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14 Cards in this Set

  • Front
  • Back
Info for nociception, temperature, and nondiscriminative touch is carried to the brain by
anterolateral system
Reception in CNS of signals evoked by strong/tissue damaging stimuli
Nociception
Unpleasant sensation from specific origin on body
Pain
two types of nocicpetors
A-gamma & C
Type of nociceptors that respond to high intensity mechanical, chemical, and thermal stimulation

Has slow aching pain
C
How do noxious stimuli activate nociceptors?
TRPVRI heat sensing ion channels
What are the routes of the anterolateral tract
1. Spinothalamic: non-stop, direct, fast pain

2. Indirect, slow aching pain:
a. Paleospinothalamic
b. Spinoreticular tract
c. Spinomesencephalic tract
Tract that makes connections in the brainstem reticular formation to thalamus
Paleospinothalamic
Tract that projects to the medullary and pontine reticular formations to thalamus
Spinoreticular
Tract from periaqueductal gray neurons to amydala or back to SC
Spinomesencephalic
Widening of central canal in cervial region due to malfxn in production of CSF

SC cavitation

Produces bilateral losses of pain and temp
Syringomyelia
Infarct of ant. spinal a
Loss anterolateral system of pain & temp

Dorsal columns fnxal so MVP is too
Suppression of nociceptive signals
Analgesia
Enkephalins
regulate nociceptive transmission and contribute to analgesia by:

dec. cal entry into nociceptor and dec. EPSP PRESYNAPTIC transmission

Activate K influx, hyperpolarizes: IPSP...this is POSTSYNAPTIC transmission