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28 Cards in this Set
- Front
- Back
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What is the receptor on a b-cell called?
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B-cell receptor (BCR)
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What does the clonal selection model state?
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That an antigen picks a B-cell receptor and then binds to only one type-b cell and then this B cell replicates
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What is the group of identical cells called after an antigen selects and binds to it?
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clone
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B cells become what type of cell?
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Plasma cells and memory cells
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Each B cell has a specific what?
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B-cell receptor, each with its own unique 3-D shape
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Only what type of cell undergoes clonal expansion?
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Only the B cell with a BCR that has a shape that fits the antigen undergoes clonal expansion.
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What is another term for clonal expansion?
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increased mitotic division
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What happens during clonal expansion to B cells?
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cytokines secreted by helper T cells stimulate B cells to clone
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What do plasma cells produce?
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Y-shaped proteins antibodies: custom made to acquired specific immunity/IG
and B-memory cells |
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Most of the cloned cells become what type of cells?
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plasma cells
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Antibodies identical to the B-cell Receptor of the B cell that was activated are secreted from what cell?
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plasma cell
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How is long-term immunity possible?
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some cloned B cells (initiated by cytokines from T cells) become memory B cells, if the same antigen enters the system again, memory B cells quickly divide and give ise to more plasma cells capable of quickly producing the correct type antibody
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Why are plasma cells larger than regular B cells?
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Because they have extensive rough ER for the mass production and secreiton of antibodies to a specific antigen
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What type of antibodies are secreted by the plasma cells?
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Antibodies IDENTICAL to the BCR of the B cell that was activated are secreted from the plasma cell.
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What happens once the threat of an infection has passed?
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The development of new plasma cells ceases, and those present undergo apoptosis, cell suicide
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What is the process of programmed cell death?
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Apoptosis
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Defense by B cells is called what?
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Antibody-mediated immunity or humoral immunity
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Where are the antibodies of plasma cells made?
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In the rough ER
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What do plasma cells produce?
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Y-shaped proteins antibodies: custom made to acquired specific immunity/IG
and B-memory cells |
|
|
Most of the cloned cells become what type of cells?
|
plasma cells
|
|
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Antibodies identical to the B-cell Receptor of the B cell that was activated are secreted from what cell?
|
plasma cell
|
|
|
How is long-term immunity possible?
|
some cloned B cells (initiated by cytokines from T cells) become memory B cells, if the same antigen enters the system again, memory B cells quickly divide and give ise to more plasma cells capable of quickly producing the correct type antibody
|
|
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Why are plasma cells larger than regular B cells?
|
Because they have extensive rough ER for the mass production and secreiton of antibodies to a specific antigen
|
|
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What type of antibodies are secreted by the plasma cells?
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Antibodies IDENTICAL to the BCR of the B cell that was activated are secreted from the plasma cell.
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What happens once the threat of an infection has passed?
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The development of new plasma cells ceases, and those present undergo apoptosis, cell suicide
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|
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What is the process of programmed cell death?
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Apoptosis
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Defense by B cells is called what?
|
Antibody-mediated immunity or humoral immunity
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|
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Where are the antibodies of plasma cells made?
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In the rough ER
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