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89 Cards in this Set

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prevalence of uncomplicated GER in infancy:
1st 3 mo
@4mo
10-12mo
50% in 1st 3mo
67% of 4mo

only 5% 10-12 mo
Etiology of GER in peds
1. transient relaxation of LES
2. inadeq adaptation to increased abdominal pressure (cry, cough, etc)
3. anatomic problem with GE junction (hiatial hernia)
When is a clinical diagnosis of GER acceptable in Peds (what criteria)?
<6mo
thriving
What differentiates GERD from GER in peds
GERD is or can be a/w
poor wt gain or weight loss
recurrent emesis in older children
apnea or ALTE
asthma/recurrent pna
chronic cough
esophagitis, anemia from blood loss
irritability
dysphagia, back arching, food refusal, abnormal neck posture
If there's blood in the spit up, is it GER?
No, it's GERD
what is sandifer syndrome and when do you see it?
abnormal neck posturing - the head turns one way and the hips/legs the other way & back arches
a/w feeding
a/w either GERD or HIATAL HERNIA
infancy to early childhood (18-36mo)
PE signs of GER
possible epigastric tenderness &/or foul breath
what are the characteristics of emesis in GER in infants
can be a few cc--> several oz.
NONbloody
NON bilious
effortless to mildly forceful
happy spitters
a/w feeds or a little while after
What are some symptoms of GER in older kids
Pain - chest or substernal or epigastric
Regurg
Night awakenings
bad taste in mough
food gets "stuck"
related to diet/meals
chronic cough
hoarseness
sore throat
what are some differentials for persistent vomiting in babies
anatomic obstruction
hydrocephalus
inborn metabolic errors
infection (UTI, sepsis, etc)
what are some differentials for GER/D
eosinophillic esophagitis
food allergies/intolerance
rumination
achalasia
cyclic vomiting
What disorders in kids are a/w GER
esophageal atresia & repair & other congenital anomalies of GI tract
hiatal hernia
neuroimpairment & delay
bronchopulm dysplasia
asthma
CF & any disease with chronic cough.
diagnostic studies for GER diagnosis (if not clinical dx)
1. pH probe study
2. EGD
3. scintigraphy & multiple intraluminal electrical imedance measures are not generally used in kids (lack of standardized measures)
pH probe study - what is it and benefits?
measures amount of acid in 24hrs - detects episodes of reflux and its association with symptoms
able to rule out anatomic cause
determines effectiveness of esophageal clearance & med effectiveness
what is the downside of pH probe
cannot detect NON acid reflux or GER complications a/w normal GER
not able to determine apnea
benefit of EGD for dx of GER
visualization and biopsy of esophageal epithelium - able to determine presence of other problems
reflux vs. non reflux
prob w/ EGD for dx of GER in kids
not standardized for kids
requires sedation
cannot tell the extent of GER
what TLC recommendations would you make for INFANT with GER
small frequent feeds and frequent burping
thicken formula - 1 tsp rice cereal/oz
position - left side, not in infant seat after eating
hypoallergenic formula - consider
on tight diapers/waistbands
no tobacco smoke
what TLC recommendations would you make for OLDER KIDS with GER
sleep on left
increase HOB
no lying supine after eating
no acidic foods - limit chocolate, caffeine, mints, high fat foods
smaller, more frequent meals
no tight clothing
no NSAIDS
med classes for GER
antacids
H2RA
PPI
prokinetics
when to use H2RA vs PPI
H2RA for kids <1yo, PPI OK >1yo
can use either, otherwise
PPI can be dissolved (comes as solution or open caps)
What are the H2RA's most used in kids
ranitidine (Zantac)
famotidine (Pepcid)
What is the dose of Zantac?
5-10mg/kg/day divided BID or TID
What are the PPIs used in peds
omeprazole (Prilosec)
lansoprazole (Prevacid)
How much omeprazole
0.6-1mg/kg/day
when to give PPI
30 min before meals.
what prokinetics are used in GER
erythromycin
reglan
when is surgery appropriate for GERD
FTT
esophagitis/strictures
apneic spells
what are the characteristics of complicated GERD
poor wt gain
excessive crying/irritabiltiy
feeding problems
respiratory issues: wheezing, stridor, recurrent pneumonia
criteria for defining functional constipation
2+ symptoms for 2+ mo
criteria/def of functional constipation
<3BM/week
>1 encopresis/wk
impaction
large stool
retentive posturing/withholding
pain with defecation
prevalence of functional constipation in kids
1-2% primary school kids
what should you suspect in a 3yo that is grunting, straining, reddening w/ bowel movements?
this is NORMAL in a 3mo - not a sign of constipation
what are the risk fc for functional constipation?
painful defecation
skeletal dysfunction / weakness
psych issues (control / authority)
modesty
meds
what is the onset of hirsprungs disease vs. constipation?

