COX-1
Use: FDA approved for osteoarthritis and RA SE: Like other NSAIDs except with less ulcers and little/no effect on bleeding time |
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Ibuprofen (Motrin, Advil)
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- Less anti-inflammatory activity than indomethacin
- analgesic - anipyretic Use: - dysmenorrhea (abnormally painful menstrual cramps) - rheumatoid arthritis - oseoarthrosis - mild to moderate pain SE: well tolerated, few GI effects |
