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13 Cards in this Set
- Front
- Back
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Paint hat results from long-term changes in nociceptor sensitivity to stimuli
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inflammatory pain
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Irritation of the conducting fibers of nociceptors
(from peripheral nerves, not from nerve endings) |
Neuropathic pain
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Involving altered activity of CNS neurons, mainly anterolateral system
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Central pain
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When nociceptors become more responsive to stimuli after they respond to a noxious stimulus.
Threshold is lowered |
Sensitization
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Increase in pain sensation produced at a given intensity
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Hyperalgesia
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Decrease in activation threshold so otherwise innocuous stimuli are perceived as painful
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Allodynia
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What are some of the toxic soup of chemicals that cause sensitization
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Bradykinin, histamine, PG, serotonin, K, neuropeptides, neurotrophic factors
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Glu released from nociceptors has 2 classes of amino acid channels
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AMPA & NMDA
NMDA blocked by Mg, but with activation/depol, Mg falls off and opens channel |
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phenomenon caused by convergency of somatic and visceral nociceptive inputs to dorsal horn spinotahalmic tract neurons. Stimulus detection and conduction are normal, but localization is faculty bc of how the central pathway is organized.
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Referred pain
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When pain is of neural, rather than sensory orgin
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Radicular pain
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When trigger for pain is not from nerve endings
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Ectopic
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Phantom limb pain is a form of
arises from confused neurons in anterolateral system |
central pain
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What are 2 primary causes of phantom limb pain?
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1. Disinhibition: inhibitory interneurons are lost-->inc. in a ctivity of anterolateral system
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