• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

Card Range To Study

through

image

Play button

image

Play button

image

Progress

1/51

Click to flip

Use LEFT and RIGHT arrow keys to navigate between flashcards;

Use UP and DOWN arrow keys to flip the card;

H to show hint;

A reads text to speech;

51 Cards in this Set

  • Front
  • Back
-ac
anti-inflammatory
acetic acid derivaties
diclofenac
etodolac
-butazone
anti-inflammatory analgesics
pheynlbutazone type
phenylbutazone
-coxib
cyclooxygenase - 2 inhibitors
deracoxib
firocoxib
-fenamic
anti-inflammatory
anthranilic ace derivative
tolfenamic acid
-icam
anti-inflammatory
meloxicam
piroxicam
-metacin
anti-inflammatory
indomethacin type
indomathacin
-nixin
anti-inflammatory
anilinonicotinic acid derivative
flunixin
-profen
anit-inflammatory/analgesic agent
ibuprofen type
carprofen
ketoprofen
-sal
-sal-
sal-
anti-inflammatory
aspirin
acetyl salicyclic acid.
Cox 1 characteristics
ER membrane bound
many tissues and blood
blood clotting
reg of vascular homeostasis
renoprotection, gastroprotection
coordination of hormones
Cox 2 characteristics
induced by proinflammatory cytokines, growth factors, LP, pro and antiinflammatory mediators
Down regulated by steroids
What are the major species differences of the PK parameters of NSAIDS
Half life, and clearance
Selective COX-1 inhibitors
Aspirin
Ketoprofen
Flunixin
Phenylbutazone
Selective COX-2 inhibitor
Deracoxib
Firocoxib - highly selective
Carprofen
Meloxicam
Aspirin
Selective COX 1 inhibitor
Irreversible effect on platelet aggreggation
Ketoprofen
COX -1 inhibitor
Propionic acid derivative
Piroxicam
COX - 1 inhibitor
Adjuctive therapy for transitional cell carcinoma of the urethra and bladder
Phenylbutazone
COX -1 inhibitor
Enolic acid
Most used in horse
Deracoxib
COX - 2 inhibitor
Firocoxib
Cox - 2 inhibitor
Acetominophen
Not approved for use in animals
Not a COX inhibitor
metabolism creates toxic intermediate in cats
Carprofen
1st NSAID approved for dogs, anti-inflammatory, analgesic
Propionic acid derivative
Diclofenac
acetic acid derivative
Etodolac
acetic acid derivative
Flunixin
approved in cattle, no chronic use in dogs due to GI sensitivities
Flurbiprofen
Not approved in animals
ophthalmic preparation
pH balanced, non-irritating
Ibuprofen
not approved in animals
Meloxicam
not approved in cats
Naproxen
not approved in animals
Piroxicam
used to treat transitional cell carcinoma, but not anitneoplastic, not used as anit-inflammatory
Tepoxalin
works to decrease PGs and leukotrienes, COX and LOX blocker
Bovine/Caprine/Ovine/Porcine NSAID
Flunixin
Equine NSAID
Phenylbutazone
Flunixin
Canine NSAID
Carprofen
Meloxicam
Feline NSAID
no good choice
Meloxicam only once
Avian/Exotic
Meloxicam
Whole animal response to NSAIDS
analgesic, antipyretic, antiinflammatory, antithrombotic, and antiendotoxemic
Inihibition of Cox 1 can cause
toxic effects such as elimination of gastro and renal protective mechanisms
Cox 1 is responsible for production of what inflammatory mediators
TxA2, PGE2, PGI2
Expression of Cox 2 is increased on exposure to
LPS, IL-1, TNFa, growth factors, bacterial toxins, mitogens, immune and inflammatory stimuli
Cox -2 is downregulated by
glucocorticoids at mRNA level
Highly selective Cox 2 inhibitors
Etoricoxib, firocoxib, lumiracoxib, robenacoxib
Which species has the longest NSAID half life?
Man
PG effect GI mucosa by ______ so NSAIDS _____
increasing mucous production
decrease mucous production
Hepatotoxicity associated with NSAIDS is what type of adverse reaction?
Type 2, no known mechanism
Horses have lower toxicy reaction to NSAIDs because
It is less protein bound, so lower serum concentration levels are necessary.
Dogs have higher renal toxicity occurance with NSAIDs compared to other species because
Dogs have higher Cox 2 enzyme in kidney than other species
Flunixin is approved for use in _____ .
horses, cattle and swine
In horses flunixin is approved for the treatment of
inflammation andpain associated with musculoskeletal disorders and pain of colic
In cattle, flunixin is approved for the treatment of
pyrexia of BRDand endotoxemia
In swine, flunixin is approved for
pyrexia of SRD