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25 Cards in this Set
- Front
- Back
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Tyr to DOPA
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Tyr hydroxylase tetrahydrobiopterin
Rate limiting enzyme, feedback inhibition |
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DOPA to DA
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aromatic L-amino acid decarboxylase
pyridoxal phosphate |
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DA to NE
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DA Beta-hydroxylase
Ascorbate |
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NE to Epi
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phenylethanolamine-N-methyltransferase
s-adenosylmethionine In adrenal medulla |
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NE
Reuptake Metabolism |
NET (Blocked by cocaine)
MAO-A, COMT |
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DA fxn/Cx relevance/Pharm interventions
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Motor fxn/Parkinsonism/L-DOPA
Cognitive fxn/mood/Schiz/Anti-psychotics Attention/ADD/Methylphenidate Reward/euphoria/Drug abuse/None |
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NE fxn/Cx/Pharm
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Arousal/motivation/depression/antidepressants
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Epi Fxn
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Blood pressure regulation
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Amphetamine
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Releases non-vesicular DA
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Antipsychotics
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Block DA from binding D2 Rec
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Cocaine
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Blocks DA reuptake from synapse
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Pargyline
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Blocks MAO metabolism of DA to DOPAC
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Alpha-methyltyrosine
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Inh of DOPA synthesis
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FLA 63
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Inhibition of NE synthesis from DA
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Reserpine, Tetrabenazine
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Inh w/vesicular storage of NE
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Clonidine
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Stimulation of receptors
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Phenoxybenzamine, phentolamine
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Blocking of receptors
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Desipramine
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inh of reuptake of NE
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Tropolone
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Inh of COMT inactivation of NE
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Beta 1 Ad Rec
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Gs
Inc HR, Inc ionotropy Inc cAMP |
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Beta-2 ad rec
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Gs
Smooth mm relax cAMP up |
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Beta-3 ad rec
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Gs, cAMP up
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alpha-1 ad rec
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Gq, Gi
Behavioral Smooth mm contraxn Inc IP3, Inc DAG |
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alpha-2 ad rec
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Gi
resynaptic behavioral dec cAMP |
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Epi fxn
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Modulate CV fxn @ CNS and Periphery
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