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51 Cards in this Set
- Front
- Back
-ac
|
anti-inflammatory
acetic acid derivaties diclofenac etodolac |
|
-butazone
|
anti-inflammatory analgesics
pheynlbutazone type phenylbutazone |
|
-coxib
|
cyclooxygenase - 2 inhibitors
deracoxib firocoxib |
|
-fenamic
|
anti-inflammatory
anthranilic ace derivative tolfenamic acid |
|
-icam
|
anti-inflammatory
meloxicam piroxicam |
|
-metacin
|
anti-inflammatory
indomethacin type indomathacin |
|
-nixin
|
anti-inflammatory
anilinonicotinic acid derivative flunixin |
|
-profen
|
anit-inflammatory/analgesic agent
ibuprofen type carprofen ketoprofen |
|
-sal
-sal- sal- |
anti-inflammatory
aspirin acetyl salicyclic acid. |
|
Cox 1 characteristics
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ER membrane bound
many tissues and blood blood clotting reg of vascular homeostasis renoprotection, gastroprotection coordination of hormones |
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Cox 2 characteristics
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induced by proinflammatory cytokines, growth factors, LP, pro and antiinflammatory mediators
Down regulated by steroids |
|
What are the major species differences of the PK parameters of NSAIDS
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Half life, and clearance
|
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Selective COX-1 inhibitors
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Aspirin
Ketoprofen Flunixin Phenylbutazone |
|
Selective COX-2 inhibitor
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Deracoxib
Firocoxib - highly selective Carprofen Meloxicam |
|
Aspirin
|
Selective COX 1 inhibitor
Irreversible effect on platelet aggreggation |
|
Ketoprofen
|
COX -1 inhibitor
Propionic acid derivative |
|
Piroxicam
|
COX - 1 inhibitor
Adjuctive therapy for transitional cell carcinoma of the urethra and bladder |
|
Phenylbutazone
|
COX -1 inhibitor
Enolic acid Most used in horse |
|
Deracoxib
|
COX - 2 inhibitor
|
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Firocoxib
|
Cox - 2 inhibitor
|
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Acetominophen
|
Not approved for use in animals
Not a COX inhibitor metabolism creates toxic intermediate in cats |
|
Carprofen
|
1st NSAID approved for dogs, anti-inflammatory, analgesic
Propionic acid derivative |
|
Diclofenac
|
acetic acid derivative
|
|
Etodolac
|
acetic acid derivative
|
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Flunixin
|
approved in cattle, no chronic use in dogs due to GI sensitivities
|
|
Flurbiprofen
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Not approved in animals
ophthalmic preparation pH balanced, non-irritating |
|
Ibuprofen
|
not approved in animals
|
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Meloxicam
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not approved in cats
|
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Naproxen
|
not approved in animals
|
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Piroxicam
|
used to treat transitional cell carcinoma, but not anitneoplastic, not used as anit-inflammatory
|
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Tepoxalin
|
works to decrease PGs and leukotrienes, COX and LOX blocker
|
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Bovine/Caprine/Ovine/Porcine NSAID
|
Flunixin
|
|
Equine NSAID
|
Phenylbutazone
Flunixin |
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Canine NSAID
|
Carprofen
Meloxicam |
|
Feline NSAID
|
no good choice
Meloxicam only once |
|
Avian/Exotic
|
Meloxicam
|
|
Whole animal response to NSAIDS
|
analgesic, antipyretic, antiinflammatory, antithrombotic, and antiendotoxemic
|
|
Inihibition of Cox 1 can cause
|
toxic effects such as elimination of gastro and renal protective mechanisms
|
|
Cox 1 is responsible for production of what inflammatory mediators
|
TxA2, PGE2, PGI2
|
|
Expression of Cox 2 is increased on exposure to
|
LPS, IL-1, TNFa, growth factors, bacterial toxins, mitogens, immune and inflammatory stimuli
|
|
Cox -2 is downregulated by
|
glucocorticoids at mRNA level
|
|
Highly selective Cox 2 inhibitors
|
Etoricoxib, firocoxib, lumiracoxib, robenacoxib
|
|
Which species has the longest NSAID half life?
|
Man
|
|
PG effect GI mucosa by ______ so NSAIDS _____
|
increasing mucous production
decrease mucous production |
|
Hepatotoxicity associated with NSAIDS is what type of adverse reaction?
|
Type 2, no known mechanism
|
|
Horses have lower toxicy reaction to NSAIDs because
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It is less protein bound, so lower serum concentration levels are necessary.
|
|
Dogs have higher renal toxicity occurance with NSAIDs compared to other species because
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Dogs have higher Cox 2 enzyme in kidney than other species
|
|
Flunixin is approved for use in _____ .
|
horses, cattle and swine
|
|
In horses flunixin is approved for the treatment of
|
inflammation andpain associated with musculoskeletal disorders and pain of colic
|
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In cattle, flunixin is approved for the treatment of
|
pyrexia of BRDand endotoxemia
|
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In swine, flunixin is approved for
|
pyrexia of SRD
|