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6 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Epinephrine (MOA & PK)
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MOA - Activation of sympathetic nervous system and all concomitant effects
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PK - IV; very short half-life (minutes); degraded rapidly by COMT and MAO; Catechol moiety prevents ready absorption and CNS penetration
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Epinephrine (CU & T)
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CU - Glaucoma (increase outflow); anaphylaxis; hypotension; heart failure; reduced local blood flow; severe asthma
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T - Arrhythmias, hypertension, cerebral hemorrhage, tachycardia, anxiety
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Norepinephrine (MOA & PK)
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MOA - Activation of sympathetic nervous system and all concomitant effects but more specific effect on a1 and B1
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PK - IV; very short half-life (minutes); degraded rapidly by COMT and MAO; Catechol moiety prevents ready absorption and CNS penetration; a1=a2; B1>>B2
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Norepinephrine (CU & T)
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CU - Hypotension; heart failure
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T - Arrhythmias, hypertension, cerebral hemorrhage, tachycardia, anxiety, reflex bradycardia increased risk of cardiac ischemia
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Dopamine (MOA & PK)
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MOA - low dose: potent dopamine receptor agonist, dilation of renal and coronary vascular beds; medium doses: speeds heart rate (beta); high doses: produces vasoconstriction (alpha); also causes release of catecholamines
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PK - IV; very short half-life (minutes); degraded rapidly by COMT and MAO; Catechol moiety prevents ready absorption and CNS penetration; D1=D2 >>B>>a
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Dopamine (CU & T)
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CU - Hypotension; heart failure especially useful for cardiogenic and hypovolemic shock which are associated with low cardiac output and compromised renal function
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T - Arrhythmias, hypertension, cerebral hemorrhage, tachycardia, anxiety, reflex bradycardia increased risk of cardiac ischemia
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