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14 Cards in this Set
- Front
- Back
Info for nociception, temperature, and nondiscriminative touch is carried to the brain by
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anterolateral system
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Reception in CNS of signals evoked by strong/tissue damaging stimuli
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Nociception
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Unpleasant sensation from specific origin on body
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Pain
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two types of nocicpetors
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A-gamma & C
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Type of nociceptors that respond to high intensity mechanical, chemical, and thermal stimulation
Has slow aching pain |
C
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How do noxious stimuli activate nociceptors?
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TRPVRI heat sensing ion channels
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What are the routes of the anterolateral tract
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1. Spinothalamic: non-stop, direct, fast pain
2. Indirect, slow aching pain: a. Paleospinothalamic b. Spinoreticular tract c. Spinomesencephalic tract |
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Tract that makes connections in the brainstem reticular formation to thalamus
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Paleospinothalamic
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Tract that projects to the medullary and pontine reticular formations to thalamus
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Spinoreticular
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Tract from periaqueductal gray neurons to amydala or back to SC
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Spinomesencephalic
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Widening of central canal in cervial region due to malfxn in production of CSF
SC cavitation Produces bilateral losses of pain and temp |
Syringomyelia
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Infarct of ant. spinal a
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Loss anterolateral system of pain & temp
Dorsal columns fnxal so MVP is too |
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Suppression of nociceptive signals
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Analgesia
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Enkephalins
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regulate nociceptive transmission and contribute to analgesia by:
dec. cal entry into nociceptor and dec. EPSP PRESYNAPTIC transmission Activate K influx, hyperpolarizes: IPSP...this is POSTSYNAPTIC transmission |