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30 Cards in this Set
- Front
- Back
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Granulocytic Bone Marrow Storage Pool
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storage of maturing cells allows for rapid response to the demand for increased white blood cells, with a two to three fold increase in circulating leukocytes possible in just 4-6 hrs.
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storage pool
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can increase circ numbers in 4-6 hrs. Stored in marrow
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circulating pool
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not in bone marrow
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Neutrophils-circulating
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counted on CBC
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Neutrophils Marginated
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not counted in CBC
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CD11 CD18
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mediates adhesion of neutrophils
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Neutrophil Process
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rolling, tight adhesion
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Leukocytosis
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absolute increase in the number of leukocytes. Counts greater than 10,000/11,000. Majority of cases due to increase in neutrophils
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Mechanisms of Leukocytosis
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infection, inflammation, stress, overexertion, seizures, anxiety, anesthesia
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Leukomoik Reaction
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excessive WBC response (50,000) assoc with a cause outside the marow. May be neutrophilic
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Corticosteroids
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decrease emigration of neutrophils from blood into the tissues. Increase release of mature neut
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Neutrophilia
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absolute neutrophil count greater than 8000
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Mechanism of Neutrophilia
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incr prod by marow: infection, inflamm, hemolysis/ chronic blood loss, exogenously administered growth factor
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Leukocyte Adhesion Deficiency
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partial or total deficiency of CD11/18. Number of circulating neutrophils is increased. Assoc with severe and fatal bacterial infections.
**delayed detachmnet or prolonged healing of umbilical stump. |
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Lymphocytosis
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lymphocytes normally represent 20-40% of circulating WBC.
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Relative lymphocytosis
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neutrophilic leukocytosis
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Absolute Lymphocytosis
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more than 9000 in infants
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Physiologic Lymphocytosis
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rapid growth and development
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Benign Reactive Lymphocytosis
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pertusis, acute lymphocytosis
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Eosinophilia
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make up less than 5% of circulating leukocytes. Storage pool in marrow is 5x the sirculating population
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Etiology of Eosinophilia
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Allergic events, parasitic infections, dermatologic conditions
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Neutropenia
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decrease in the absolute neutrophil count, below accepted norms for age gender and race
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Risk of infection (by the numbers)
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100-1500
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Neutropenia Causes
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marrow reserve?
Primary hematologic disorder? |
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Pseudoneutropenia
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Low normal neutrophil count. No Hx of infxn. Most due to incr margination
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Infection induced neutropenia
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common during virla infxns, usu transient. Proctated neutropenia can be seen with mono
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drig induced neutropenia
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immune mediated or direct destruction
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Immune neutropenia
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antibodies against neutrophls or their precursors
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Congenital Neutropenia
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cyclic neutropenia
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Lymphopenia
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ALC <1000 in adults or 15000 in children. Decr production, SCIDS, AIDS, aplastic anemia
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