presence of abdominal distension?

normal nutrition & growth?
onset:
Hirshprungs: @ birth
Constipation: 2-3yo

abdominal distension is present in Hirshprungs, but not in constipation

nutrition and growth are poor in Hirshprungs, but normal in constipation
what are non pharm mgt options for constipation (dietary, behavior, and educational)
Diet: increase fluids, decrease milk, increase fiber

Behavior: scheduled toileting - sit on toilet x20min after meals, use foot leverage, diary, positive reinforcement

Education: Assurance that it's OK, describe importance of regularBM (explain dilation), importance of maintaining treatment regimen x3mo
what is used to relieve constipation if there is impaction
soap suds enema
what Rx measures can be used for constipation
barley malt extract: 1-2 tsp per feeding BID or TID (safe in small infants)

Miralax - daily, can increase to more often

Senna - for short periods it's OK
what are the criteria for functional abdominal pain
3+ occassions over 3 mo
persists >3mo
affects normal activity
there is no discernable organic cause
>5yo (consider organic cause if less than 5yo)
what family history is common in children with functional abdominal pain
IBS
ulcers
migraine HA
what is the common clinical presentation of functional abd pain
episodic abdominal pain (periumbilical, vague localization)
self-limited (30min-3hr)
Not a/w meals/activities
may start with N/V or autonomic arrousal
interferes w/ ADl
Generally no signs
what is the differential dx of functional abd pain
constipation
recurrent UTI
IBS
lactose intol or food allergy
PUD
lead poisoning
eosinophillic esophagitis
GER
IBD
Giardia
Abdominal Migraine
Uteropelvic junction obstruction
GYN conditions
muscular
abuse
In a child with recurrent abdominal pain with suspected functional etiology:

what tests would you do if you suspected IBD
ESR
serum protein
albumin
guiac
In a child with recurrent abdominal pain with suspected functional etiology:

what tests would you do if you suspected celiac (FTT)
tissue transglutinase
In a child with recurrent abdominal pain with suspected functional etiology:

what test should you always do?
LEAD
Pregnancy test in female
In a child with recurrent abdominal pain with suspected functional etiology:

what tests would you do if there was marked diarrhea, nonbloody, and you suspect pathogen
stool O&P
Giardia

probably also test for Celiac (tissue transflut) and IBD (ESR, serum protein, serum albumin, guiac)
In a child with recurrent abdominal pain with suspected functional etiology:

what tests would you do if you suspected lactose intol
trial a lactose free diet
In a child with recurrent abdominal pain with suspected functional etiology:

what tests would you do if you suspected constipation
abdominal x-ray
In a child with recurrent abdominal pain with suspected functional etiology:

what tests might you consider just in general?
CBC
macroscopic UA
Stool blood test
what is the management of functional abdominal pain?
assurance & behavioral approach - CBT is also helpful for getting through it and getting the plan down

peppermint oil

diary of foods / pain
high fiber sometimes?
decrease carbs?
decrease milk products?

shift attn to childs accomplishments and other parts of life.
In a child with recurrent abdominal pain with suspected functional etiology:
what are the RED FLAGS that it might be an organic cause
weight loss
nocturnal pain
recurrent emesis
abnormal PE findigns
abnormal lab values or +guiac
decreased albumin, increased ESR, anemia, increased amylase/lipase
what is the definition of celiac disease?
intestinal sensitivity to the glandin fractions of gluten in wheat/rye/barley/ and sometimes oats
when does celiac disease generally present and what's the prevalence in the US
1st 2yrs of life - about 6-12 mo after intro of gluten to the diet

1:300
what are some risk fc for celiac disease
Family hist
type 1 DM
IgA deficiency
Downs
what are the clinical signs of Celiac disease in a crisis
dehydration
can have shock and acidosis
what are other clinical signs and symptoms of celiac disease?
diarrhea: intermittent and becomes continuous, pale, bulky, frothy, greasy, foul smelling

constipation (from dehydration)
emesis
abdominal pain

FTT with onset of diarrhea and distended abdomen from gas

anemia, FTT, vitamin deficiencies in later stages
whatare the diagnostic criteria for celiac??

what is the definitive dx of celiac disease? what other tests can be done?
1. small bowel microscopic changes
2. clinical improvement on gluten free diet

***biopsy of small bowel***
3-day stool collection
impaired oral glucose tol test
tissue transgluinase (will be false pos in IgA defic)
what is the treatment for celiacs dis
gluten free for life

assure high enough calories and fat intake

in the acute phase: decrease milk and increase vitamins and supplements, test oats after recovery

corticosteroids only when very ill and profound anorexia --> will speed recovery
what hx questions/PE/dx tests are most important in a child with emesis or regurg
pain
consider BMP for electrolyte abnormalities
consider upper GI to r/o anatomic cause in young infants
think of increased ICP
what is achalasia?
failure of the LES to relax that is a/w abnormal nonperistaltic activity of the esophagus and vomitting/regurg
at what age does achalasia generally present
over 5yo
what is the clinical presentation of achalasia
retrosternal pain, sensation of food impaction
dysphagia relieved with forceful swallowing and drink a lot with meals

chronic cough/wheeze, may have recurrent aspiration
anemia
poor wt gain
how is achalasia diagnosed
on a barium esophagram: there is a "beak" shaped dilated esophagus at the GE junction
what is the treatment of achalasia
pneumatic dilation of LES
botulinum toxin
surgical - heller myotomy - divides the LES
what should be suspected if emesis is BILIOUS and what should eb done?
suspect intestinal obstruction
IMMEDIATE referral
clinical presentation of pyloric stenosis
vomitting, rapidly becomes projectile and after each feeding
emesis may be bloody
emesis is rarely bilious
hungry, ravenous
constipation
dehydration
wt loss, fretfullness

olive shaped mass at RUQ, especialy after vomiting
at what age is pyloric stenosis most common
2-4wk old
sometmes at birth
how is pyloric stenosis diagnosed
upper GI or US
what is the treatmetn for pyloric stenosis
pyloromyotomy

**treat dehydration and electrolyte imbalance before surgery**
what are the differntials for vomiting
GER/GERD
Eosinophilic Esophagitis
Achalasia
Food Allergies/Intol
Cyclic Vomiting
Rumination
UTI
Gastritis
Gastric outlet obstruction
CNS masses
otitis or sinusitis
metabolic disease that causes acidosis
psychogenic vomitting
what is the age of presentation of food allergies
generally childhood allergies present early, like at 1yo
what are the symptoms of food allergies?

what are the signs
vomitting, diarrhea, cough/congestion/breathing probs.

mild to fatal reactions

hives, angioedema, eczema, shock anaphylaxis, hypotension
diarrhea, often bloody (with milk)
what is the best diagnosis of food allergies
Oral challenges/elimination diet
RASTs and skin tests have high flase positives
define cyclic vomiting
recurrent episodes of intense vomiting, hrs to days
what's the cause of cyclic vomiting
unknown
what is the clin presentation of cyclic vomiting
intense vomiting interspersed with periods of being fine
may be abdominal pain
what's a risk fc for cyclic vomiting
family hx of migraines
how is cyclic vomiting diagnosed?
rule out other possibilities
what is the treatment for cyclic vomiting
prevent vomiting
rehydration
what is the prognosis for cyclic vomiting
migraines in adolescence
what is rumination
chronic regurg of partially digested foods

assumed psych basis
what is the clinical presentation of rumination
halitosis / bad taste
chronic regurg that is either expelled or reswallowed
generally seen in child who is institutionalized or understimulated.
how is rumination diagnosed
rule out other disorders and do a psych eval
treatment for rumination
behavioral therapy
what is eosinophilic esophagitis
eosinophilic infiltrate of esophageal mucosa r/t food allergy that leads to chronic inflammation
who/when do kids get eosinophilic esophagitis
peaks in childhood and adolescence

suspect in kids known to have food allergies
what is the clinical presentation of eosinophilic esophagitis?
abdominal pain
emesis or reflux
diarrhea
sensation of food getting stuck

may see weight loss and FTT
what is the diagnosis of eosinophilic esophagitis
no improvemnt with meds for regurg

EGD - will show classic signs

will improve with food avoidance
what is the treatment for eosinophilic esophagitis
avoidance diet
may need corticosteroids (inh or po)